A review of currently identified small molecule modulators of microRNA function von Van Meter, Emile N., Onyango, Jackline A., Teske, Kelly A.

Volltext

Methyllysine binding domains: Structural insight and small molecule probe development von Teske, Kelly A., Hadden, M. Kyle

Volltext

Interrogating direct NLRP3 engagement and functional inflammasome inhibition using cellular assays von Teske, Kelly A., Corona, Cesear, Wilkinson, Jennifer, Mamott, Daniel, Good, David A., Zambrano, Delia, Lazar, Dan F., Cali, James J., Robers, Matthew B., O’Brien, Martha A.

Volltext

Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues von Wen, Jiachen, Teske, Kelly A., Kyle Hadden, M.

Volltext

Novel VDR antagonists based on the GW0742 scaffold von Teske, Kelly A., Bogart, Jonathan W., Arnold, Leggy A.

Volltext

DELs enable the development of BRET probes for target engagement studies in cells von Teske, Kelly A., Su, Wenji, Corona, Cesear R., Wen, Jing, Deng, Jason, Ping, Yan, Zhang, Zaihong, Zhang, Qi, Wilkinson, Jennifer, Beck, Michael T., Nealey, Kendra R., Vasta, James D., Cong, Mei, Meisenheimer, Poncho L., Kuai, Letian, Robers, Matthew B.

Volltext

Biological evaluation and synthesis of calcitroic acid von Yu, Olivia B., Webb, Daniel A., Di Milo, Elliot S., Mutchie, Tania R., Teske, Kelly A., Chen, Taosheng, Lin, Wenwei, Peluso-Iltis, Carole, Rochel, Natacha, Helmstädter, Moritz, Merk, Daniel, Arnold, Leggy A.

Volltext

Probing the Ligand-Binding Pocket of BTN3A1 von Poe, Michael M, Agabiti, Sherry S, Liu, Caroline, Li, Victoria, Teske, Kelly A, Hsiao, Chia-Hung Christine, Wiemer, Andrew J

Volltext

Hydrogen peroxide activated quinone methide precursors with enhanced DNA cross-linking capability and cytotoxicity towards cancer cells von Wang, Yibin, Fan, Heli, Balakrishnan, Kumudha, Lin, Zechao, Cao, Sheng, Chen, Wenbing, Fan, Yukai, Guthrie, Quibria A., Sun, Huabing, Teske, Kelly A., Gandhi, Varsha, Arnold, Leggy A., Peng, Xiaohua

Volltext

Structure–Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors von Pace, Jennifer R, Teske, Kelly A, Chau, Lianne Q, Dash, Radha Charan, Zaino, Angela M, Wechsler-Reya, Robert J, Hadden, M. Kyle

Volltext

Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors von Teske, Kelly A., Dash, Radha Charan, Morel, Shana R., Chau, Lianne Q., Wechsler-Reya, Robert J., Hadden, M. Kyle

Volltext

Synthesis and Characterization of a Novel γ‑Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficac... von Poe, Michael M, Methuku, Kashi Reddy, Li, Guanguan, Verma, Ashwini R, Teske, Kelly A, Stafford, Douglas C, Arnold, Leggy A, Cramer, Jeffrey W, Jones, Timothy M, Cerne, Rok, Krambis, Michael J, Witkin, Jeffrey M, Jambrina, Enrique, Rehman, Sabah, Ernst, Margot, Cook, James M, Schkeryantz, Jeffrey M

Volltext

Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites von Teske, Kelly A., Bogart, Jonathon W., Sanchez, Luis M., Yu, Olivia B., Preston, Joshua V., Cook, James M., Silvaggi, Nicholas R., Bikle, Daniel D., Arnold, Leggy A.

Volltext

Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold von Teske, Kelly A, Rai, Ganesha, Nandhikonda, Premchendar, Sidhu, Preetpal S, Feleke, Belaynesh, Simeonov, Anton, Yasgar, Adam, Jadhav, Ajit, Maloney, David J, Arnold, Leggy A

Volltext

Anticancer activity of VDR-coregulator inhibitor PS121912 von Sidhu, Preetpal S., Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y., Guthrie, Margaret L., Fernstrum, Grant B., Vyas, Nishita D., Han, Lanlan, Preston, Joshua, Bogart, Jonathan W., Silvaggi, Nicholas R., Cook, James M., Singh, Rakesh K., Bikle, Daniel D., Arnold, Leggy A.

Volltext

Antitumor Activity of 3-Indolylmethanamines 31B and PS121912 von Guthrie, Margaret L, Sidhu, Preetpal S, Hill, Emily K, Horan, Timothy C, Nandhikonda, Premchendar, Teske, Kelly A, Yuan, Nina Y, Sidorko, Marina, Rodali, Revathi, Cook, James M, Han, Lanlan, Silvaggi, Nicholas R, Bikle, Daniel D, Moore, Richard G, Singh, Rakesh K, Arnold, Leggy A

Volltext

Complementary target engagement and functional assays to probe NLRP3 inflammasome pathway antagonism von O’Brien, Martha A., Robers, Matt, Teske, Kelly, Corona, Cesear, Vasta, Jim, Wilkinson, Jennifer, Lam, Ngan, Hoffman, Kaitlin Dunn, Cali, James, Lazar, Dan

Volltext

Biological evaluation and synthesis of calcitroic acid von Yu, Olivia B, Webb, Daniel A, Di Milo, Elliot S, Mutchie, Tania R, Teske, Kelly A, Chen, Taosheng, Lin, Wenwei, Peluso-Iltis, Carole, Rochel, Natacha, Helmstädter, Moritz, Merk, Daniel, Arnold, Leggy A

Volltext

Abstract 5389: Discovery of small molecule inhibitors of the interaction between PPARγ and SMRT von Min, Jaeki, Attia, Ramy Naguib, Arnold, Leggy A, Teske, Kelly, Connelly, Michele, Lemieux, George, Ashrafi, Kaveh, Shelat, Anang, Guy, R. Kiplin

Volltext

Peroxisome Proliferation-Activated Receptor δ Agonist GW0742 Interacts Weakly with Multiple Nuclear Receptors, Including the Vitamin D Receptor von Nandhikonda, Premchendar, Yasgar, Adam, Baranowski, Athena M, Sidhu, Preetpal S, McCallum, Megan M, Pawlak, Alan J, Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y, Kevin, Chinedum, Bikle, Daniel D, Ayers, Steven D, Webb, Paul, Rai, Ganesha, Simeonov, Anton, Jadhav, Ajit, Maloney, David, Arnold, Leggy A

Volltext