Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death von Cappuccio, Irene, Calderone, Agata, Busceti, Carla L, Biagioni, Francesca, Pontarelli, Fabrizio, Bruno, Valeria, Storto, Marianna, Terstappen, Georg T, Gaviraghi, Giovanni, Fornai, Francesco, Battaglia, Giuseppe, Melchiorri, Daniela, Zukin, Suzanne, Nicoletti, Ferdinando, Caricasole, Andrea

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Challenges in developing Geroscience trials von Rolland, Yves, Sierra, Felipe, Ferrucci, Luigi, Barzilai, Nir, De Cabo, Rafael, Mannick, Joan, Oliva, Anthony, Evans, William, Angioni, Davide, De Souto Barreto, Philipe, Raffin, Jeremy, Vellas, Bruno, Kirkland, James L.

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Strategies for delivering therapeutics across the blood–brain barrier von Terstappen, Georg C., Meyer, Axel H., Bell, Robert D., Zhang, Wandong

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Differentiation of Human Induced Pluripotent Stem Cells (hiPSC) into Endothelial-Type Cells and Establishment of an In Vitro Blood-Brain Barrier Model von Li, Yuan, Terstappen, Georg C., Zhang, Wandong

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Prediction of brain:blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems von Liu, Houfu, Dong, Kelly, Zhang, Wandong, Summerfield, Scott G., Terstappen, Georg C.

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A call for better understanding of target engagement in Tau antibody development von Bespalov, Anton, Courade, Jean-Philippe, Khiroug, Leonard, Terstappen, Georg C., Wang, Yipeng

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Combining experimental strategies for successful target deconvolution von Wilkinson, Isabel V.L., Terstappen, Georg C., Russell, Angela J.

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Target deconvolution strategies in drug discovery von Terstappen, Georg C, Schlüpen, Christina, Raggiaschi, Roberto, Gaviraghi, Giovanni

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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development von Loryan, Irena, Reichel, Andreas, Feng, Bo, Bundgaard, Christoffer, Shaffer, Christopher, Kalvass, Cory, Bednarczyk, Dallas, Morrison, Denise, Lesuisse, Dominique, Hoppe, Edmund, Terstappen, Georg C., Fischer, Holger, Di, Li, Colclough, Nicola, Summerfield, Scott, Buckley, Stephen T., Maurer, Tristan S., Fridén, Markus

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Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease von Rosi, Maria Cristina, Luccarini, Ilaria, Grossi, Cristina, Fiorentini, Anna, Spillantini, Maria Grazia, Prisco, Antonella, Scali, Carla, Gianfriddo, Marco, Caricasole, Andrea, Terstappen, Georg C, Casamenti, Fiorella

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Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain von Caricasole, Andrea, Copani, Agata, Caraci, Filippo, Aronica, Eleonora, Rozemuller, Annemieke J, Caruso, Alessandra, Storto, Marianna, Gaviraghi, Giovanni, Terstappen, Georg C, Nicoletti, Ferdinando

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In silico research in drug discovery von Terstappen, G C, Reggiani, A

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Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study von Volpato, Viola, Smith, James, Sandor, Cynthia, Ried, Janina S., Baud, Anna, Handel, Adam, Newey, Sarah E., Wessely, Frank, Attar, Moustafa, Whiteley, Emma, Chintawar, Satyan, Verheyen, An, Barta, Thomas, Lako, Majlinda, Armstrong, Lyle, Muschet, Caroline, Artati, Anna, Cusulin, Carlo, Christensen, Klaus, Patsch, Christoph, Sharma, Eshita, Nicod, Jerome, Brownjohn, Philip, Stubbs, Victoria, Heywood, Wendy E., Gissen, Paul, De Filippis, Roberta, Janssen, Katharina, Reinhardt, Peter, Adamski, Jerzy, Royaux, Ines, Peeters, Pieter J., Terstappen, Georg C., Graf, Martin, Livesey, Frederick J., Akerman, Colin J., Mills, Kevin, Bowden, Rory, Nicholson, George, Webber, Caleb, Cader, M. Zameel, Lakics, Viktor

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Label-free detection of small-molecule binding to a GPCR in the membrane environment von Heym, Roland G., Hornberger, Wilfried B., Lakics, Viktor, Terstappen, Georg C.

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Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity von Galvagni, Federico, Pennacchini, Susanna, Salameh, Ahmad, Rocchigiani, Marina, Neri, Francesco, Orlandini, Maurizio, Petraglia, Felice, Gotta, Stefano, Sardone, Gian Luca, Matteucci, Giacomo, Terstappen, Georg C, Oliviero, Salvatore

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Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs von Li, Yuan, Sun, Xueying, Liu, Houfu, Huang, Liang, Meng, Guofeng, Ding, Yu, Su, Wenji, Lu, Jiaqi, Gong, Sophie, Terstappen, Georg C., Zhang, Ru, Zhang, Wandong

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Drug Distribution into Peripheral Nerve von Liu, Houfu, Chen, Yan, Huang, Liang, Sun, Xueying, Fu, Tingting, Wu, Shengqian, Zhu, Xiaoyan, Zhen, Wei, Liu, Jihong, Lu, Gang, Cai, Wei, Yang, Ting, Zhang, Wandong, Yu, Xiaohong, Wan, Zehong, Wang, Jianfei, Summerfield, Scott G., Dong, Kelly, Terstappen, Georg C.

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Brain delivery research in public-private partnerships: The IMI-JU COMPACT consortium as an example von Meyer, Axel H., Untucht, Christopher, Terstappen, Georg C.

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Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease Modeling von Janssen, Katharina, Bahnassawy, Lamiaa, Kiefer, Claudia, Korffmann, Jürgen, Terstappen, Georg C., Lakics, Viktor, Cik, Miroslav, Reinhardt, Peter

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Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1 von Scali, Carla, Caraci, Filippo, Gianfriddo, Marco, Diodato, Enrica, Roncarati, Renza, Pollio, Giuseppe, Gaviraghi, Giovanni, Copani, Agata, Nicoletti, Ferdinando, Terstappen, Georg C., Caricasole, Andrea

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