CAR T-cell therapy in multiple myeloma: more room for improvement von Teoh, Phaik Ju, Chng, Wee Joo

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ADARs, RNA editing and more in hematological malignancies von Teoh, Phaik Ju, Koh, Mun Yee, Chng, Wee Joo

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IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification von Teoh, Phaik Ju, Chung, Tae-Hoon, Chng, Pamela Y. Z., Toh, Sabrina H. M., Chng, Wee Joo

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p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain) von Teoh, Phaik Ju, An, Omer, Chung, Tae-Hoon, Vaiyapuri, Thamil, Raju, Anandhkumar, Hoppe, Michal M., Toh, Sabrina H. M., Wang, Wilson, Chan, Ming Chun, Fullwood, Melissa J., Jeyasekharan, Anand D., Tergaonkar, Vinay, Chen, Leilei, Yang, Henry, Chng, Wee Joo

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PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation von Teoh, Phaik Ju, Bi, Chonglei, Sintosebastian, Chirackal, Tay, Liang Seah, Fonseca, Rafael, Chng, Wee Joo

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Resistance to immunomodulatory drugs in multiple myeloma: the cereblon pathway and beyond von Teoh, Phaik Ju, Koh, Mun Yee, Mitsiades, Constantine, Gooding, Sarah, Chng, Wee Joo

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Elucidating the Role of ADAR1 in Regulating Immunotherapeutic Response in Multiple Myeloma von Koh, Mun Yee, Teoh, Phaik Ju, Chung, Tae-Hoon, Chen, Leilei, Chng, Wee Joo

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Integrated Molecular Landscape of Lesions in Cereblon and Its Pathway in Myeloma Patients: Insights into Mechanisms of Relapse from IMiD-Based Treatments von Leypoldt, Lisa B, Steinbrunn, Torsten, Teoh, Phaik Ju, De Matos Simoes, Ricardo, Shirasaki, Ryosuke, Mitsiades, Constantine S

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Functional Characterization of Genes Residing in Chromosomal Regions with “High-Risk” Lesions in Multiple Myeloma von Teoh, Phaik Ju, De Matos Simoes, Ricardo, Chung, Tae-Hoon, Steinbrunn, Torsten, Leypoldt, Lisa B, Dashevsky, Olga, Vazquez, Francisca, Chng, Wee-Joo, Mitsiades, Constantine S

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P-351 Are genomic lesions of cereblon pathway genes sufficient to explain clinical relapses from IMiD-based treatment in multiple myeloma (MM)? von Leypoldt, Lisa, Steinbrunn, Torsten, Teoh, Phaik Ju, Simoes, Ricardo de Matos, Shirasaki, Ryosuke, Mitsiades, Constantine

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Systematic Functional Characterization for Loss of Function Events Cooperating with TP53 Loss in High-Risk 17p13(del) Multiple Myeloma von Teoh, Phaik Ju, De Matos Simoes, Ricardo, Chung, Tae-Hoon, Lee, Mick, Dashevsky, Olga, Yamano, Shizuka, Foo, Roger, Chng, Wee Joo, Mitsiades, Constantine S.

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Aberrant hyperediting of the myeloma transcriptome by ADAR1 confers oncogenicity and is a marker of poor prognosis von Teoh, Phaik Ju, An, Omer, Chung, Tae-Hoon, Chooi, Jing Yuan, Toh, Sabrina H.M., Fan, Shuangyi, Wang, Wilson, Koh, Bryan T.H., Fullwood, Melissa J., Ooi, Melissa G., de Mel, Sanjay, Soekojo, Cinnie Y., Chen, Leilei, Ng, Siok Bian, Yang, Henry, Chng, Wee Joo

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OA-24 A Novel Mouse Model Engineered With Human Immune System Is a Translationally-Important Model for Studies Related to Immune-Microenvironment and Immunotherapies in Multiple My... von Teoh, Phaik Ju, Tan, Joel, Tan, Tze King, Chung, Tae-Hoon, Koh, Mun Yee, Chen, Qingfeng, Chng, Wee Joo

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Targeting Mutant KRAS with Novel Mutant-Specific Pharmacological Inhibitors: Activity Against Myeloma and Other Lymphoid Malignant Cells and Molecular Mechanisms of Resistance von Steinbrunn, Torsten, Shirasaki, Ryosuke, Dashevsky, Olga, Tang, Huihui, Yamano, Shizuka, Mizuno, Rin, Sugihara, Takeru, Teoh, Phaik Ju, Leypoldt, Lisa B, Kaji, Mariko, Sorrell, Jeffrey, Glassner, Brian J, De Matos Simoes, Ricardo, Christensen, James, Mitsiades, Constantine S

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Potential IL6R-ADAR1-STAT3 Interplay Promotes Oncogenicity in 1q21(amp) Multiple Myeloma von Teoh, Phaik Ju, Chung, Tae-Hoon, Chen, Leilei, Chng, Wee Joo

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P-248 CRISPR-Based Functional Genomics Studies Identify Mechanisms of Multiple Myeloma (MM) Cell Response to vs. Resistance Against Novel Pharmacological Mutant-Specific KRAS Inhib... von Steinbrunn, Torsten, Shirasaki, Ryosuke, Dashevsky, Olga, Tang, Huihui, Yamano, Shizuka, Teoh, Phaik Ju, Leypoldt, Lisa, Mizuno, Rin, Glassner, Brian, de Matos Simoes, Ricardo, Christensen, James, Mitsiades, Constantine

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Abstract 5457: The relationship between ADAR1 and STAT3 and its relevance in multiple myeloma von Teoh, Phaik Ju, Chung, Tae Hoon, Yang, Henry, Chen, Polly, Chng, Wee Joo

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Histone methyltransferase NSD2 activates PKCα to drive metabolic reprogramming and lenalidomide resistance in multiple myeloma von Chong, Phyllis S Y, Chooi, Jing-Yuan, Lim, Julia S L, Leow, Aaron C Y, Toh, Sabrina Hui Min, Azaman, Irfan, Koh, Mun Yee, Teoh, Phaik Ju, Tan, Tuan Zea, Chung, Tae-Hoon, Chng, Wee Joo

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JMJD3 Is a Potential Tumor Suppressor Gene That Cooperates with TP53 in Chromosome 17p13 von Teoh, Phaik Ju, Chung, Tae-Hoon, Sintosebastian, Chirackal, Fonseca, Rafael, Chng, Wee Joo

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P-067: Systematic functional characterization for loss of function events cooperating with TP53 loss in high-risk 17p13(del) multiple myeloma von Teoh, Phaik Ju, De Matos Simoes, Ricardo, Chung, Tae-Hoon, Lee, Mick, Foo, Roger, Chng, Wee Joo, Mitsiades, Constantine

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