Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours von Fernandes Neto, João M., Nadal, Ernest, Bosdriesz, Evert, Ooft, Salo N., Farre, Lourdes, McLean, Chelsea, Klarenbeek, Sjoerd, Jurgens, Anouk, Hagen, Hannes, Wang, Liqin, Felip, Enriqueta, Martinez-Marti, Alex, Vidal, August, Voest, Emile, Wessels, Lodewyk F. A., van Tellingen, Olaf, Villanueva, Alberto, Bernards, René

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Expression and Cellular Distribution of P-Glycoprotein and Breast Cancer Resistance Protein in Amyotrophic Lateral Sclerosis Patients von van Vliet, Erwin A, Iyer, Anand M, Mesarosova, Lucia, Çolakoglu, Hilal, Anink, Jasper J, van Tellingen, Olaf, Maragakis, Nicholas J, Shefner, Jeremy, Bunt, Ton, Aronica, Eleonora

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Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression von de Vries, Nienke A., Hulsman, Danielle, Akhtar, Waseem, de Jong, Johann, Miles, Denise C., Blom, Marleen, van Tellingen, Olaf, Jonkers, Jos, van Lohuizen, Maarten

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Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism von van Herwaarden, Antonius E, Wagenaar, Els, van der Kruijssen, Cornelia M M, van Waterschoot, Robert A B, Smit, Johan W, Song, Ji-Ying, van der Valk, Martin A, van Tellingen, Olaf, van der Hoorn, José W A, Rosing, Hilde, Beijnen, Jos H, Schinkel, Alfred H

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Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its M... von VLAMING, Maria L. H, ESCH, Anita Van, DE STEEG, Evita Van, PALA, Zeliha, WAGENAAR, Els, TELLINGEN, Olaf Van, SCHINKEL, Alfred H

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Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin von Pang, Baoxu, Qiao, Xiaohang, Janssen, Lennert, Velds, Arno, Groothuis, Tom, Kerkhoven, Ron, Nieuwland, Marja, Ovaa, Huib, Rottenberg, Sven, van Tellingen, Olaf, Janssen, Jeroen, Huijgens, Peter, Zwart, Wilbert, Neefjes, Jacques

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Uncoupling DNA damage from chromatin damage to detoxify doxorubicin von Qiao, Xiaohang, van der Zanden, Sabina Y., Wander, Dennis P. A., Borràs, Daniel M., Song, Ji-Ying, Li, Xiaoyang, van Duikeren, Suzanne, van Gils, Noortje, Rutten, Arjo, van Herwaarden, Tessa, van Tellingen, Olaf, Giacomelli, Elisa, Bellin, Milena, Orlova, Valeria, Tertoolen, Leon G. J., Gerhardt, Sophie, Akkermans, Jimmy J., Bakker, Jeroen M., Zuur, Charlotte L., Pang, Baoxu, Smits, Anke M., Mummery, Christine L., Smith, Linda, Arens, Ramon, Li, Junmin, Overkleeft, Hermen S., Neefjes, Jacques

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Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2 von de Gooijer, Mark C., de Vries, Nienke A., Buckle, Tessa, Buil, Levi C.M., Beijnen, Jos H., Boogerd, Willem, van Tellingen, Olaf

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SLC1A3 contributes to L‐asparaginase resistance in solid tumors von Sun, Jianhui, Nagel, Remco, Zaal, Esther A, Ugalde, Alejandro Piñeiro, Han, Ruiqi, Proost, Natalie, Song, Ji‐Ying, Pataskar, Abhijeet, Burylo, Artur, Fu, Haigen, Poelarends, Gerrit J, van de Ven, Marieke, van Tellingen, Olaf, Berkers, Celia R, Agami, Reuven

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Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101) von Gaillard, Pieter J, Appeldoorn, Chantal C M, Dorland, Rick, van Kregten, Joan, Manca, Francesca, Vugts, Danielle J, Windhorst, Bert, van Dongen, Guus A M S, de Vries, Helga E, Maussang, David, van Tellingen, Olaf

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The impact of P‐glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors von de Gooijer, Mark C., Zhang, Ping, Weijer, Ruud, Buil, Levi C.M., Beijnen, Jos H., van Tellingen, Olaf

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PI3K-mTOR Pathway Inhibition Exhibits Efficacy Against High-grade Glioma in Clinically Relevant Mouse Models von Lin, Fan, de Gooijer, Mark C, Hanekamp, Diana, Chandrasekaran, Gayathri, Buil, Levi C M, Thota, Nishita, Sparidans, Rolf W, Beijnen, Jos H, Würdinger, Tom, van Tellingen, Olaf

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ABCB1, ABCG2, and PTEN Determine the Response of Glioblastoma to Temozolomide and ABT-888 Therapy von FAN LIN, DE GOOIJER, Mark C, ROIG, Eloy Moreno, BUIL, Levi C. M, CHRISTNER, Susan M, BEUMER, Jan H, WÜRDINGER, Thomas, BEIJNEN, Jos H, VAN TELLINGEN, Olaf

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Buparlisib is a brain penetrable pan-PI3K inhibitor von de Gooijer, Mark C., Zhang, Ping, Buil, Levi C. M., Çitirikkaya, Ceren H., Thota, Nishita, Beijnen, Jos H., van Tellingen, Olaf

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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer von Mertens, Sander, Huismans, Maarten A., Verissimo, Carla S., Ponsioen, Bas, Overmeer, Rene, Proost, Natalie, van Tellingen, Olaf, van de Ven, Marieke, Begthel, Harry, Boj, Sylvia F., Clevers, Hans, Roodhart, Jeanine M.L., Bos, Johannes L., Snippert, Hugo J.G.

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Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity von Pogacar, Ziva, Johnson, Jackie L, Krenning, Lenno, De Conti, Giulia, Jochems, Fleur, Lieftink, Cor, Velds, Arno, Wardak, Leyma, Groot, Kelvin, Schepers, Arnout, Wang, Liqin, Song, Ji-Ying, van de Ven, Marieke, van Tellingen, Olaf, Medema, Rene H, Beijersbergen, Roderick L, Bernards, Rene, Leite de Oliveira, Rodrigo

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Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division von Maia, Ana Rita R., Linder, Simon, Song, Ji-Ying, Vaarting, Chantal, Boon, Ute, Pritchard, Colin E. J., Velds, Arno, Huijbers, Ivo J., van Tellingen, Olaf, Jonkers, Jos, Medema, René H.

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Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness von Pencheva, Nora, de Gooijer, Mark C., Vis, Daniel J., Wessels, Lodewyk F.A., Würdinger, Tom, van Tellingen, Olaf, Bernards, René

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Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation von Albers, Harald M.H.G, Dong, Anping, van Meeteren, Laurens A, Egan, David A, Sunkara, Manjula, van Tilburg, Erica W, Schuurman, Karianne, van Tellingen, Olaf, Morris, Andrew J, Smyth, Susan S, Moolenaar, Wouter H, Ovaa, Huib

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P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan von DEVRIES, Nienkea, JIN ZHAO, KROON, Emily, BUCKLE, Tessa, BEIJNEN, Jos H, VANTELLINGEN, Olaf

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