Unifying Family A GPCR Theories of Activation von TEHAN, Benjamin G, BORTOLATO, Andrea, BLANEY, Frank E, WEIR, Malcolm P, MASON, Jonathan S

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Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits von Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.

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Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X‑ray Crystallography and Computational Analysis von Rappas, Mathieu, Ali, Ammar A. E, Bennett, Kirstie A, Brown, Jason D, Bucknell, Sarah J, Congreve, Miles, Cooke, Robert M, Cseke, Gabriella, de Graaf, Chris, Doré, Andrew S, Errey, James C, Jazayeri, Ali, Marshall, Fiona H, Mason, Jonathan S, Mould, Richard, Patel, Jayesh C, Tehan, Benjamin G, Weir, Malcolm, Christopher, John A

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Structure of Class B GPCRs: new horizons for drug discovery von Bortolato, Andrea, Doré, Andrew S, Hollenstein, Kaspar, Tehan, Benjamin G, Mason, Jonathan S, Marshall, Fiona H

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Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]be... von Christopher, John A, Aves, Sarah J, Bennett, Kirstie A, Doré, Andrew S, Errey, James C, Jazayeri, Ali, Marshall, Fiona H, Okrasa, Krzysztof, Serrano-Vega, Maria J, Tehan, Benjamin G, Wiggin, Giselle R, Congreve, Miles

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Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits von Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.

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Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants von Harpsøe, Kasper, Isberg, Vignir, Tehan, Benjamin G., Weiss, Dahlia, Arsova, Angela, Marshall, Fiona H., Bräuner-Osborne, Hans, Gloriam, David E.

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Comparisons of the HBV and HIV polymerase, and antiviral resistance mutations von BARTHOLOMEUSZ, Angeline, TEHAN, Benjamin G, CHALMERS, David K

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Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918 von Stott, Lisa A., Brighton, Cheryl A., Brown, Jason, Mould, Richard, Bennett, Kirstie A., Newman, Robert, Currinn, Heather, Autore, Flavia, Higueruelo, Alicia P., Tehan, Benjamin G., MacSweeney, Cliona, O'Brien, Michael A., Watson, Steve P.

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From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease von Brown, Alastair J. H., Bradley, Sophie J., Marshall, Fiona H., Bown, Giles A., Bennett, Kirstie A., Brown, Jason, Cansfield, Julie E., Cross, David M., de Graaf, Chris, Hudson, Brian D., Dwomoh, Louis, Dias, Joao M., Errey, James C., Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J., Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C., Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M., Goonawardena, Anushka V., Morairty, Stephen R., Browning, Michael, Perini, Francesca, Dawson, Gerard R., Deakin, John F. W., Smith, Robert T., Sexton, Patrick M., Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G., Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J., Jazayeri, Ali, Cooke, Robert M., Rucktooa, Prakash, Congreve, Miles S., Weir, Malcolm, Tobin, Andrew B.

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The use of conformationally thermostabilised GPCRs in drug discovery: application to fragment, structure and biophysical techniques von Tehan, Benjamin G, Christopher, John A

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Methodologies for the Examination of Water in GPCRs von Bortolato, Andrea, Tehan, Benjamin G., Smith, Robert T., Mason, Jonathan S.

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Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids von Tehan, Benjamin G., Lloyd, Edward J., Wong, Margaret G., Pitt, Will R., Montana, John G., Manallack, David T., Gancia, Emanuela

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From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease von Brown, Alastair J.H., Bradley, Sophie J., Marshall, Fiona H., Brown, Giles A., Bennett, Kirstie A., Brown, Jason, Cansfield, Julie E., Cross, David M., de Graaf, Chris, Hudson, Brian D., Dwomoh, Louis, Dias, João M., Errey, James C., Hurrell, Edward, Liptrot, Jan, Mattedi, Giulio, Molloy, Colin, Nathan, Pradeep J., Okrasa, Krzysztof, Osborne, Greg, Patel, Jayesh C., Pickworth, Mark, Robertson, Nathan, Shahabi, Shahram, Bundgaard, Christoffer, Phillips, Keith, Broad, Lisa M., Goonawardena, Anushka V., Morairty, Stephen R., Browning, Michael, Perini, Francesca, Dawson, Gerard R., Deakin, John F.W., Smith, Robert T., Sexton, Patrick M., Warneck, Julie, Vinson, Mary, Tasker, Tim, Tehan, Benjamin G., Teobald, Barry, Christopoulos, Arthur, Langmead, Christopher J., Jazayeri, Ali, Cooke, Robert M., Rucktooa, Prakash, Congreve, Miles S., Weir, Malcolm, Tobin, Andrew B.

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A Consensus Neural Network-Based Technique for Discriminating Soluble and Poorly Soluble Compounds von Manallack, David T, Tehan, Benjamin G, Gancia, Emanuela, Hudson, Brian D, Ford, Martyn G, Livingstone, David J, Whitley, David C, Pitt, Will R

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Structure of C lass B GPCRs : new horizons for drug discovery von Bortolato, Andrea, Doré, Andrew S, Hollenstein, Kaspar, Tehan, Benjamin G, Mason, Jonathan S, Marshall, Fiona H

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Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits (Sep, 10.1038/s41467-021-25280-5, 2021) von Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.

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Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu 5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]b... von Christopher, John A., Aves, Sarah J., Bennett, Kirstie A., Doré, Andrew S., Errey, James C., Jazayeri, Ali, Marshall, Fiona H., Okrasa, Krzysztof, Serrano-Vega, Maria J., Tehan, Benjamin G., Wiggin, Giselle R., Congreve, Miles

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Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 2: Application to Amines, Anilines and Various Nitrogen Containing Heterocyclic Compounds von Tehan, Benjamin G., Lloyd, Edward J., Wong, Margaret G., Pitt, Will R., Gancia, Emanuela, Manallack, David T.

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Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties von Christopher, John A., Aves, Sarah J., Brown, Jason, Errey, James C., Klair, Suki S., Langmead, Christopher J., Mace, Oliver J., Mould, Richard, Patel, Jayesh C., Tehan, Benjamin G., Zhukov, Andrei, Marshall, Fiona H., Congreve, Miles

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