Arrested Developments: CDK4/6 Inhibitor Resistance and Alterations in the Tumor Immune Microenvironment von Teh, Jessica L F, Aplin, Andrew E

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An In Vivo Reporter to Quantitatively and Temporally Analyze the Effects of CDK4/6 Inhibitor-Based Therapies in Melanoma von Teh, Jessica L F, Purwin, Timothy J, Greenawalt, Evan J, Chervoneva, Inna, Goldberg, Allison, Davies, Michael A, Aplin, Andrew E

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Targeting PHGDH Upregulation Reduces Glutathione Levels and Resensitizes Resistant NRAS-Mutant Melanoma to MAPK Kinase Inhibition von Nguyen, Mai Q., Teh, Jessica L.F., Purwin, Timothy J., Chervoneva, Inna, Davies, Michael A., Nathanson, Katherine L., Cheng, Phil F., Levesque, Mitchell P., Dummer, Reinhard, Aplin, Andrew E.

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Playing the Melanoma Endgame von Teh, Jessica L F, Aplin, Andrew E

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Metabolic Adaptations to MEK and CDK4/6 Cotargeting in Uveal Melanoma von Teh, Jessica L. F., Purwin, Timothy J., Han, Anna, Chua, Vivian, Patel, Prem, Baqai, Usman, Liao, Connie, Bechtel, Nelisa, Sato, Takami, Davies, Michael A., Aguirre-Ghiso, Julio, Aplin, Andrew E.

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In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms von Teh, Jessica L F, Cheng, Phil F, Purwin, Timothy J, Nikbakht, Neda, Patel, Prem, Chervoneva, Inna, Ertel, Adam, Fortina, Paolo M, Kleiber, Ines, HooKim, Kim, Davies, Michael A, Kwong, Lawrence N, Levesque, Mitch P, Dummer, Reinhard, Aplin, Andrew E

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Stromal fibroblast growth factor 2 reduces the efficacy of bromodomain inhibitors in uveal melanoma von Chua, Vivian, Orloff, Marlana, Teh, Jessica LF, Sugase, Takahito, Liao, Connie, Purwin, Timothy J, Lam, Bao Q, Terai, Mizue, Ambrosini, Grazia, Carvajal, Richard D, Schwartz, Gary, Sato, Takami, Aplin, Andrew E

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Glutamatergic signaling in cellular transformation von Teh, Jessica L. F., Chen, Suzie

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Abstract A22: Effects of CDK4/6/MAPK targeting combinations on melanoma and the tumor immune microenvironment von Teh, Jessica L.F., Cheng, Phil F., Erkes, Dan E., Purwin, Timothy J., Field, Conroy, Hollingworth, Connor, Aguirre-Ghiso, Julio, Levesque, Mitch P., Dummer, Reinhard, Aplin, Andrew E.

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Targeting PHGDH upregulation reduces glutathione levels and re-sensitizes resistant NRAS mutant melanoma to MEK inhibition von Nguyen, Mai Q., Teh, Jessica L.F., Purwin, Timothy J., Chervoneva, Inna, Davies, Michael A., Nathanson, Katherine L., Cheng, Phil F., Levesque, Mitchell P., Dummer, Reinhard, Aplin, Andrew E.

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Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells von Teh, Jessica L. F., Shah, Raj, La Cava, Stephanie, Dolfi, Sonia C., Mehta, Madhura S., Kongara, Sameera, Price, Sandy, Ganesan, Shridar, Reuhl, Kenneth R., Hirshfield, Kim M., Karantza, Vassiliki, Chen, Suzie

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Metabolic adaptations to MEK and CDK4/6 co-targeting in uveal melanoma von Teh, Jessica L.F., Purwin, Timothy J., Han, Anna, Chua, Vivian, Patel, Prem, Baqai, Usman, Liao, Connie, Bechtel, Nelisa, Sato, Takami, Davies, Michael A., Aguirre-Ghiso, Julio, Aplin, Andrew E.

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Activation of CD8(+) T Cells Contributes to Antitumor Effects of CDK4/6 Inhibitors plus MEK Inhibitors von Teh, Jessica L. F., Erkes, Dan A., Cheng, Phil F., Tiago, Manoela, Wilski, Nicole A., Field, Conroy O., Chervoneva, Inna, Levesque, Mitch P., Xu, Xiaowei, Dummer, Reinhard, Aplin, Andrew E.

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Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor von Teh, Jessica L. F., Shah, Raj, Shin, Seung-Shick, Wen, Yu, Mehnert, Janice M., Goydos, James, Chen, Suzie

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Correction: In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms von Teh, Jessica L F, Cheng, Phil F, Purwin, Timothy J, Nikbakht, Neda, Patel, Prem, Chervoneva, Inna, Ertel, Adam, Fortina, Paolo M, Kleiber, Ines, HooKim, Kim, Davies, Michael A, Kwong, Lawrence N, Levesque, Mitch P, Dummer, Reinhard, Aplin, Andrew E

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A Preexisting Rare PIK3CA E545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling von Romano, Gabriele, Chen, Pei-Ling, Song, Ping, McQuade, Jennifer L, Liang, Roger J, Liu, Mingguang, Roh, Whijae, Duose, Dzifa Y, Carapeto, Fernando C L, Li, Jun, Teh, Jessica L F, Aplin, Andrew E, Chen, Merry, Zhang, Jianhua, Lazar, Alexander J, Davies, Michael A, Futreal, P Andrew, Amaria, Rodabe N, Zhang, David Y, Wargo, Jennifer A, Kwong, Lawrence N

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Metabotropic glutamate receptor 1 (mGluR1) mediates melanocyte transformation via transactivation of IGF-1 Receptor von Teh, Jessica L.F., Shah, Raj, Shin, Seung-Shick, Wen, Yu, Mehnert, Janice M., Goydos, James, Chen, Suzie

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