Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair von Polo, Sophie E., Blackford, Andrew N., Chapman, J. Ross, Baskcomb, Linda, Gravel, Serge, Rusch, Andre, Thomas, Anoushka, Blundred, Rachel, Smith, Philippa, Kzhyshkowska, Julia, Dobner, Thomas, Taylor, A. Malcolm R., Turnell, Andrew S., Stewart, Grant S., Grand, Roger J., Jackson, Stephen P.

Volltext

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo von Weston, Victoria J., Oldreive, Ceri E., Skowronska, Anna, Oscier, David G., Pratt, Guy, Dyer, Martin J.S., Smith, Graeme, Powell, Judy E., Rudzki, Zbigniew, Kearns, Pamela, Moss, Paul A.H., Taylor, A. Malcolm R., Stankovic, Tatjana

Volltext

Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial von SKOWRONSKA, Anna, PARKER, Anton, MOSS, Paul, THOMAS, Peter, OSCIER, David, STANKOVIC, Tatjana, AHMED, Gulshanara, OLDREIVE, Ceri, DAVIS, Zadie, RICHARDS, Sue, DYER, Martin, MATUTES, Estella, GONZALEZ, David, TAYLOR, A. Malcolm R

Volltext

Hypomorphic PCNA mutation underlies a human DNA repair disorder von Baple, Emma L, Chambers, Helen, Cross, Harold E, Fawcett, Heather, Nakazawa, Yuka, Chioza, Barry A, Harlalka, Gaurav V, Mansour, Sahar, Sreekantan-Nair, Ajith, Patton, Michael A, Muggenthaler, Martina, Rich, Phillip, Wagner, Karin, Coblentz, Roselyn, Stein, Constance K, Last, James I, Taylor, A Malcolm R, Jackson, Andrew P, Ogi, Tomoo, Lehmann, Alan R, Green, Catherine M, Crosby, Andrew H

Volltext

MDC1 is a mediator of the mammalian DNA damage checkpoint von Elledge, Stephen J, Stewart, Grant S, Wang, Bin, Bignell, Colin R, Taylor, A. Malcolm R

Volltext

Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome von Ogi, Tomoo, Walker, Sarah, Stiff, Tom, Hobson, Emma, Limsirichaikul, Siripan, Carpenter, Gillian, Prescott, Katrina, Suri, Mohnish, Byrd, Philip J, Matsuse, Michiko, Mitsutake, Norisato, Nakazawa, Yuka, Vasudevan, Pradeep, Barrow, Margaret, Stewart, Grant S, Taylor, A Malcolm R, O'Driscoll, Mark, Jeggo, Penny A

Volltext

Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells von Kim, Jong-Soo, Krasieva, Tatiana B, Kurumizaka, Hitoshi, Chen, David J, Taylor, A. Malcolm R, Yokomori, Kyoko

Volltext

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development von Byrd, Philip J, Stewart, Grant S, Smith, Anna, Eaton, Charlotte, Taylor, Alexander J, Guy, Chloe, Eringyte, Ieva, Fooks, Peggy, Last, James I, Horsley, Robert, Oliver, Antony W, Janic, Dragana, Dokmanovic, Lidija, Stankovic, Tatjana, Taylor, A Malcolm R

Volltext

RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling von Stewart, Grant S, Stankovic, Tatjana, Byrd, Philip J, Wechsler, Thomas, Miller, Edward S, Huissoon, Aarn, Drayson, Mark T, West, Stephen C, Elledge, Stephen J, Taylor, A. Malcolm R

Volltext

Chromosome instability syndromes von Taylor, A. Malcolm R., Rothblum-Oviatt, Cynthia, Ellis, Nathan A., Hickson, Ian D., Meyer, Stefan, Crawford, Thomas O., Smogorzewska, Agata, Pietrucha, Barbara, Weemaes, Corry, Stewart, Grant S.

Volltext

Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells von Dutton, Amanda, Woodman, Ciaran B., Chukwuma, Marilyn B., Last, James I.K., Wei, Wenbin, Vockerodt, Martina, Baumforth, Karl R.N., Flavell, Joanne R., Rowe, Martin, Taylor, A. Malcolm R., Young, Lawrence S., Murray, Paul G.

Volltext

A Role for E1B-AP5 in ATR Signaling Pathways during Adenovirus Infection von BLACKFORD, Andrew N, BRUTON, Rachel K, DIRLIK, Orkide, STEWART, Grant S, TAYLOR, A. Malcolm R, DOBNER, Thomas, GRAND, Roger J. A, TURNELL, Andrew S

Volltext

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL von Austen, Belinda, Powell, Judith E., Alvi, Azra, Edwards, Ian, Hooper, Laura, Starczynski, Jane, Taylor, A. Malcolm R., Fegan, Christopher, Moss, Paul, Stankovic, Tatjana

Volltext

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in acti... von Stankovic, Tatjana, Hubank, Mike, Cronin, Debbie, Stewart, Grant S., Fletcher, Danielle, Bignell, Colin R., Alvi, Azra J., Austen, Belinda, Weston, Victoria J., Fegan, Christopher, Byrd, Philip J., Moss, PaulA.H., Taylor, A. Malcolm R.

Volltext

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation von Blackford, Andrew N., Patel, Rakesh N., Forrester, Natalie A., Theil, Kathrin, Groitl, Peter, Stewart, Grant S., Taylor, A. Malcolm R., Morgan, Iain M., Dobner, Thomas, Grand, Roger J. A., Turnell, Andrew S., Shenk, Thomas E.

Volltext

Very mild presentation in adult with classical cellular phenotype of ataxia telangiectasia von Worth, Paul F., Srinivasan, Venkataramanan, Smith, Anna, Last, James I., Wootton, Laura L., Biggs, Paul M., Davies, Nicholas P., Carney, Ellen F., Byrd, Philip J., Taylor, A. Malcolm R.

Volltext

Specific Recruitment of Human Cohesin to Laser-induced DNA Damage von Kim, Jong-Soo, Krasieva, Tatiana B, LaMorte, Vickie, Taylor, A Malcolm R, Yokomori, Kyoko

Volltext

Immunostaining of modified histones defines high-level features of the human metaphase epigenome von Terrenoire, Edith, McRonald, Fiona, Halsall, John A, Page, Paula, Illingworth, Robert S, Taylor, A Malcolm R, Davison, Val, O'Neill, Laura P, Turner, Bryan M

Volltext

Variant Ataxia Telangiectasia: Clinical and Molecular Findings and Evaluation of Radiosensitive Phenotypes in a Patient and Relatives von Claes, Kathleen, Depuydt, Julie, Taylor, A. Malcolm R., Last, James I., Baert, Annelot, Schietecatte, Peter, Vandersickel, Veerle, Poppe, Bruce, De Leeneer, Kim, D’Hooghe, Marc, Vral, Anne

Volltext

Modeling ATM mutant proteins from missense changes confirms retained kinase activity von Barone, Giancarlo, Groom, Alix, Reiman, Anne, Srinivasan, Venkataramanan, Byrd, Philip J, Taylor, A. Malcolm R

Volltext