Viewpoint: What's the NEWS? Supporting the identification of the deteriorating patient von Tavaré, Alison

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Recognition, diagnosis, and early management of sepsis: NICE guideline von Tavaré, Alison, O'Flynn, Norma

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Implementation of the National Early Warning Score in patients with suspicion of sepsis: evaluation of a system-wide quality improvement project von Pullyblank, Anne, Tavaré, Alison, Little, Hannah, Redfern, Emma, le Roux, Hein, Inada-Kim, Matthew, Cheema, Kate, Cook, Adam

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Association between National Early Warning Scores in primary care and clinical outcomes: an observational study in UK primary and secondary care von Scott, Lauren J, Redmond, Niamh M, Tavaré, Alison, Little, Hannah, Srivastava, Seema, Pullyblank, Anne

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NEWS2 in out-of-hospital settings, the ambulance and the emergency department von Tavaré, Alison, Pullyblank, Anne, Redfern, Emma, Collen, Andy, Barker, Robert O, Gibson, Andrew

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Caring for a sick or injured child during the COVID‐19 pandemic lockdown in 2020 in the UK: An online survey of parents' experiences von Neill, Sarah, Carter, Rachel, Jones, Ray, Roland, Damian, Bayes, Natasha, Tavaré, Alison, Hughes, Joanne, Turner, Tracy, Chynoweth, Jade, Tan, Chantal, Moll, Henriette, Lakhanpaul, Monica

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Laxative use in adults with intellectual disabilities: development of prescribing guidelines von Bishop, Ruth, Laugharne, Richard, Burrows, Lisa, Ward, Sandra, Eustice, Sharon, Branford, David, Wilcock, Mike, Lamb, Kirsten, Tavare, Alison, Annesley, Charlotte, Lewis, Stephen, Voulgaropoulos, Vasileios, Sleeman, Faye, Sargent, Beth, Shankar, Rohit

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Impact of Digital Educational Interventions to Support Parents Caring for Acutely Ill Children at Home and Factors That Affect Their Use: Protocol for a Systematic Review von Milne-Ives, Madison, Neill, Sarah, Bayes, Natasha, Blair, Mitch, Blewitt, Jane, Bray, Lucy, Carrol, Enitan D, Carter, Bernie, Dawson, Rob, Dimitri, Paul, Lakhanpaul, Monica, Roland, Damian, Tavare, Alison, Meinert, Edward

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Using the recommended summary plan for emergency care and treatment (ReSPECT) in care homes: a qualitative interview study von Kesten, Joanna May, Redwood, Sabi, Pullyblank, Anne, Tavare, Alison, Pocock, Lucy, Brant, Heather, Hill, Elizabeth M, Tutaev, Mary, Shum, Rui Zhi, Banks, Jon

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Effective safety netting in acute childhood illness: an important contribution to avoiding preventable deaths von Neill, Sarah, Roland, Damian, Thompson, Matthew, Palmer-Hill, Sue, Bayes, Natasha, Mullins, Laura, Turner, Tracy, Tavaré, Alison, Lakhanpaul, Monica

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Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma von Au, Lewis, Hatipoglu, Emine, Litchfield, Kevin, Beattie, Gordon, Horswell, Stuart, Nicol, David, Mason, Robert, Del Rosario, Lyra, Edmonds, Kim, Lingard, Karla, Sarker, Sarah, Carlyle, Eleanor, Attig, Jan, Becker, Pablo D., Puccio, Ignazio, Lund, Tom, Ghorani, Ehsan, Xu, Hang, Mitchison, Miriam, Moore, David A., Proctor, Ian, Falzon, Mary, Furness, Andrew J.S., Reading, James L., Marafioti, Teresa, Abbosh, Chris, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Enfield, Katey, Huebner, Ariana, Enver, Tariq, Sinclair, Ron, Rhodes, Zoe, Moore, David, Khiroya, Reena, Ellery, Peter, Veeriah, Selvaraju, Shaw, Heather, Attard, Gert, Akther, Mita Afroza, Naceur-Lombardelli, Cristina, Manzano, Lizi, Summan, Simranpreet, Kanu, Nnenna, Ward, Sophie, Stone, Paddy, Stirling, Caroline, Spain, Lavinia, Shum, Ben, Carlyle, Eleanor, Korteweg, Justine, Chandra, Ashish, Stewart, Ruby, Iredale, Lara-Rose, Enting, Debra, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Caldas, Carlos, Fitzgerald, Rebecca, Provenzano, Elena, Cluroe, Alison, McDermott, Ultan, Tavare, Simon, Roxburgh, Patricia, Chalmers, Anthony, Fraser, Sioban, Oien, Karin, Krebs, Matt, Blackhall, Fiona, Dransfield, Jo, Le Quesne, John, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Kerr, Amy, Middleton, Gary, Webb, Joanne, Ottensmeier, Christian, Harrison, David, Hackshaw, Allan, Ledermann, Jonathan, Sharp, Abby, Farrelly, Laura, Bridger, Hayley, Kassiotis, George, Chain, Benny, Larkin, James, Swanton, Charles, Quezada, Sergio A., Turajlic, Samra, Drake, William, Fernando, Archana, Hazell, Steve, Hill, Peter, O'Brien, Tim

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Tracking the Evolution of Non–Small-Cell Lung Cancer von Jamal-Hanjani, Mariam, Wilson, Gareth A, McGranahan, Nicholas, Birkbak, Nicolai J, Watkins, Thomas B.K, Veeriah, Selvaraju, Shafi, Seema, Johnson, Diana H, Mitter, Richard, Rosenthal, Rachel, Salm, Max, Horswell, Stuart, Escudero, Mickael, Matthews, Nik, Rowan, Andrew, Chambers, Tim, Moore, David A, Turajlic, Samra, Xu, Hang, Lee, Siow-Ming, Forster, Martin D, Ahmad, Tanya, Hiley, Crispin T, Abbosh, Christopher, Falzon, Mary, Borg, Elaine, Marafioti, Teresa, Lawrence, David, Hayward, Martin, Kolvekar, Shyam, Panagiotopoulos, Nikolaos, Janes, Sam M, Thakrar, Ricky, Ahmed, Asia, Blackhall, Fiona, Summers, Yvonne, Shah, Rajesh, Joseph, Leena, Quinn, Anne M, Crosbie, Phil A, Naidu, Babu, Middleton, Gary, Langman, Gerald, Trotter, Simon, Nicolson, Marianne, Remmen, Hardy, Kerr, Keith, Chetty, Mahendran, Gomersall, Lesley, Fennell, Dean A, Nakas, Apostolos, Rathinam, Sridhar, Anand, Girija, Khan, Sajid, Russell, Peter, Ezhil, Veni, Ismail, Babikir, Irvin-Sellers, Melanie, Prakash, Vineet, Lester, Jason F, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Dentro, Stefan, Taniere, Philippe, O’Sullivan, Brendan, Lowe, Helen L, Hartley, John A, Iles, Natasha, Bell, Harriet, Ngai, Yenting, Shaw, Jacqui A, Herrero, Javier, Szallasi, Zoltan, Schwarz, Roland F, Stewart, Aengus, Quezada, Sergio A, Le Quesne, John, Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Swanton, Charles

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Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma von Ross-Innes, Caryn S, Becq, Jennifer, Warren, Andrew, Cheetham, R Keira, Northen, Helen, O'Donovan, Maria, Malhotra, Shalini, di Pietro, Massimiliano, Ivakhno, Sergii, He, Miao, Weaver, Jamie M J, Lynch, Andy G, Kingsbury, Zoya, Ross, Mark, Humphray, Sean, Bentley, David, Fitzgerald, Rebecca C

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Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance von Secrier, Maria, Li, Xiaodun, de Silva, Nadeera, Eldridge, Matthew D, Contino, Gianmarco, Bornschein, Jan, MacRae, Shona, Grehan, Nicola, O'Donovan, Maria, Miremadi, Ahmad, Yang, Tsun-Po, Bower, Lawrence, Chettouh, Hamza, Crawte, Jason, Galeano-Dalmau, Núria, Grabowska, Anna, Saunders, John, Underwood, Tim, Waddell, Nicola, Barbour, Andrew P, Nutzinger, Barbara, Achilleos, Achilleas, Edwards, Paul A W, Lynch, Andy G, Tavaré, Simon, Fitzgerald, Rebecca C

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Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses von Spencer, Sarah, Köstel Bal, Sevgi, Egner, William, Lango Allen, Hana, Raza, Syed I, Ma, Chi A, Gürel, Meltem, Zhang, Yuan, Sun, Guangping, Sabroe, Ruth A, Greene, Daniel, Rae, William, Shahin, Tala, Kania, Katarzyna, Ardy, Rico Chandra, Thian, Marini, Staples, Emily, Pecchia-Bekkum, Annika, Worrall, William P M, Stephens, Jonathan, Brown, Matthew, Tuna, Salih, York, Melanie, Shackley, Fiona, Kerrin, Diarmuid, Sargur, Ravishankar, Condliffe, Alison, Tipu, Hamid Nawaz, Kuehn, Hye Sun, Rosenzweig, Sergio D, Turro, Ernest, Tavaré, Simon, Thrasher, Adrian J, Jodrell, Duncan Ian, Smith, Kenneth G C, Boztug, Kaan, Milner, Joshua D, Thaventhiran, James E D

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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning von Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., Smith, Eric

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Hemodynamic Effects of Entry Versus Exit Tear Size and Tissue Stiffness in Simulations of Aortic Dissection von Bäumler, Kathrin, Zimmermann, Judith, Ennis, Daniel B., Marsden, Alison L., Fleischmann, Dominik

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Abstract 4555: Selection of CD3 affinity allows generation of T-cell redirecting bispecific antibodies with unique pharmacokinetic and biodistribution properties von Haber, Lauric, Olson, Kara, Babb, Robert, Kelly, Marcus, Crawford, Alison, Retter, Marc, DiLillo, David, Ullman, Erica, Finney, Jennifer, Canova, Lauren, Pawashe, Arpita, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, Dorvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Patel, Supriya, Tavare, Richard, Chen, Ya Ping, Chen, Gang, Olson, William, Thurston, Gavin, Lin, John Chia-Yang, Hermann, Aynur, Kirshner, Jessica, Smith, Eric J.

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A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation von Chiu, Danica, Tavaré, Richard, Haber, Lauric, Aina, Olulanu H, Vazzana, Kristin, Ram, Priyanka, Danton, Makenzie, Finney, Jennifer, Jalal, Sumreen, Krueger, Pamela, Giurleo, Jason T, Ma, Dangshe, Smith, Eric, Thurston, Gavin, Kirshner, Jessica R, Crawford, Alison

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Study protocol for VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a UK multicentre randomised controlled trial with an internal pilot (t... von Lim, Eric, Shackcloth, Michael, Dunning, Joel, McGonigle, Niall, Brush, Tim, Dabner, Lucy, Harris, Rosie, Mckeon, Holly E, Paramasivan, Sangeetha, Elliott, Daisy, Stokes, Elizabeth A, Wordsworth, Sarah, Blazeby, Jane, Rogers, Chris A, Lim, Eric, Rogers, Chris A, Brush, Tim, Dabner, Lucy, Phillips, Dawn, Mckeon, Holly, Harris, Rosie, Paramasivan, Sangeetha, Rojas, Alba Realpe, Stokes, Elizabeth, Blazeby, Jane, Nicholson, Andrew G, Begum, Sofina, Jordan, Simon, Sousa, Paulo De, Batchelor, Tim, Internullo, Eveline, Krishnadas, Rakesh, Casali, Gianluca, West, Doug, Bobruk, Karen, O’Donovan, Catherine, Lowe, Amelia, Nicklin, Joanna, Heron, Emma, Chambers, Jo, Houlihan, Becky, Beacham, Laura, Hudson, Heather, Tucker, Katy, Davis, Danielle, Shackcloth, Mike, Asante-Siaw, Julius, Love, Susannah, Feeney, Sarah, Murphy, Lindsey, Rosas, Almudena Duran, Young, Andrea, Paul, Ian, Latif, Hyder, Jacobs, Charlotte, Chilvers, Alison, Stephenson, Edward, Cain, Martyn, Iqbal, Nazalie, McGonigle, Niall, Jones, Lisa, Rogers, Paula, Naidu, Babu, Fallouh, Hazem, Hernandez, Luis, Kalkat, Maninder, Steyn, Richard, Oswald, Nicola, Kerr, Amy, Ferris, Charlotte, Webb, Jo, Taylor, Joanne, Bancroft, Hollie, Kadiri, Salma, Belcher, Elizabeth, Stavroulias, Dionisios, Chiara, Francesco Di, Saunders, Kathryn, Havinden-Williams, May, Ainsworth, Mark, Loubani, Mahmoud, Qadri, Syed, Dobbs, Karen, Atkin, Paul, Fellowes, Dominic, Cox, Leanne, Zamvar, Vipin, Strachan, Fiona, Stewart, Stacey, Adamson, Joy, Hunt, Ian, Licht, Peter B, Nair, Arjun, Hall, Chris, Dutton, Susan J, Kirk, Alan, Kerr, Keith, Shah, Rajesh, Qureshi, Nagmi, Treasure, Tom

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