Simple Approach to Accurately Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies after Subcutaneous Injection in Humans von Haraya, Kenta, Tachibana, Tatsuhiko

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Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering von Haraya, Kenta, Tachibana, Tatsuhiko, Igawa, Tomoyuki

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Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens von Kitazawa, Takehisa, Esaki, Keiko, Tachibana, Tatsuhiko, Ishii, Shinya, Soeda, Tetsuhiro, Muto, Atsushi, Kawabe, Yoshiki, Igawa, Tomoyuki, Tsunoda, Hiroyuki, Nogami, Keiji, Shima, Midori, Hattori, Kunihiro

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Human liver chimeric mouse and trasngenic animals are useful tools for quantitatively predicting clearance and drug-drug interactions in human von Miyake, Taiji, Nakagawa, Toshito, Tachibana, Tatsuhiko, Terao, Kimio

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Analysis of Non-linear Pharmacokinetics of P-Glycoprotein Substrates in a Microfluidic Device Using a Mathematical Model that Includes an Unstirred Water Layer (UWL) Compartment von Igarashi, Fumihiko, Nakagawa, Toshito, Shinohara, Yuka, Tachibana, Tatsuhiko

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Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human von Haraya, Kenta, Tachibana, Tatsuhiko, Nezu, Junichi

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Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity von Sampei, Zenjiro, Igawa, Tomoyuki, Soeda, Tetsuhiro, Okuyama-Nishida, Yukiko, Moriyama, Chifumi, Wakabayashi, Tetsuya, Tanaka, Eriko, Muto, Atsushi, Kojima, Tetsuo, Kitazawa, Takehisa, Yoshihashi, Kazutaka, Harada, Aya, Funaki, Miho, Haraya, Kenta, Tachibana, Tatsuhiko, Suzuki, Sachiyo, Esaki, Keiko, Nabuchi, Yoshiaki, Hattori, Kunihiro

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S3.2 - PBPK and PKPD modeling to investigate engineered antibodies von Tachibana, Tatsuhiko

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A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model von Kitazawa, Takehisa, Igawa, Tomoyuki, Sampei, Zenjiro, Muto, Atsushi, Kojima, Tetsuo, Soeda, Tetsuhiro, Yoshihashi, Kazutaka, Okuyama-Nishida, Yukiko, Saito, Hiroyuki, Tsunoda, Hiroyuki, Suzuki, Tsukasa, Adachi, Hideki, Miyazaki, Taro, Ishii, Shinya, Kamata-Sakurai, Mika, Iida, Takeo, Harada, Aya, Esaki, Keiko, Funaki, Miho, Moriyama, Chifumi, Tanaka, Eriko, Kikuchi, Yasufumi, Wakabayashi, Tetsuya, Wada, Manabu, Goto, Masaaki, Toyoda, Takeshi, Ueyama, Atsunori, Suzuki, Sachiyo, Haraya, Kenta, Tachibana, Tatsuhiko, Kawabe, Yoshiki, Shima, Midori, Yoshioka, Akira, Hattori, Kunihiro

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Quantitative prediction of CYP3A‐mediated drug–drug interactions by correctly estimating fraction metabolized using human liver chimeric mice von Miyake, Taiji, Mochizuki, Tatsuki, Nakagawa, Toshito, Nakamura, Mikiko, Emoto, Chie, Komiyama, Natsuko, Hirabayashi, Manabu, Tsuruta, Satoshi, Shimojo, Tomofumi, Terao, Kimio, Tachibana, Tatsuhiko

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Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice von Miyake, Taiji, Tsutsui, Haruka, Haraya, Kenta, Tachibana, Tatsuhiko, Morimoto, Kayoko, Takehara, Shoko, Ayabe, Miho, Kobayashi, Kaoru, Kazuki, Yasuhiro

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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody von Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi

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Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation von Haraya, Kenta, Tsutsui, Haruka, Komori, Yasunori, Tachibana, Tatsuhiko

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Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases von Fukuzawa, Taku, Sampei, Zenjiro, Haraya, Kenta, Ruike, Yoshinao, Shida-Kawazoe, Meiri, Shimizu, Yuichiro, Gan, Siok Wan, Irie, Machiko, Tsuboi, Yoshinori, Tai, Hitoshi, Sakiyama, Tetsushi, Sakamoto, Akihisa, Ishii, Shinya, Maeda, Atsuhiko, Iwayanagi, Yuki, Shibahara, Norihito, Shibuya, Mitsuko, Nakamura, Genki, Nambu, Takeru, Hayasaka, Akira, Mimoto, Futa, Okura, Yuu, Hori, Yuji, Habu, Kiyoshi, Wada, Manabu, Miura, Takaaki, Tachibana, Tatsuhiko, Honda, Kiyofumi, Tsunoda, Hiroyuki, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi

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Engineered monoclonal antibody with novel antigen-sweeping activity in vivo von Igawa, Tomoyuki, Maeda, Atsuhiko, Haraya, Kenta, Tachibana, Tatsuhiko, Iwayanagi, Yuki, Mimoto, Futa, Higuchi, Yoshinobu, Ishii, Shinya, Tamba, Shigero, Hironiwa, Naoka, Nagano, Kozue, Wakabayashi, Tetsuya, Tsunoda, Hiroyuki, Hattori, Kunihiro

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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering von Hori, Yuji, Ohmine, Ken, Katada, Hitoshi, Noguchi, Yuki, Sato, Kazuki, Nambu, Takeru, Adeline, Lam Runyi, Wan, Gan Siok, Haraya, Kenta, Ozeki, Kazuhisa, Nanami, Masahiko, Tachibana, Tatsuhiko, Sampei, Zenjiro, Kuramochi, Taichi, Nezu, Junichi, Hattori, Kunihiro, Igawa, Tomoyuki

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Estimation of Clearance and Bioavailability of Therapeutic Monoclonal Antibodies from Only Subcutaneous Injection Data in Humans Based on Comprehensive Analysis of Clinical Data von Haraya, Kenta, Tachibana, Tatsuhiko

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Translational Approach for Predicting Human Pharmacokinetics of Engineered Therapeutic Monoclonal Antibodies with Increased FcRn-Binding Mutations von Haraya, Kenta, Tachibana, Tatsuhiko

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Role of a positive regulator of root hair development, CAPRICE, in Arabidopsis root epidermal cell differentiation von Wada, Takuji, Kurata, Tetsuya, Tominaga, Rumi, Koshino-Kimura, Yoshihiro, Tachibana, Tatsuhiko, Goto, Koji, Marks, M David, Shimura, Yoshiro, Okada, Kiyotaka

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Regulation of CAPRICE transcription by MYB proteins for root epidermis differentiation in Arabidopsis von Koshino Kimura, Y.(Kyoto Univ. (Japan)), Wada, T, Tachibana, T, Tsugeki, R, Ishiguro, S, Okada, K

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