Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice von Nomura, Tetsuya, Abe, Yasuhiro, Kamada, Haruhiko, Shibata, Hiroko, Kayamuro, Hiroyuki, Inoue, Masaki, Kawara, Tomoyuki, Arita, Shuhei, Furuya, Takeshi, Yamashita, Takuya, Nagano, Kazuya, Yoshikawa, Tomoaki, Yoshioka, Yasuo, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Serada, Satoshi, Naka, Tetsuji, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

Volltext

Structure–Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant von Mukai, Yohei, Shibata, Hiroko, Nakamura, Teruya, Yoshioka, Yasuo, Abe, Yasuhiro, Nomura, Tetsuya, Taniai, Madoka, Ohta, Tsunetaka, Ikemizu, Shinji, Nakagawa, Shinsaku, Tsunoda, Shin-ichi, Kamada, Haruhiko, Yamagata, Yuriko, Tsutsumi, Yasuo

Volltext

Purification and Characterization of the Human Interleukin-18 Receptor von Torigoe, Kakuji, Ushio, Shimpei, Okura, Takanori, Kobayashi, Susumu, Taniai, Madoka, Kunikata, Toshio, Murakami, Tadatoshi, Sanou, Osamu, Kojima, Hirotada, Fujii, Mitsukiyo, Ohta, Tsunetaka, Ikeda, Masao, Ikegami, Hakuo, Kurimoto, Masashi

Volltext

Functionalization of Tumor Necrosis Factor-α Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic Window von SHIBATA, Hiroko, YOSHIOKA, Yasuo, NAKAGAWA, Shinsaku, HAYAKAWA, Takao, NAGATA, Satoshi, YAMAGATA, Yuriko, MAYUMI, Tadanori, KAMADA, Haruhiko, TSUTSUMI, Yasuo, IKEMIZU, Shinji, KOBAYASHI, Kyoko, YAMAMOTO, Yoko, MUKAI, Yohei, OKAMOTO, Takayuki, TANIAI, Madoka, KAWAMURA, Maki, ABE, Yasuhiro

Volltext

Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF: Useful Information for Designing Artificial Proteo-Antagonists von Mukai, Yohei, Nakamura, Teruya, Yoshioka, Yasuo, Shibata, Hiroko, Abe, Yasuhiro, Nomura, Tetsuya, Taniai, Madoka, Ohta, Tsunetaka, Nakagawa, Shinsaku, Tsunoda, Shin-ichi, Kamada, Haruhiko, Yamagata, Yuriko, Tsutsumi, Yasuo

Volltext

Cloning and expression of interleukin-18 binding protein von Aizawa, Yasushi, Akita, Kenji, Taniai, Madoka, Torigoe, Kakuji, Mori, Tetsuya, Nishida, Yoshihiro, Ushio, Shimpei, Nukada, Yoshiyuki, Tanimoto, Tadao, Ikegami, Hakuo, Ikeda, Masao, Kurimoto, Masashi

Volltext

Cholesteryl Pullulan Encapsulated TNF-α Nanoparticles Are an Effective Mucosal Vaccine Adjuvant against Influenza Virus von Fukuda, Shigeharu, Ariyasu, Toshio, Aga, Miho, Taniguchi, Mutsuko, Ariyasu, Harumi, Taniai, Madoka, Nagatomo, Daiki, Ohta, Tsunetaka

Volltext

Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy von Yoshioka, Yasuo, Tsutsumi, Yasuo, Kamada, Haruhiko, Kihira, Tetsuya, Tsunoda, Shin-ichi, Yamamoto, Yoko, Okamoto, Takayuki, Shibata, Hiroko, Mukai, Yohei, Taniai, Madoka, Shimizu, Tomoe, Kawamura, Maki, Abe, Yasuhiro, Nakagawa, Shinsaku, Mayumi, Tadanori

Volltext

Regulation of Candida albicans Morphogenesis by Tumor Necrosis Factor-alpha and Potential for Treatment of Oral Candidiasis von Ohta, Hitomi, Tanimoto, Tadao, Taniai, Madoka, Taniguchi, Mutsuko, Ariyasu, Toshio, Arai, Shigeyuki, Ohta, Tsunetaka, Fukuda, Shigeharu

Volltext

Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-α Antagonist von Shibata, Hiroko, Yoshioka, Yasuo, Ohkawa, Akiko, Minowa, Kyoko, Mukai, Yohei, Abe, Yasuhiro, Taniai, Madoka, Nomura, Tetsuya, Kayamuro, Hiroyuki, Nabeshi, Hiromi, Sugita, Toshiki, Imai, Sunao, Nagano, Kazuya, Yoshikawa, Tomoaki, Fujita, Takuya, Nakagawa, Shinsaku, Yamamoto, Akira, Ohta, Tsunetaka, Hayakawa, Takao, Mayumi, Tadanori, Vandenabeele, Peter, Aggarwal, Bharat B., Nakamura, Teruya, Yamagata, Yuriko, Tsunoda, Shin-ichi, Kamada, Haruhiko, Tsutsumi, Yasuo

Volltext

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF von Shibata, Hiroko, Yoshioka, Yasuo, Abe, Yasuhiro, Ohkawa, Akiko, Nomura, Tetsuya, Minowa, Kyoko, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

Volltext

Cholesteryl pullulan encapsulated TNF-[alpha] nanoparticles are an effective mucosal vaccine adjuvant against influenza virus von Nagatomo, Daiki, Taniai, Madoka, Ariyasu, Harumi, Taniguchi, Mutsuko, Aga, Miho, Ariyasu, Toshio, Ohta, Tsunetaka, Fukuda, Shigeharu

Volltext

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-α in murine hepatitis models von Shibata, Hiroko, Yoshioka, Yasuo, Ohkawa, Akiko, Abe, Yasuhiro, Nomura, Tetsuya, Mukai, Yohei, Nakagawa, Shinsaku, Taniai, Madoka, Ohta, Tsunetaka, Mayumi, Tadanori, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

Volltext

Epitopes on Cry j I and Cry j II for the human ige antibodies cross-reactive between Cupressus sempervirens and Cryptomeria japonica pollen von Madoka, Taniai, Tohru, Kayano, Rohko, Takakura, Shigeto, Yamamoto, Mitsuko, Usui, Shunsaku, Ando, Masashi, Kurimoto, Panzani, Raphael, Tyoku, Matuhasi

Volltext

Optimal site-specific PEGylation of mutant TNF-α improves its antitumor potency von Yoshioka, Yasuo, Tsutsumi, Yasuo, Ikemizu, Shinji, Yamamoto, Yoko, Shibata, Hiroko, Nishibata, Toshihide, Mukai, Yohei, Okamoto, Takayuki, Taniai, Madoka, Kawamura, Maki, Abe, Yasuhiro, Nakagawa, Shinsaku, Nagata, Satoshi, Yamagata, Yuriko, Mayumi, Tadanori

Volltext

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice: Recent Advancements of DDS research in Japan von NOMURA, Tetsuya, ABE, Yasuhiro, NAGANO, Kazuya, YOSHIKAWA, Tomoaki, YOSHIOKA, Yasuo, MUKAI, Yohei, NAKAGAWA, Shinsaku, TANIAI, Madoka, OHTA, Tsunetaka, SERADA, Satoshi, NAKA, Tetsuji, TSUNODA, Shin-Ichi, KAMADA, Haruhiko, TSUTSUMI, Yasuo, SHIBATA, Hiroko, KAYAMURO, Hiroyuki, INOUE, Masaki, KAWARA, Tomoyuki, ARITA, Shuhei, FURUYA, Takeshi, YAMASHITA, Takuya

Volltext

N-terminal amino acid sequence of a major allergen of Japanese cedar pollen ( Cry j I) von Taniai, Madoka, Ando, Shunsaku, Usui, Mitsuko, Kurimoto, Masashi, Sakaguchi, Masahiro, Inouye, Sakae, Matuhasi, Tyoku

Volltext

TNFR1-selectivity improvement of mutant TNF with antagonistic activity von Nomura, Tetsuya, Abe, Yasuhiro, Inoue, Masaki, Yoshioka, Yasuo, Kayamuro, Hiroyuki, Mukai, Yohei, Taniai, Madoka, Ohta, Tsunetaka, Nakagawa, Shinsaku, Kamada, Haruhiko, Tsunoda, Shin-ichi, Tsutsumi, Yasuo

Volltext

Creation of Interferon-α8 Mutants with Amino Acid Substitutions Against Interferon-α Receptor-2 Binding Sites Using Phage Display System and Evaluation of Their Biologic Properties... von Yamamoto, Kouzo, Taniai, Madoka, Torigoe, Kakuji, Yamamoto, Shigeto, Arai, Norie, Suemoto, Yasuo, Yoshida, Kenshi, Okura, Takanori, Mori, Tetsuya, Fujioka, Noboru, Tanimoto, Tadao, Miyata, Manabu, Ariyasu, Harumi, Ushio, Chie, Fujii, Mitsukiyo, Ariyasu, Toshio, Ikeda, Masao, Ohta, Tsunetaka, Kurimoto, Masashi, Fukuda, Shigeharu

Volltext

Metastasis-Promoting Activity of a Novel Molecule, Ag 243-5, Derived from Mycoplasma, and the Complete Nucleotide Sequence von Ushio, Shimpei, Iwaki, Kanso, Taniai, Madoka, Ohta, Tsunetaka, Fukuda, Shigeharu, Sugimura, Kazuhisa, Kurimoto, Masashi

Volltext