Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition von Lang, Jessica D, Hendricks, William P D, Orlando, Krystal A, Yin, Hongwei, Kiefer, Jeffrey, Ramos, Pilar, Sharma, Ritin, Pirrotte, Patrick, Raupach, Elizabeth A, Sereduk, Chris, Tang, Nanyun, Liang, Winnie S, Washington, Megan, Facista, Salvatore J, Zismann, Victoria L, Cousins, Emily M, Major, Michael B, Wang, Yemin, Karnezis, Anthony N, Sekulic, Aleksandar, Hass, Ralf, Vanderhyden, Barbara C, Nair, Praveen, Weissman, Bernard E, Huntsman, David G, Trent, Jeffrey M

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Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing von Stark, Mitchell S, Woods, Susan L, Gartside, Michael G, Bonazzi, Vanessa F, Dutton-Regester, Ken, Aoude, Lauren G, Chow, Donald, Sereduk, Chris, Niemi, Natalie M, Tang, Nanyun, Ellis, Jonathan J, Reid, Jeffrey, Zismann, Victoria, Tyagi, Sonika, Muzny, Donna, Newsham, Irene, Wu, YuanQing, Palmer, Jane M, Pollak, Thomas, Youngkin, David, Brooks, Bradford R, Lanagan, Catherine, Schmidt, Christopher W, Kobe, Bostjan, MacKeigan, Jeffrey P, Yin, Hongwei, Brown, Kevin M, Gibbs, Richard, Trent, Jeffrey, Hayward, Nicholas K

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High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes von Kassner, Michelle, Eaton, J. Brek, Tang, Nanyun, Petit, Joachim L., Meurice, Nathalie, Yin, Hongwei Holly, Whiteaker, Paul

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Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma von Patrón, Lilian A, Yeoman, Helen, Wilson, Sydney, Tang, Nanyun, Berens, Michael E, Gokhale, Vijay, Suzuki, Teri C

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BIOM-45. DETERMINANTS OF GBM VULNERABILITY TO INHIBITORS OF NEDD8 ACTIVATING ENZYME (NAE) von Tang, Nanyun, Hao, Yue, Berens, Michael

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STAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma von Evers, Lisa, Perez-Mancera, Pedro A, Lenkiewicz, Elizabeth, Tang, Nanyun, Aust, Daniela, Knösel, Thomas, Rümmele, Petra, Holley, Tara, Kassner, Michelle, Aziz, Meraj, Ramanathan, Ramesh K, Von Hoff, Daniel D, Yin, Holly, Pilarsky, Christian, Barrett, Michael T

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Abstract 3681: Selective vulnerability of GBM PDX to a panel of EGFR tyrosine kinase inhibitors von Tang, Nanyun, Reid, George, Miller, C Ryan, Berens, Michael E.

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Biochemical and Motile Properties of Myo1b Splice Isoforms von Lin, Tianming, Tang, Nanyun, Ostap, E. Michael

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BIOM-27. CELL-FREE DNA-BASED LIQUID BIOPSIES FOR THE REAL-TIME TRACKING OF TUMOR BURDEN AND TREATMENT RESPONSE IN GLIOBLASTOMA von Mankame, Sharvari, Kyriakidou, Maria, Tang, Nanyun, Reid, George, Berens, Michael, Brown, Christine, Portnow, Jana, Barthel, Floris

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DIPG-47. DISCOVERING A MOLECULAR BASIS FOR VULNERABILITY OF H3K27M-DMG TO HISTONE DEACETYLASE INHIBITORS von Paine, Danyelle, Hao, Yue, Tang, Nanyun, Biery, Matt, Vitanza, Nicholas, Berens, Michael

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Abstract 2984: Building an in vitro blood brain barrier model to test the influence of tight junction gene alleles on disruption by focused ultrasound to treat brain tumors von Iyer, Jayashree, Akkad, Adam, Tang, Nanyun, Berens, Michael E., Zenhausern, Frederic, Gu, Jian

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Abstract 318: Multi-omics to edge into precision medicine for DIPG von Tang, Nanyun, Leskoske, Kristin, Garcia-Mansfield, Krystine, Sharma, Ritin, Tolson, Hannah, Pirrotte, Patrick, Berens, Michael E.

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Dynamics of Myo1c (Myosin-Iβ) Lipid Binding and Dissociation von Tang, Nanyun, Lin, Tianming, Ostap, E Michael

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The Kinetic Mechanism of Myo1e (Human Myosin-IC) von El Mezgueldi, Mohammed, Tang, Nanyun, Rosenfeld, Steven S, Ostap, E Michael

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CSIG-31. MULTI-OMICS TO EDGE INTO PRECISION MEDICINE FOR DIPG von Tang, Nanyun, Leskoske, Kristin, Garcia-Mansfield, Krystine, Sharma, Ritin, Tolson, Hannah, Pirrotte, Patrick, Berens, Michael

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EXTH-17. A FOCUSED ULTRASOUND BLOOD BRAIN BARRIER DISRUPTION MODEL TO TEST THE INFLUENCE OF TIGHT JUNCTION GENES TO TREAT BRAIN TUMORS von Iyer, Jayashree, Akkad, Adam, Tang, Nanyun, Berens, Michael, Zenhausern, Frederic, Gu, Jian

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Abstract 180: Identifying signatures of vulnerability through machine learning in an umbrella trial for glioblastoma von Lee, Matthew Eric, Tang, Nanyun, Ahluwalia, Manmeet, Fonkem, Ekokobe, Fink, Karen, Dhurv, Harshil, Berens, Michael E., Peng, Sen

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BIOM-37. EXTRACELLULAR VESICLES AS A PHARMACODYNAMIC REPORTER IN GLIOBLASTOMA von DeLuca, Valerie, Tang, Nanyun, Hao, Yue, Raju, Anjali, Shaffer, Charles, Riviere-Cazaux, Cecile, Burns, Terry, Sarkaria, Jann, Parney, Ian, Pirotte, Patrick, Van Keuren-Jensen, Kendall, Berens, Michael

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Abstract 2189: Evaluating efficacy of repurposed drugs in treatment of glioblastoma von Neal, Tristan, Tang, Nanyun, Reid, George, Byron, Sara, Dhruv, Harshil, Berens, Michael

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BIOM-24. IDENTIFYING VULNERABILITY SIGNATURES THROUGH MACHINE LEARNING IN AN UMBRELLA TRIAL FOR GLIOBLASTOMA von Lee, Matthew, Tang, Nanyun, Ahluwalia, Manmeet, Fonkem, Ekokobe, Fink, Karen, Dhruv, Harshil, Berens, Michael, Peng, Sen

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