CD24 + Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation von Lee, Terence Kin Wah, Castilho, Antonia, Cheung, Vincent Chi Ho, Tang, Kwan Ho, Ma, Stephanie, Ng, Irene Oi Lin

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Aldehyde Dehydrogenase Discriminates the CD133 Liver Cancer Stem Cell Populations von Ma, Stephanie, Chan, Kwok Wah, Lee, Terence Kin-Wah, Tang, Kwan Ho, Wo, Jana Yim-Hung, Zheng, Bo-Jian, Guan, Xin-Yuan

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SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models von Fedele, Carmine, Ran, Hao, Diskin, Brian, Wei, Wei, Jen, Jayu, Geer, Mitchell J, Araki, Kiyomi, Ozerdem, Ugur, Simeone, Diane M, Miller, George, Neel, Benjamin G, Tang, Kwan Ho

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SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling von Fedele, Carmine, Li, Shuai, Teng, Kai Wen, Foster, Connor J. R., Peng, David, Ran, Hao, Mita, Paolo, Geer, Mitchell J., Hattori, Takamitsu, Koide, Akiko, Wang, Yubao, Tang, Kwan Ho, Leinwand, Joshua, Wang, Wei, Diskin, Brian, Deng, Jiehui, Chen, Ting, Dolgalev, Igor, Ozerdem, Ugur, Miller, George, Koide, Shohei, Wong, Kwok-Kin, Neel, Benjamin G.

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PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer von Diskin, Brian, Adam, Salma, Cassini, Marcelo F., Sanchez, Gustavo, Liria, Miguel, Aykut, Berk, Buttar, Chandan, Li, Eric, Sundberg, Belen, Salas, Ruben D., Chen, Ruonan, Wang, Junjie, Kim, Mirhee, Farooq, Mohammad Saad, Nguy, Susanna, Fedele, Carmine, Tang, Kwan Ho, Chen, Ting, Wang, Wei, Hundeyin, Mautin, Rossi, Juan A. Kochen, Kurz, Emma, Haq, Muhammad Israr Ul, Karlen, Jason, Kruger, Emma, Sekendiz, Zennur, Wu, Dongling, Shadaloey, Sorin A. A., Baptiste, Gillian, Werba, Gregor, Selvaraj, Shanmugapriya, Loomis, Cynthia, Wong, Kwok-Kin, Leinwand, Joshua, Miller, George

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Overriding Adaptive Resistance to Sorafenib Through Combination Therapy With Src Homology 2 Domain–Containing Phosphatase 2 Blockade in Hepatocellular Carcinoma von Leung, Carmen Oi Ning, Tong, Man, Chung, Katherine Po Sin, Zhou, Lena, Che, Noélia, Tang, Kwan Ho, Ding, Jin, Lau, Eunice Yuen Ting, Ng, Irene Oi Lin, Ma, Stephanie, Lee, Terence Kin Wah

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miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1 von Ma, Stephanie, Tang, Kwan Ho, Chan, Yuen Piu, Lee, Terence K., Kwan, Pak Shing, Castilho, Antonia, Ng, Irene, Man, Kwan, Wong, Nathalie, To, Ka-Fai, Zheng, Bo-Jian, Lai, Paul B.S., Lo, Chung Mau, Chan, Kwok Wah, Guan, Xin-Yuan

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CD133+ liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling von Tang, Kwan Ho, Ma, Stephanie, Lee, Terence K., Chan, Yuen Piu, Kwan, Pak Shing, Tong, Carol M., Ng, Irene O., Man, Kwan, To, Ka-Fai, Lai, Paul B., Lo, Chung-Mau, Guan, Xin-Yuan, Chan, Kwok Wah

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Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer von Chang, Chewei Anderson, Jen, Jayu, Jiang, Shaowen, Sayad, Azin, Mer, Arvind Singh, Brown, Kevin R, Nixon, Allison M L, Dhabaria, Avantika, Tang, Kwan Ho, Venet, David, Sotiriou, Christos, Deng, Jiehui, Wong, Kwok-Kin, Adams, Sylvia, Meyn, Peter, Heguy, Adriana, Skok, Jane A, Tsirigos, Aristotelis, Ueberheide, Beatrix, Moffat, Jason, Singh, Abhyudai, Haibe-Kains, Benjamin, Khodadadi-Jamayran, Alireza, Neel, Benjamin G

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Lupeol targets liver tumor‐initiating cells through phosphatase and tensin homolog modulation von Lee, Terence Kin Wah, Castilho, Antonia, Cheung, Vincent Chi Ho, Tang, Kwan Ho, Ma, Stephanie, Ng, Irene Oi Lin

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microRNA-616 Induces Androgen-Independent Growth of Prostate Cancer Cells by Suppressing Expression of Tissue Factor Pathway Inhibitor TFPI-2 von MA, Stephanie, YUEN PIU CHAN, PAK SHING KWAN, LEE, Terence K, MINGXIA YAN, KWAN HO TANG, MING TAT LING, VIELKIND, Juergen R, GUAN, Xin-Yuan, KWOK WAH CHAN

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A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer von KWAN HO TANG, YONG DONG DAI, TONG, Daniel K, LAW, Simon, WAH CHAN, Kwok, MA, Stephanie, XIN YUAN GUAN, MAN TONG, YUEN PIU CHAN, SHING KWAN, Pak, LI FU, YAN RU QIN, WAH TSAO, Sai, LOK LUNG, Hong, LUNG, Maria L

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Rab25 Is a Tumor Suppressor Gene with Antiangiogenic and Anti-Invasive Activities in Esophageal Squamous Cell Carcinoma von MAN TONG, KWOK WAH CHAN, GUAN, Xin-Yuan, STEPHANIE MA, BAO, Jessie Y. J, KAI YAU WONG, CHEN, Jin-Na, PAK SHING KWAN, KWAN HO TANG, LI FU, QIN, Yan-Ru, SI LOK

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Blockade of CD47‐mediated cathepsin S/protease‐activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma von Lee, Terence Kin‐Wah, Cheung, Vincent Chi‐Ho, Lu, Ping, Lau, Eunice Yuen Ting, Ma, Stephanie, Tang, Kwan Ho, Tong, Man, Lo, Jessica, Ng, Irene Oi Lin

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Distinct fibroblast functional states drive clinical outcomes in ovarian cancer and are regulated by TCF21 von Hussain, Ali, Voisin, Veronique, Poon, Stephanie, Karamboulas, Christina, Bui, Ngoc Hoang Bao, Meens, Jalna, Dmytryshyn, Julia, Ho, Victor W., Tang, Kwan Ho, Paterson, Joshua, Clarke, Blaise A., Bernardini, Marcus Q., Bader, Gary D., Neel, Benjamin G., Ailles, Laurie E.

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Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC von Tang, Kwan Ho, Li, Shuai, Khodadadi-Jamayran, Alireza, Jen, Jayu, Han, Han, Guidry, Kayla, Chen, Ting, Hao, Yuan, Fedele, Carmine, Zebala, John A, Maeda, Dean Y, Christensen, James G, Olson, Peter, Athanas, Argus, Loomis, Cynthia A, Tsirigos, Aristotelis, Wong, Kwok-Kin, Neel, Benjamin G

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Targeting HER2 Exon 20 Insertion-Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib von Han, Han, Li, Shuai, Chen, Ting, Fitzgerald, Michael, Liu, Shengwu, Peng, Chengwei, Tang, Kwan Ho, Cao, Shougen, Chouitar, Johara, Wu, Jiansheng, Peng, David, Deng, Jiehui, Gao, Zhendong, Baker, Theresa E., Li, Fei, Zhang, Hua, Pan, Yuanwang, Ding, Hailin, Hu, Hai, Pyon, Val, Thakurdin, Cassandra, Papadopoulos, Eleni, Tang, Sittinon, Gonzalvez, Francois, Chen, Haiquan, Rivera, Victor M., Brake, Rachael, Vincent, Sylvie, Wong, Kwok-Kin

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Flight, symmetry and barb angle evolution in the feathers of birds and other dinosaurs von Wang, Xia, Tang, Ho Kwan, Clarke, Julia A

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Cellular adaptation to cancer therapy along a resistance continuum von França, Gustavo S., Baron, Maayan, King, Benjamin R., Bossowski, Jozef P., Bjornberg, Alicia, Pour, Maayan, Rao, Anjali, Patel, Ayushi S., Misirlioglu, Selim, Barkley, Dalia, Tang, Kwan Ho, Dolgalev, Igor, Liberman, Deborah A., Avital, Gal, Kuperwaser, Felicia, Chiodin, Marta, Levine, Douglas A., Papagiannakopoulos, Thales, Marusyk, Andriy, Lionnet, Timothée, Yanai, Itai

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Abstract LB-338: SHP2 inhibition enhances sensitivity to MEK inhibitors in multiple resistant cancer models von Fedele, Carmine, Tang, Kwan Ho, Ran, Hao, Wei, Wei, Diskin, Brian, Miller, George, Neel, Benjamin G.

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