Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction von Shi, Lihong, Cui, Shuaiying, Engel, James D, Tanabe, Osamu

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Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective von Kuriyama, Shinichi, Metoki, Hirohito, Kikuya, Masahiro, Obara, Taku, Ishikuro, Mami, Yamanaka, Chizuru, Nagai, Masato, Matsubara, Hiroko, Kobayashi, Tomoko, Sugawara, Junichi, Tamiya, Gen, Hozawa, Atsushi, Nakaya, Naoki, Tsuchiya, Naho, Nakamura, Tomohiro, Narita, Akira, Kogure, Mana, Hirata, Takumi, Tsuji, Ichiro, Nagami, Fuji, Fuse, Nobuo, Arai, Tomohiko, Kawaguchi, Yoshio, Higuchi, Shinichi, Sakaida, Masaki, Suzuki, Yoichi, Osumi, Noriko, Nakayama, Keiko, Ito, Kiyoshi, Egawa, Shinichi, Chida, Koichi, Kodama, Eiichi, Kiyomoto, Hideyasu, Ishii, Tadashi, Tsuboi, Akito, Tomita, Hiroaki, Taki, Yasuyuki, Kawame, Hiroshi, Suzuki, Kichiya, Ishii, Naoto, Ogishima, Soichi, Mizuno, Satoshi, Takai-Igarashi, Takako, Minegishi, Naoko, Yasuda, Jun, Igarashi, Kazuhiko, Shimizu, Ritsuko, Nagasaki, Masao, Tanabe, Osamu, Koshiba, Seizo, Hashizume, Hiroaki, Motohashi, Hozumi, Tominaga, Teiji, Ito, Sadayoshi, Tanno, Kozo, Sakata, Kiyomi, Shimizu, Atsushi, Hitomi, Jiro, Sasaki, Makoto, Kinoshita, Kengo, Tanaka, Hiroshi, Kobayashi, Tadao, Kure, Shigeo, Yaegashi, Nobuo, Yamamoto, Masayuki

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Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development von Liu, Jinhua, Li, Yapu, Tong, Jingyuan, Gao, Jie, Guo, Qing, Zhang, Lingling, Wang, Bingrui, Zhao, Hui, Wang, Hongtao, Jiang, Erlie, Kurita, Ryo, Nakamura, Yukio, Tanabe, Osamu, Engel, James Douglas, Bresnick, Emery H., Zhou, Jiaxi, Shi, Lihong

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Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation von Keleku-Lukwete, Nadine, Suzuki, Mikiko, Otsuki, Akihito, Tsuchida, Kouhei, Katayama, Saori, Hayashi, Makiko, Naganuma, Eriko, Moriguchi, Takashi, Tanabe, Osamu, Engel, James Douglas, Imaizumi, Masue, Yamamoto, Masayuki

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Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis von Yamauchi, Takafumi, Ochi, Daisuke, Matsukawa, Naomi, Saigusa, Daisuke, Ishikuro, Mami, Obara, Taku, Tsunemoto, Yoshiki, Kumatani, Satsuki, Yamashita, Riu, Tanabe, Osamu, Minegishi, Naoko, Koshiba, Seizo, Metoki, Hirohito, Kuriyama, Shinichi, Yaegashi, Nobuo, Yamamoto, Masayuki, Nagasaki, Masao, Hiyama, Satoshi, Sugawara, Junichi

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FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells von Liu, Fei, Lee, Jae Y., Wei, Huijun, Tanabe, Osamu, Engel, James D., Morrison, Sean J., Guan, Jun-Lin

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Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery von Saigusa, Daisuke, Okamura, Yasunobu, Motoike, Ikuko N, Katoh, Yasutake, Kurosawa, Yasuhiro, Saijyo, Reina, Koshiba, Seizo, Yasuda, Jun, Motohashi, Hozumi, Sugawara, Junichi, Tanabe, Osamu, Kinoshita, Kengo, Yamamoto, Masayuki

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Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells von Matsuda, Yukiko, Uchimura, Arikuni, Satoh, Yasunari, Kato, Naohiro, Toshishige, Masaaki, Kajimura, Junko, Hamasaki, Kanya, Yoshida, Kengo, Hayashi, Tomonori, Noda, Asao, Tanabe, Osamu

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Genome-wide association study identifies new loci for albuminuria in the Japanese population von Okuda, Hiroshi, Okamoto, Koji, Abe, Michiaki, Ishizawa, Kota, Makino, Satoshi, Tanabe, Osamu, Sugawara, Junichi, Hozawa, Atsushi, Tanno, Kozo, Sasaki, Makoto, Tamiya, Gen, Yamamoto, Masayuki, Ito, Sadayoshi, Ishii, Tadashi

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Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adul... von Cui, Shuaiying, Kolodziej, Katarzyna E., Obara, Naoshi, Amaral-Psarris, Alexandra, Demmers, Jeroen, Shi, Lihong, Engel, James Douglas, Grosveld, Frank, Strouboulis, John, Tanabe, Osamu

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Omics research project on prospective cohort studies from the Tohoku Medical Megabank Project von Koshiba, Seizo, Motoike, Ikuko, Saigusa, Daisuke, Inoue, Jin, Shirota, Matsuyuki, Katoh, Yasutake, Katsuoka, Fumiki, Danjoh, Inaho, Hozawa, Atsushi, Kuriyama, Shinichi, Minegishi, Naoko, Nagasaki, Masao, Takai‐Igarashi, Takako, Ogishima, Soichi, Fuse, Nobuo, Kure, Shigeo, Tamiya, Gen, Tanabe, Osamu, Yasuda, Jun, Kinoshita, Kengo, Yamamoto, Masayuki

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The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation von Lee, Mary P., Tanabe, Osamu, Shi, Lihong, Jearawiriyapaisarn, Natee, Lucas, Daniel, Engel, James Douglas

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Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare von Yasuda, Jun, Kinoshita, Kengo, Katsuoka, Fumiki, Danjoh, Inaho, Sakurai-Yageta, Mika, Motoike, Ikuko N, Kuroki, Yoko, Saito, Sakae, Kojima, Kaname, Shirota, Matsuyuki, Saigusa, Daisuke, Otsuki, Akihito, Kawashima, Junko, Yamaguchi-Kabata, Yumi, Tadaka, Shu, Aoki, Yuichi, Mimori, Takahiro, Kumada, Kazuki, Inoue, Jin, Makino, Satoshi, Kuriki, Miho, Fuse, Nobuo, Koshiba, Seizo, Tanabe, Osamu, Nagasaki, Masao, Tamiya, Gen, Shimizu, Ritsuko, Takai-Igarashi, Takako, Ogishima, Soichi, Hozawa, Atsushi, Kuriyama, Shinichi, Sugawara, Junichi, Tsuboi, Akito, Kiyomoto, Hideyasu, Ishii, Tadashi, Tomita, Hiroaki, Minegishi, Naoko, Suzuki, Yoichi, Suzuki, Kichiya, Kawame, Hiroshi, Tanaka, Hiroshi, Taki, Yasuyuki, Yaegashi, Nobuo, Kure, Shigeo, Nagami, Fuji, Kosaki, Kenjiro, Sutoh, Yoichi, Hachiya, Tsuyoshi, Shimizu, Atsushi, Sasaki, Makoto, Yamamoto, Masayuki

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TRIM28 is essential for erythroblast differentiation in the mouse von Hosoya, Tomonori, Clifford, Mary, Losson, Régine, Tanabe, Osamu, Engel, James Douglas

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Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project von Saito, Sakae, Aoki, Yuichi, Tamahara, Toru, Goto, Maki, Matsui, Hiroyuki, Kawashima, Junko, Danjoh, Inaho, Hozawa, Atsushi, Kuriyama, Shinichi, Suzuki, Yoichi, Fuse, Nobuo, Kure, Shigeo, Yamashita, Riu, Tanabe, Osamu, Minegishi, Naoko, Kinoshita, Kengo, Tsuboi, Akito, Shimizu, Ritsuko, Yamamoto, Masayuki

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Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals von Yamaguchi-Kabata, Yumi, Yasuda, Jun, Uruno, Akira, Shimokawa, Kazuro, Koshiba, Seizo, Suzuki, Yoichi, Fuse, Nobuo, Kawame, Hiroshi, Tadaka, Shu, Nagasaki, Masao, Kojima, Kaname, Katsuoka, Fumiki, Kumada, Kazuki, Tanabe, Osamu, Tamiya, Gen, Yaegashi, Nobuo, Kinoshita, Kengo, Yamamoto, Masayuki, Kure, Shigeo

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Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain von Sakai, Mai, Takeuchi, Hikaru, Yu, Zhiqian, Kikuchi, Yoshie, Ono, Chiaki, Takahashi, Yuta, Ito, Fumiaki, Matsuoka, Hiroo, Tanabe, Osamu, Yasuda, Jun, Taki, Yasuyuki, Kawashima, Ryuta, Tomita, Hiroaki

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Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model von Suzuki, Mikiko, Yamazaki, Hiromi, Mukai, Harumi Y., Motohashi, Hozumi, Shi, Lihong, Tanabe, Osamu, Engel, James Douglas, Yamamoto, Masayuki

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Evaluation of reported pathogenic variants and their frequencies in a Japanese population based on a whole-genome reference panel of 2049 individuals von Yamaguchi-Kabata, Yumi, Yasuda, Jun, Tanabe, Osamu, Suzuki, Yoichi, Kawame, Hiroshi, Fuse, Nobuo, Nagasaki, Masao, Kawai, Yosuke, Kojima, Kaname, Katsuoka, Fumiki, Saito, Sakae, Danjoh, Inaho, Motoike, Ikuko N, Yamashita, Riu, Koshiba, Seizo, Saigusa, Daisuke, Tamiya, Gen, Kure, Shigeo, Yaegashi, Nobuo, Kawaguchi, Yoshio, Nagami, Fuji, Kuriyama, Shinichi, Sugawara, Junichi, Minegishi, Naoko, Hozawa, Atsushi, Ogishima, Soichi, Kiyomoto, Hideyasu, Takai-Igarashi, Takako, Kinoshita, Kengo, Yamamoto, Masayuki

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Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project von Yasuda, Jun, Katsuoka, Fumiki, Danjoh, Inaho, Kawai, Yosuke, Kojima, Kaname, Nagasaki, Masao, Saito, Sakae, Yamaguchi-Kabata, Yumi, Tadaka, Shu, Motoike, Ikuko N, Kumada, Kazuki, Sakurai-Yageta, Mika, Tanabe, Osamu, Fuse, Nobuo, Tamiya, Gen, Higasa, Koichiro, Matsuda, Fumihiko, Yasuda, Nobufumi, Iwasaki, Motoki, Sasaki, Makoto, Shimizu, Atsushi, Kinoshita, Kengo, Yamamoto, Masayuki

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