Combined Inhibition of Tumor Necrosis Factor α and Interleukin‐17 As a Therapeutic Opportunity in Rheumatoid Arthritis: Development and Characterization of a Novel Bispecific Antib... von Fischer, Jens A. A., Hueber, Axel J., Wilson, Stacy, Galm, Margarete, Baum, Wolfgang, Kitson, Christopher, Auer, Johannes, Lorenz, Stefan H., Moelleken, Jörg, Bader, Martin, Tissot, Alain C., Tan, Seng‐Lai, Seeber, Stefan, Schett, Georg

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Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication? von Huang, Ying, Staschke, Kirk, De Francesco, Raffaele, Tan, Seng-Lai

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Hepatitis C therapeutics: current status and emerging strategies von Sonenberg, Nahum, Tan, Seng-Lai, Pause, Arnim, Shi, Yuguang

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Immuno-Oncology: Cellular and Translational Approaches von Tan, Seng-Lai

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874 Development of BCA101, a bifunctional antibody capable of simultaneously disabling EGFR and TGFβ signaling, as novel single-agent immunotherapy von Boreddy, Srinivas Reddy, Nair, Reshmi, Banerjee, Arindam, Kuriakose, Anshu, Pandey, Prashant Kumar, Dey, Chaitali, Shri, Meena, Rao, Shruthi, Shivakumar, Bhadravathi Marigowda, Kuriakose, Moni Abhram, Reddy, Ram Bhupal, Suresh, Amritha, Moole, Praveen Reddy, Bughani, Usha, Tan, Seng-Lai, Nair, Pradip

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Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation von Gale, Michael, Blakely, Collin M., Kwieciszewski, Bart, Tan, Seng-Lai, Dossett, Michelle, Tang, Norina M., Korth, Marcus J., Polyak, Stephen J., Gretch, David R., Katze, Michael G.

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BCA101 Is a Tumor-Targeted Bifunctional Fusion Antibody That Simultaneously Inhibits EGFR and TGFβ Signaling to Durably Suppress Tumor Growth von Boreddy, Srinivas Reddy, Nair, Reshmi, Pandey, Prashant Kumar, Kuriakose, Anshu, Marigowda, Shivakumar Bhadravathi, Dey, Chaitali, Banerjee, Arindam, Kulkarni, Hanumant, Sagar, Milind, Krishn, Shiv Ram, Rao, Shruthi, Ar, Madhukara, Tiwari, Vinita, Alke, Bhavna, Mv, Prashantha Kumar, Shri, Meena, Dhamne, Chaitrali, Patel, Sonal, Sharma, Pinky, Periyasamy, Sankar, Bhatnagar, Jaya, Kuriakose, Moni Abraham, Reddy, Ram Bhupal, Suresh, Amritha, Sreenivas, Suma, Govindappa, Nagaraja, Moole, Praveen Reddy, Bughani, Usha, Tan, Seng-Lai, Nair, Pradip

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Systems biology and the host response to viral infection von Tan, Seng-Lai, Ganji, Gopinath, Paeper, Bryan, Proll, Sean, Katze, Michael G

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Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model von Shou, Jianyong, Bull, Christopher M, Li, Li, Qian, Hui-Rong, Wei, Tao, Luo, Shuang, Perkins, Douglas, Solenberg, Patricia J, Tan, Seng-Lai, Chen, Xin-Yi Cynthia, Roehm, Neal W, Wolos, Jeffrey A, Onyia, Jude E

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Emerging and diverse roles of protein kinase C in immune cell signalling von Tan, Seng-Lai, Parker, Peter J

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Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties von Schuepbach-Mallepell, Sonia, Das, Dolon, Willen, Laure, Vigolo, Michele, Tardivel, Aubry, Lebon, Luc, Kowalczyk-Quintas, Christine, Nys, Josquin, Smulski, Cristian, Zheng, Timothy S., Maskos, Klaus, Lammens, Alfred, Jiang, Xuliang, Hess, Henry, Tan, Seng-Lai, Schneider, Pascal

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Data for the crystal structure of APRIL–BAFF–BAFF heterotrimer von Maskos, Klaus, Lammens, Alfred, Tan, Seng-Lai, Hess, Henry, Palinsky, Wolf, Schneider, Pascal, Jiang, Xuliang

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Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system von Larkin, Jonathan, Jin, Ling, Farmen, Mark, Venable, Daryl, Huang, Ying, Tan, Seng-Lai, Glass, John I

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3‑Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models von Soth, Michael, Hermann, Johannes C, Yee, Calvin, Alam, Muzaffar, Barnett, Jim W, Berry, Pamela, Browner, Michelle F, Frank, Karl, Frauchiger, Sandra, Harris, Seth, He, Yang, Hekmat-Nejad, Mohammad, Hendricks, Than, Henningsen, Robert, Hilgenkamp, Ramona, Ho, Hoangdung, Hoffman, Ann, Hsu, Pei-Yuan, Hu, Dong-Qing, Itano, Andrea, Jaime-Figueroa, Saul, Jahangir, Alam, Jin, Sue, Kuglstatter, Andreas, Kutach, Alan K, Liao, Cheng, Lynch, Stephen, Menke, John, Niu, Linghao, Patel, Vaishali, Railkar, Aruna, Roy, Douglas, Shao, Ada, Shaw, David, Steiner, Sandra, Sun, Yongliang, Tan, Seng-Lai, Wang, Sandra, Vu, Minh Diem

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Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice von Tan, Seng-Lai, Zhao, Jingyong, Bi, Chen, Chen, Xinyi Cynthia, Hepburn, Deena L, Wang, Jian, Sedgwick, Jonathon D, Chintalacharuvu, Subba R, Na, Songqing

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Selective inhibition of spleen tyrosine kinase (SYK) with a novel orally bioavailable small molecule inhibitor, RO9021, impinges on various innate and adaptive immune responses: im... von Liao, Cheng, Hsu, Jonathan, Kim, Yong, Hu, Dong-Qing, Xu, Daigen, Zhang, Jun, Pashine, Achal, Menke, John, Whittard, Toni, Romero, Natasha, Truitt, Theresa, Slade, Michelle, Lukacs, Christine, Hermann, Johannes, Zhou, Mingyan, Lucas, Matthew, Narula, Satwant, DeMartino, Julie, Tan, Seng-Lai

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Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase von Tan, S L, Katze, M G

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The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death? von Tan, S L, Katze, M G

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How Hepatitis C Virus Counteracts the Interferon Response: The Jury Is Still out on NS5A von Tan, Seng-Lai, Katze, Michael G.

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Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization von Banga, Jaspreet, Srinivasan, Dinesh, Sun, Chia-Chi, Thompson, Cherrie D., Milletti, Francesca, Huang, Kuo-Sen, Hamilton, Shannon, Song, Su, Hoffman, Ann F., Qin, Yajuan Gu, Matta, Bharati, Lapan, Margaret, Guo, Qin, Lu, Gang, Li, Dan, Qian, Hong, Bolin, David R., Liang, Lena, Wartchow, Charles, Qiu, Jin, Downing, Michelle, Narula, Satwant, Fotouhi, Nader, Demartino, Julie A., Tan, Seng-Lai, Chen, Gang, Barnes, Betsy J.

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