Discovery of AB680: A Potent and Selective Inhibitor of CD73 von Lawson, Kenneth V, Kalisiak, Jaroslaw, Lindsey, Erick A, Newcomb, Eric T, Leleti, Manmohan Reddy, Debien, Laurent, Rosen, Brandon R, Miles, Dillon H, Sharif, Ehesan U, Jeffrey, Jenna L, Tan, Joanne B. L, Chen, Ada, Zhao, Sharon, Xu, Guifen, Fu, Lijuan, Jin, Lixia, Park, Tim W, Berry, Wade, Moschütz, Susanne, Scaletti, Emma, Sträter, Norbert, Walker, Nigel P, Young, Stephen W, Walters, Matthew J, Schindler, Uli, Powers, Jay P

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Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers von Seitz, Lisa, Jin, Lixia, Leleti, Manmohan, Ashok, Devika, Jeffrey, Jenna, Rieger, Aimee, Tiessen, Renger G., Arold, Gerhard, Tan, Joanne B. L., Powers, Jay P., Walters, Matthew J., Karakunnel, Joyson

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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity von Piovesan, Dana, Tan, Joanne B L, Becker, Annette, Banuelos, Jesus, Narasappa, Nell, DiRenzo, Daniel, Zhang, Kristen, Chen, Ada, Ginn, Elaine, Udyavar, Akshata R, Yin, Fangfang, Paprcka, Susan L, Purandare, Bhamini, Park, Timothy W, Kimura, Nikki, Kalisiak, Jaroslaw, Young, Stephen W, Powers, Jay P, Schindler, Uli, Sivick, Kelsey E, Walters, Matthew J

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Full CD34 Donor Chimerism Following CD34 Chimerism Directed Donor Lymphocyte Infusion Results in Reduced Relapse and Superior Overall Survival Compared with Mixed Chimerism Status... von Tan, Joanne BL, Curtis, David J., Muirhead, Jenny, Swain, Michael, Fleming, Shaun, Cirone, BIanca, O'Brien, Maureen, Wong, Shu Min, Inam, Shafqat, Patil, Sushrut S., Spencer, Andrew

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Sgr-1505 Is a Potent MALT1 Protease Inhibitor with a Potential Best-in-Class Profile von Yin, Wu, Ye, Min, Marshall, Netonia, Tan, Joanne BL, Paull, Evan, Nie, Zhe, Trzoss, MIchael, Krilov, Goran, Feng, Shulu, Pelletier, Robert, Bell, Jeff, Skrdla, Peter, Calkins, David, Grimes, MaryBeth, Wright, D. Hamish, Akinsanya, Karen

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A Phase 1, Open-Label, Multicenter, Dose-Escalation Study of Sgr-1505 As Monotherapy in Subjects with Mature B-Cell Malignancies von Olszewski, Adam, Kahn, David, Yoo, Brian, Tan, Joanne BL, Gupta, Vipul K, Schuck, Edgar, Nie, Zhe, Krilov, Goran, Wright, D. Hamish, Weiss, Daniel, Lachowicz, Jean, Akinsanya, Karen, Yin, Wu

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Haploidentical Donor Transplants with Cytokine Release Syndrome Have Increased Risk of Clinically Significant Early CMV Reactivation Compared with Matched Donor Transplants Receivi... von Schwarer, James, Tan, Joanne BL, Cirone, BIanca, Rush, Lily, Muirhead, Jenny, Wong, Shu Min, Inam, Shafqat, Fleming, Shaun, Patil, Sushrut S., Morrissey, C. Orla, Coutsouvelis, John, Spencer, Andrew, Curtis, David J.

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Abstract B46: Small-molecule inhibitors of ecto-nucleotidase CD73 promote activation of human CD8+ T cells and have profound effects on tumor growth and immune parameters in experi... von Tan, Joanne BL, Chen, Ada, Leleti, Manmohan, Becker, Annette, Lindsey, Erick, Kalisiak, Jaroslaw, Powers, Jay P., Young, Steve, Schindler, Ulrike, Jaen, Juan C.

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TREATMENT OF ONCOGENE-DRIVEN CANCERS von TAN JOANNE B L, UDYAVAR AKSHATA R, YOUNG STEVE W

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Severity of mucositis during allogeneic transplantation impacts post-transplant cyclosporin absorption von Tan, Joanne L. C., Wong, Eric, Bajel, Ashish, Ramanan, Radha, Lim, Andrew B. M., Ritchie, David S.

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D‐immunized blood donors who are female and who possess at least one HLA‐DRB115 allele show a propensity for high serum RhIG production von Tan, Joanne C.G., Yuan, Fang Fang, Daley, Jackie, Marks, Katherine, Flower, Robert L., Dyer, Wayne B.

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Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity von Sorge, Robert E, Trang, Tuan, Dorfman, Ruslan, Smith, Shad B, Beggs, Simon, Ritchie, Jennifer, Austin, Jean-Sebastien, Zaykin, Dmitri V, Meulen, Heather Vander, Costigan, Michael, Herbert, Teri A, Yarkoni-Abitbul, Merav, Tichauer, David, Livneh, Jessica, Gershon, Edith, Zheng, Ming, Tan, Keith, John, Sally L, Slade, Gary D, Jordan, Joanne, Woolf, Clifford J, Peltz, Gary, Maixner, William, Diatchenko, Luda, Seltzer, Ze'ev, Salter, Michael W, Mogil, Jeffrey S

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Transient commensal clonal interactions can drive tumor metastasis von Naffar-Abu Amara, Suha, Kuiken, Hendrik J., Selfors, Laura M., Butler, Timothy, Leung, Marco L., Leung, Cheuk T., Kuhn, Elaine P., Kolarova, Teodora, Hage, Carina, Ganesh, Kripa, Panayiotou, Richard, Foster, Rosemary, Rueda, Bo R., Aktipis, Athena, Spellman, Paul, Ince, Tan A., Xiu, Joanne, Oberley, Matthew, Gatalica, Zoran, Navin, Nicholas, Mills, Gordon B., Bronson, Rodrick T., Brugge, Joan S.

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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 von Kalil, Andre C, Patterson, Thomas F, Mehta, Aneesh K, Tomashek, Kay M, Wolfe, Cameron R, Ghazaryan, Varduhi, Marconi, Vincent C, Ruiz-Palacios, Guillermo M, Hsieh, Lanny, Kline, Susan, Tapson, Victor, Iovine, Nicole M, Jain, Mamta K, Sweeney, Daniel A, El Sahly, Hana M, Branche, Angela R, Regalado Pineda, Justino, Lye, David C, Sandkovsky, Uriel, Luetkemeyer, Anne F, Cohen, Stuart H, Finberg, Robert W, Jackson, Patrick E.H, Taiwo, Babafemi, Paules, Catharine I, Arguinchona, Henry, Erdmann, Nathaniel, Ahuja, Neera, Frank, Maria, Oh, Myoung-don, Kim, Eu-Suk, Tan, Seow Y, Mularski, Richard A, Nielsen, Henrik, Ponce, Philip O, Taylor, Barbara S, Larson, LuAnn, Rouphael, Nadine G, Saklawi, Youssef, Cantos, Valeria D, Ko, Emily R, Engemann, John J, Amin, Alpesh N, Watanabe, Miki, Billings, Joanne, Elie, Marie-Carmelle, Davey, Richard T, Burgess, Timothy H, Ferreira, Jennifer, Green, Michelle, Makowski, Mat, Cardoso, Anabela, de Bono, Stephanie, Bonnett, Tyler, Proschan, Michael, Deye, Gregory A, Dempsey, Walla, Nayak, Seema U, Dodd, Lori E, Beigel, John H

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Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes von Marso, Steven P, Daniels, Gilbert H, Brown-Frandsen, Kirstine, Kristensen, Peter, Mann, Johannes F.E, Nauck, Michael A, Nissen, Steven E, Pocock, Stuart, Poulter, Neil R, Ravn, Lasse S, Steinberg, William M, Stockner, Mette, Zinman, Bernard, Bergenstal, Richard M, Buse, John B

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Predictors and outcomes of dose reduction of methotrexate and cyclosporin graft‐versus‐host disease prophylaxis following allogeneic haemopoietic cell transplantation von Ramanan, Radha, Lim, Andrew B. M., Tan, Joanne L. C., Barmanray, Rahul D., Mason, Kate, Collins, Jenny, Hillman, Matthew, Szer, Jeff, Bajel, Ashish, Ritchie, David

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Utility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospita... von Punzalan, Felix Eduardo R, Aherrera, Jaime Alfonso M, de Paz-Silava, Sheriah Laine M, Mondragon, Alric V, Malundo, Anna Flor G, Tan, Joanne Jennifer E, Tantengco, Ourlad Alzeus G, Quebral, Elgin Paul B, Uy, Mary Nadine Alessandra R, Lintao, Ryan C V, Dela Rosa, Jared Gabriel L, Mercado, Maria Elizabeth P, Avenilla, Krisha Camille, Poblete, Jonnel B, Albay, Jr, Albert B, David-Wang, Aileen S, Alejandria, Marissa M

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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer von Lindstrom, Sara, Dennis, Joe, Maranian, Mel J, Brand, Judith S, Nordestgaard, Børge G, Flyger, Henrik, Rahman, Nazneen, Fletcher, Olivia, Nevanlinna, Heli, Muranen, Taru A, Aaltonen, Kirsimari, Ahsan, Habibul, John, Esther M, Gammon, Marilie D, Ursin, Giske, Schmidt, Daniel F, Gapstur, Susan M, Gaudet, Mia M, Diver, W Ryan, Schumacher, Fredrick, Hoover, Robert N, Lambrechts, Diether, Wildiers, Hans, van Limbergen, Erik, Broeks, Annegien, Cornelissen, Sten, Couch, Fergus J, Olson, Janet E, Hallberg, Emily, Meijers-Heijboer, Hanne, Ito, Hidemi, Iwata, Hiroji, Guénel, Pascal, Sanchez, Marie, Marme, Frederik, Surowy, Harald, Sohn, Christof, Van Den Berg, David, Benitez, Javier, Lu, Wei, Gao, Yu-Tang, Andrulis, Irene L, Knight, Julia A, Mulligan, Anna Marie, Sawyer, Elinor J, Tomlinson, Ian, Kerin, Michael J, Lindblom, Annika, Hollestelle, Antoinette, Collée, J Margriet, Blot, William, Signorello, Lisa B, Cai, Qiuyin, Hou, Ming-Feng, Kristensen, Vessela N, Milne, Roger L, McLean, Catriona, Peeters, Petra, Khaw, Kay-Tee, Palli, Domenico, Mortensen, Lotte Maxild, Dossus, Laure, Meindl, Alfons, Sutter, Christian, Yang, Rongxi, Muir, Kenneth, Siriwanarangsan, Pornthep, Miao, Hui, Chia, Kee Seng, Chan, Ching Wan, Fasching, Peter A, Beckmann, Matthias W, Haeberle, Lothar, Brenner, Hermann, Stegmaier, Christa, Ashworth, Alan, Schoemaker, Minouk J, Brinton, Louise, Zheng, Wei, Grip, Mervi, Brauch, Hiltrud, Radice, Paolo, Manoukian, Siranoush, Bernard, Loris, Dörk, Thilo, Hartikainen, Jaana M, Tollenaar, Robert A E M, Seynaeve, Caroline, Van Asperen, Christi J, Brennan, Paul, McKay, James, Neuhausen, Susan L, Baynes, Caroline, Ahmed, Shahana, Healey, Catherine S, Herrero, Daniel, Simard, Jacques, Chenevix-Trench, Georgia, Hall, Per, Easton, Douglas F

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JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality von Stebbing, Justin, Nievas, Gines Sanchez, Falcone, Marco, Youhanna, Sonia, Richardson, Peter, Ottaviani, Silvia, Shen, Joanne X., Sommerauer, Christian, Tiseo, Giusy, Ghiadoni, Lorenzo, Virdis, Agostino, Monzani, Fabio, Rizos, Luis Romero, Forfori, Francesco, Avendano-Cespedes, Almudena, De Marco, Salvatore, Carrozzi, Laura, Lena, Fabio, Sanchez-Jurado, Pedro Manuel, Lacerenza, Leonardo Gianluca, Cesira, Nencioni, Caldevilla-Bernardo, David, Perrella, Antonio, Niccoli, Laura, Mendez, Lourdes Saez, Matarrese, Daniela, Goletti, Delia, Tan, Yee-Joo, Monteil, Vanessa, Dranitsaris, George, Cantini, Fabrizio, Farcomeni, Alessio, Dutta, Shuchismita, Burley, Stephen K., Zhang, Haibo, Pistello, Mauro, Li, William, Romero, Marta Mas, Pretel, Fernando Andres, Simon-Talero, Rafaela Sanchez, Garcia-Molina, Rafael, Kutter, Claudia, Felce, James H., Nizami, Zehra F., Miklosi, Andras G., Penninger, Josef M., Menichetti, Francesco, Mirazimi, Ali, Abizanda, Pedro, Lauschke, Volker M.

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Validation of the Pooled Cohort equations in a long-term cohort study of Hong Kong Chinese von Lee, Chi Ho, MBBS, Woo, Yu Cho, MBChB, Lam, Joanne K.Y., MBBS, Fong, Carol H.Y., MSc, Cheung, Bernard M.Y., PhD, Lam, Karen S.L., MD, Tan, Kathryn C.B., MD

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