Evaluation of a Low‐Fat Low‐Calorie Meal on the Relative Bioavailability of Trametinib and Dabrafenib: Results From a Randomized, Open‐Label, 2‐Part Study in Healthy Participants... von Tan, Eugene Y., Pazdirkova, Marketa, Taylor, Amanda J., Singh, Namrata, Iyer, Ganesh R.

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Safety and efficacy of nazartinib (EGF816) in adults with EGFR-mutant non-small-cell lung carcinoma: a multicentre, open-label, phase 1 study von Tan, Daniel S-W, Leighl, Natasha B, Riely, Gregory J, Yang, James C-H, Sequist, Lecia V, Wolf, Juergen, Seto, Takashi, Felip, Enriqueta, Aix, Santiago P, Jonnaert, Maud, Pan, Chun, Tan, Eugene Y, Ko, Jinnie, Moody, Susan E, Kim, Dong-Wan

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Comparative Bioavailability of a Single Dose of Trametinib (TMT212) Containing 9% vs 11% Dimethyl Sulfoxide in Randomized Healthy Volunteers to Assess Long‐Term Storage at Room Tem... von Tan, Eugene Y., Chiparus, Ovidiu, Choudhury, Somesh, Kim, Christina, Lau, Mike, Ziltener, Christoph, Ilankumaran, Palanichamy

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Updated results of a phase 1 study of EGF816, a third-generation, mutant-selective EGFR tyrosine kinase inhibitor (TKI), in advanced non-small cell lung cancer (NSCLC) harboring T7... von Tan, Daniel Shao-Weng, Yang, James Chih-Hsin, Leighl, Natasha B., Riely, Gregory J., Sequist, Lecia V., Felip, Enriqueta, Seto, Takashi, Wolf, Juergen, Moody, Susan Elizabeth, Adams, Kenneth, Schmitz, Shu-Fang Hsu, Tan, Eugene Y., Kim, Dong-Wan

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Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia von Kim, Dong‐Wook, Tan, Eugene Y., Jin, Yu, Park, Sahee, Hayes, Michael, Demirhan, Eren, Schran, Horst, Wang, Yanfeng

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Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys von TAN, Eugene Y, HARTMANN, Georgy, WEI TANG, KUMAR, Sanjeev, QING CHEN, PEREIRA, Antonio, BRADLEY, Scott, DOSS, George, ZHANG, Andy Shiqiang, HO, Jonathan Z, BRAUN, Matthew P, DEAN, Dennis C

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Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans von KUMAR, Sanjeev, TAN, Eugene Y, KARANAM, Bindhu, DEAN, Dennis C, GENDRANO, Isaias Noel, GRAVES, Mark W, WAGNER, John A, KRISHNA, Rajesh, HARTMANN, Georgy, BIDDLE, Zachary, BERGMAN, Arthur J, DRU, James, HO, Jonathan Z, JONES, Allen N, STASKIEWICZ, Steve J, BRAUN, Matthew P

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Pharmacokinetics and antitumor activity of patupilone combined with midazolam or omeprazole in patients with advanced cancer von Tsimberidou, Apostolia-Maria, Lewis, Nancy, Reid, Tony, Burris, Howard, Urban, Patrick, Tan, Eugene Y., Anand, Suraj, Uehara, Cynthia, Kurzrock, Razelle

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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11β-HSD1: Novel therapeutic agents for the treatment of metabolic syndrome von Gu, Xin, Dragovic, Jasminka, Koo, Gloria C., Koprak, Sam L., LeGrand, Cheryl, Mundt, Steven S., Shah, Kashmira, Springer, Marty S., Tan, Eugene Y., Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J., Balkovec, James M., Waddell, Sherman T.

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A Phase II Study of Patupilone (EPO906) in Patients With Platinum-Resistant or Platinum-Refractory Ovarian Cancer von Smit, Willem M, Šufliarsky, Jozef, Werner, Theresa L, Dizon, Don S, Wagnerová, Maria, Hirte, Holger W, Spirtos, Nick M, Oza, Amit, Dirix, Luc, El-Hashimy, Mona, Acharyya, Suddhasatta, Tan, Eugene Y, Weber, Dirk, Schellens, Jan H.M

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KRYSTAL-2: A phase I/II trial of adagrasib (MRTX849) in combination with TNO155 in patients with advanced solid tumors with KRAS G12C mutation von Sabari, Joshua K., Park, Haeseong, Tolcher, Anthony W., Ou, Sai-Hong Ignatius, Garon, Edward B., George, Ben, Janne, Pasi A., Moody, Susan Elizabeth, Tan, Eugene Y., Sen, Suman Kumar, Peters, Dana, Yan, Xiaohong, Christensen, James G, Chi, Andrew S., Heist, Rebecca Suk

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Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome von Gu, Xin, Dragovic, Jasminka, Koo, Gloria C, Koprak, Sam L, LeGrand, Cheryl, Mundt, Steven S, Shah, Kashmira, Springer, Marty S, Tan, Eugene Y, Thieringer, Rolf, Hermanowski-Vosatka, Anne, Zokian, Hratch J, Balkovec, James M, Waddell, Sherman T

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Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development von He, Jianli, Shangguan, Xun, Zhou, Wei, Cao, Ying, Zheng, Quan, Tu, Jun, Hu, Gaolei, Liang, Zi, Jiang, Cen, Deng, Liufu, Wang, Shengdian, Yang, Wen, Zuo, Yong, Ma, Jiao, Cai, Rong, Chen, Yalan, Fan, Qiuju, Dong, Baijun, Xue, Wei, Tan, Hongsheng, Qi, Yitao, Gu, Jianmin, Su, Bing, Eugene Chin, Y., Chen, Guoqiang, Wang, Qi, Wang, Tianshi, Cheng, Jinke

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Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss von Mäe, Maarja A., He, Liqun, Nordling, Sofia, Vazquez-Liebanas, Elisa, Nahar, Khayrun, Jung, Bongnam, Li, Xidan, Tan, Bryan C., Chin Foo, Juat, Cazenave-Gassiot, Amaury, Wenk, Markus R., Zarb, Yvette, Lavina, Barbara, Quaggin, Susan E., Jeansson, Marie, Gu, Chengua, Silver, David L., Vanlandewijck, Michael, Butcher, Eugene C., Keller, Annika, Betsholtz, Christer

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Better, Faster, Cheaper: Recent Advances in Cryo-Electron Microscopy von Chua, Eugene Y.D, Mendez, Joshua H, Rapp, Micah, Ilca, Serban L, Tan, Yong Zi, Maruthi, Kashyap, Kuang, Huihui, Zimanyi, Christina M, Cheng, Anchi, Eng, Edward T, Noble, Alex J, Potter, Clinton S, Carragher, Bridget

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Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway von Li, Maolan, Zhang, Zhou, Li, Xiaoguang, Ye, Junyi, Wu, Xiangsong, Tan, Zhujun, Liu, Chang, Shen, Baiyong, Wang, Xu-An, Wu, Wenguang, Zhou, Daizhan, Zhang, Di, Wang, Ting, Liu, Bingya, Qu, Kai, Ding, Qichen, Weng, Hao, Ding, Qian, Mu, Jiasheng, Shu, Yijun, Bao, Runfa, Cao, Yang, Chen, Peizhan, Liu, Tianyu, Jiang, Lin, Hu, Yunping, Dong, Ping, Gu, Jun, Lu, Wei, Shi, Weibin, Lu, Jianhua, Gong, Wei, Tang, Zhaohui, Zhang, Yong, Wang, Xuefeng, Chin, Y Eugene, Weng, Xiaoling, Zhang, Hong, Tang, Wei, Zheng, Yonglan, He, Lin, Wang, Hui, Liu, Yun, Liu, Yingbin

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Whole-genome sequencing of patients with rare diseases in a national health system von Turro, Ernest, Astle, William J., Megy, Karyn, Gräf, Stefan, Greene, Daniel, Shamardina, Olga, Allen, Hana Lango, Sanchis-Juan, Alba, Frontini, Mattia, Thys, Chantal, Stephens, Jonathan, Mapeta, Rutendo, Burren, Oliver S., Downes, Kate, Haimel, Matthias, Tuna, Salih, Deevi, Sri V. V., Aitman, Timothy J., Bennett, David L., Calleja, Paul, Carss, Keren, Caulfield, Mark J., Chinnery, Patrick F., Dixon, Peter H., Gale, Daniel P., James, Roger, Koziell, Ania, Laffan, Michael A., Levine, Adam P., Maher, Eamonn R., Markus, Hugh S., Morales, Joannella, Morrell, Nicholas W., Mumford, Andrew D., Ormondroyd, Elizabeth, Rankin, Stuart, Rendon, Augusto, Richardson, Sylvia, Roberts, Irene, Roy, Noemi B. A., Saleem, Moin A., Smith, Kenneth G. C., Stark, Hannah, Tan, Rhea Y. Y., Themistocleous, Andreas C., Thrasher, Adrian J., Watkins, Hugh, Webster, Andrew R., Wilkins, Martin R., Williamson, Catherine, Whitworth, James, Humphray, Sean, Bentley, David R., Kingston, Nathalie, Walker, Neil, Bradley, John R., Ashford, Sofie, Penkett, Christopher J., Freson, Kathleen, Stirrups, Kathleen E., Raymond, F. Lucy, Ouwehand, Willem H.

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Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese von Tang, Clara S., Zhang, He, Cheung, Chloe Y. Y., Xu, Ming, Ho, Jenny C. Y., Zhou, Wei, Cherny, Stacey S., Zhang, Yan, Holmen, Oddgeir, Au, Ka-Wing, Yu, Haiyi, Xu, Lin, Jia, Jia, Porsch, Robert M., Sun, Lijie, Xu, Weixian, Zheng, Huiping, Wong, Lai-Yung, Mu, Yiming, Dou, Jingtao, Fong, Carol H. Y., Wang, Shuyu, Hong, Xueyu, Dong, Liguang, Liao, Yanhua, Wang, Jiansong, Lam, Levina S. M., Su, Xi, Yan, Hua, Yang, Min-Lee, Chen, Jin, Siu, Chung-Wah, Xie, Gaoqiang, Woo, Yu-Cho, Wu, Yangfeng, Tan, Kathryn C. B., Hveem, Kristian, Cheung, Bernard M. Y., Zöllner, Sebastian, Xu, Aimin, Eugene Chen, Y, Jiang, Chao Qiang, Zhang, Youyi, Lam, Tai-Hing, Ganesh, Santhi K., Huo, Yong, Sham, Pak C., Lam, Karen S. L., Willer, Cristen J., Tse, Hung-Fat, Gao, Wei

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Identification of a cellularly active SIRT6 allosteric activator von Huang, Zhimin, Zhao, Junxing, Deng, Wei, Chen, Yingyi, Shang, Jialin, Song, Kun, Zhang, Lu, Wang, Chengxiang, Lu, Shaoyong, Yang, Xiuyan, He, Bin, Min, Jinrong, Hu, Hao, Tan, Minjia, Xu, Jianrong, Zhang, Qiufen, Zhong, Jie, Sun, Xiaoxiang, Mao, Zhiyong, Lin, Houwen, Xiao, Mingzhe, Chin, Y Eugene, Jiang, Hualiang, Xu, Ying, Chen, Guoqiang, Zhang, Jian

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Acute hyperhidrosis and postural tachycardia in a COVID-19 patient von Umapathi, Thirugnanam, Poh, Mervyn Q. W., Fan, Bingwen Eugene, Li, Ki Fung Cliff, George, Julie, Tan, Jackie Y. L.

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