Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes von Drilon, Alexander, Hu, Zishuo I., Lai, Gillianne G. Y., Tan, Daniel S. W.

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Novel therapeutic targets on the horizon for lung cancer von Tan, Wan-Ling, MRCP, Jain, Amit, MMed, Takano, Angela, MD, Newell, Evan W, PhD, Iyer, N Gopalakrishna, MD, Lim, Wan-Teck, MRCP, Tan, Eng-Huat, MMed, Zhai, Weiwei, PhD, Hillmer, Axel M, PhD, Tam, Wai-Leong, PhD, Tan, Daniel S W, Dr

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First-line ceritinib versus platinum-based chemotherapy in advanced ALK -rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study von Soria, Jean-Charles, Prof, Tan, Daniel S W, MD, Chiari, Rita, MD, Wu, Yi-Long, Prof, Paz-Ares, Luis, Prof, Wolf, Juergen, Prof, Geater, Sarayut L, MD, Orlov, Sergey, Prof, Cortinovis, Diego, MD, Yu, Chong-Jen, Prof, Hochmair, Maximillian, MD, Cortot, Alexis B, Prof, Tsai, Chun-Ming, Prof, Moro-Sibilot, Denis, MD, Campelo, Rosario G, MD, McCulloch, Tracey, MSc, Sen, Paramita, PhD, Dugan, Margaret, MD, Pantano, Serafino, PhD, Branle, Fabrice, MD, Massacesi, Cristian, MD, de Castro, Gilberto, MD

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Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis von Quah, Hong Sheng, Cao, Elaine Yiqun, Suteja, Lisda, Li, Constance H., Leong, Hui Sun, Chong, Fui Teen, Gupta, Shilpi, Arcinas, Camille, Ouyang, John F., Ang, Vivian, Celhar, Teja, Zhao, Yunqian, Tay, Hui Chen, Chan, Jerry, Takahashi, Takeshi, Tan, Daniel S. W., Biswas, Subhra K., Rackham, Owen J. L., Iyer, N. Gopalakrishna

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Activity and safety of ceritinib in patients with ALK -rearranged non-small-cell lung cancer (ASCEND-1): updated results from the multicentre, open-label, phase 1 trial von Kim, Dong-Wan, MD, Mehra, Ranee, MD, Tan, Daniel S W, MD, Felip, Enriqueta, MD, Chow, Laura Q M, MD, Camidge, D Ross, Prof, Vansteenkiste, Johan, Prof, Sharma, Sunil, Prof, De Pas, Tommaso, MD, Riely, Gregory J, MD, Solomon, Benjamin J, MBBS, Wolf, Jürgen, Prof, Thomas, Michael, Prof, Schuler, Martin, Prof, Liu, Geoffrey, MD, Santoro, Armando, Prof, Sutradhar, Santosh, PhD, Li, Siyu, PhD, Szczudlo, Tomasz, MD, Yovine, Alejandro, MD, Shaw, Alice T, Dr

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Toxin Mediates Sepsis Caused by Methicillin-Resistant Staphylococcus epidermidis von Qin, Li, Da, Fei, Fisher, Emilie L, Tan, Daniel C S, Nguyen, Thuan H, Fu, Chih-Lung, Tan, Vee Y, McCausland, Joshua W, Sturdevant, Daniel E, Joo, Hwang-Soo, Queck, Shu Y, Cheung, Gordon Y C, Otto, Michael

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Capmatinib in MET Exon 14–Mutated or MET-Amplified Non–Small-Cell Lung Cancer von Wolf, Jürgen, Seto, Takashi, Han, Ji-Youn, Reguart, Noemi, Garon, Edward B, Groen, Harry J.M, Tan, Daniel S.W, Hida, Toyoaki, de Jonge, Maja, Orlov, Sergey V, Smit, Egbert F, Souquet, Pierre-Jean, Vansteenkiste, Johan, Hochmair, Maximilian, Felip, Enriqueta, Nishio, Makoto, Thomas, Michael, Ohashi, Kadoaki, Toyozawa, Ryo, Overbeck, Tobias R, de Marinis, Filippo, Kim, Tae-Min, Laack, Eckart, Robeva, Anna, Le Mouhaer, Sylvie, Waldron-Lynch, Maeve, Sankaran, Banu, Balbin, O. Alejandro, Cui, Xiaoming, Giovannini, Monica, Akimov, Mikhail, Heist, Rebecca S

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Ceritinib in ALK-Rearranged Non–Small-Cell Lung Cancer von Shaw, Alice T, Kim, Dong-Wan, Mehra, Ranee, Tan, Daniel S.W, Felip, Enriqueta, Chow, Laura Q.M, Camidge, D. Ross, Vansteenkiste, Johan, Sharma, Sunil, De Pas, Tommaso, Riely, Gregory J, Solomon, Benjamin J, Wolf, Juergen, Thomas, Michael, Schuler, Martin, Liu, Geoffrey, Santoro, Armando, Lau, Yvonne Y, Goldwasser, Meredith, Boral, Anthony L, Engelman, Jeffrey A

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Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials von Drilon, Alexander, Siena, Salvatore, Dziadziuszko, Rafal, Barlesi, Fabrice, Krebs, Matthew G, Shaw, Alice T, de Braud, Filippo, Rolfo, Christian, Ahn, Myung-Ju, Wolf, Jürgen, Seto, Takashi, Cho, Byoung Chul, Patel, Manish R, Chiu, Chao-Hua, John, Thomas, Goto, Koichi, Karapetis, Christos S, Arkenau, Hendrick-Tobias, Kim, Sang-We, Ohe, Yuichiro, Li, Yu-Chung, Chae, Young K, Chung, Christine H, Otterson, Gregory A, Murakami, Haruyasu, Lin, Chia-Chi, Tan, Daniel S W, Prenen, Hans, Riehl, Todd, Chow-Maneval, Edna, Simmons, Brian, Cui, Na, Johnson, Ann, Eng, Susan, Wilson, Timothy R, Doebele, Robert C

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Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study von Gainor, Justin F, Curigliano, Giuseppe, Kim, Dong-Wan, Lee, Dae Ho, Besse, Benjamin, Baik, Christina S, Doebele, Robert C, Cassier, Philippe A, Lopes, Gilberto, Tan, Daniel S W, Garralda, Elena, Paz-Ares, Luis G, Cho, Byoung Chul, Gadgeel, Shirish M, Thomas, Michael, Liu, Stephen V, Taylor, Matthew H, Mansfield, Aaron S, Zhu, Viola W, Clifford, Corinne, Zhang, Hui, Palmer, Michael, Green, Jennifer, Turner, Christopher D, Subbiah, Vivek

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Progression-Free and Overall Survival in ALK-Positive NSCLC Patients Treated with Sequential Crizotinib and Ceritinib von Gainor, Justin F, Tan, Daniel S W, De Pas, Tomasso, Solomon, Benjamin J, Ahmad, Aziah, Lazzari, Chiara, de Marinis, Filippo, Spitaleri, Gianluca, Schultz, Katherine, Friboulet, Luc, Yeap, Beow Y, Engelman, Jeffrey A, Shaw, Alice T

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Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma von Tan, Daniel S W, Chong, Fui Teen, Leong, Hui Sun, Toh, Shen Yon, Lau, Dawn P, Kwang, Xue Lin, Zhang, Xiaoqian, Sundaram, Gopinath M, Tan, Gek San, Chang, Mei Mei, Chua, Boon Tin, Lim, Wan Teck, Tan, Eng Huat, Ang, Mei Kim, Lim, Tony K H, Sampath, Prabha, Chowbay, Balram, Skanderup, Anders J, DasGupta, Ramanuj, Iyer, N Gopalakrishna

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Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies von Bauer, Sebastian, Demetri, George D., Halilovic, Ensar, Dummer, Reinhard, Meille, Christophe, Tan, Daniel S. W., Guerreiro, Nelson, Jullion, Astrid, Ferretti, Stephane, Jeay, Sebastien, Van Bree, Laurence, Hourcade-Potelleret, Florence, Wuerthner, Jens U., Fabre, Claire, Cassier, Philippe A.

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Targeted Therapies for Lung Cancer Patients With Oncogenic Driver Molecular Alterations von Tan, Aaron C, Tan, Daniel S W

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Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing von Nahar, Rahul, Zhai, Weiwei, Zhang, Tong, Takano, Angela, Khng, Alexis J., Lee, Yin Yeng, Liu, Xingliang, Lim, Chong Hee, Koh, Tina P. T., Aung, Zaw Win, Lim, Tony Kiat Hon, Veeravalli, Lavanya, Yuan, Ju, Teo, Audrey S. M., Chan, Cheryl X., Poh, Huay Mei, Chua, Ivan M. L., Liew, Audrey Ann, Lau, Dawn Ping Xi, Kwang, Xue Lin, Toh, Chee Keong, Lim, Wan-Teck, Lim, Bing, Tam, Wai Leong, Tan, Eng-Huat, Hillmer, Axel M., Tan, Daniel S. W.

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PLP1-Targeting Antisense Oligonucleotides Improve FOXG1 Syndrome Mice von Tan, Daniel C S, Jung, Seonghee, Deng, Yuanyuan, Morey, Nicolle, Chan, Gabriella, Bongers, Andre, Ke, Yazi D, Ittner, Lars M, Delerue, Fabien

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Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases von Tan, Wan-Ling, Ng, Quan Sing, Lim, Cindy, Tan, Eng Huat, Toh, Chee Keong, Ang, Mei-Kim, Kanesvaran, Ravindran, Jain, Amit, Tan, Daniel S W, Lim, Darren Wan-Teck

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Risk of hepatitis B virus (HBV) reactivation in hepatitis B surface antigen negative/hepatitis B core antibody positive patients receiving rituximab-containing combination chemothe... von Koo, Yu Xuan, Tay, Matthew, Teh, Yii Ean, Teng, David, Tan, Daniel S. W., Tan, Iain B. H., Tai, David W. M., Quek, Richard, Tao, Miriam, Lim, Soon Thye

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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer von Ng, King Pan, Hillmer, Axel M, Chuah, Charles T H, Juan, Wen Chun, Ko, Tun Kiat, Teo, Audrey S M, Ariyaratne, Pramila N, Takahashi, Naoto, Sawada, Kenichi, Fei, Yao, Soh, Sheila, Lee, Wah Heng, Huang, John W J, Allen, John C, Woo, Xing Yi, Nagarajan, Niranjan, Kumar, Vikrant, Thalamuthu, Anbupalam, Poh, Wan Ting, Ang, Ai Leen, Mya, Hae Tha, How, Gee Fung, Yang, Li Yi, Koh, Liang Piu, Chowbay, Balram, Chang, Chia-Tien, Nadarajan, Veera S, Chng, Wee Joo, Than, Hein, Lim, Lay Cheng, Goh, Yeow Tee, Zhang, Shenli, Poh, Dianne, Tan, Patrick, Seet, Ju-Ee, Ang, Mei-Kim, Chau, Noan-Minh, Ng, Quan-Sing, Tan, Daniel S W, Soda, Manabu, Isobe, Kazutoshi, Nöthen, Markus M, Wong, Tien Y, Shahab, Atif, Ruan, Xiaoan, Cacheux-Rataboul, Valère, Sung, Wing-Kin, Tan, Eng Huat, Yatabe, Yasushi, Mano, Hiroyuki, Soo, Ross A, Chin, Tan Min, Lim, Wan-Teck, Ruan, Yijun, Ong, S Tiong

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Anti-cancer drug resistance: Understanding the mechanisms through the use of integrative genomics and functional RNA interference von Tan, Daniel S.-W, Gerlinger, Marco, Teh, Bin-Tean, Swanton, Charles

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