Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry von Talele, Tanaji T

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Structural basis for allosteric PARP-1 retention on DNA breaks von Zandarashvili, Levani, Langelier, Marie-France, Velagapudi, Uday Kiran, Hancock, Mark A., Steffen, Jamin D., Billur, Ramya, Hannan, Zain M., Wicks, Andrew J., Krastev, Dragomir B., Pettitt, Stephen J., Lord, Christopher J., Talele, Tanaji T., Pascal, John M., Black, Ben E.

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Opportunities for Tapping into Three-Dimensional Chemical Space through a Quaternary Carbon von Talele, Tanaji T

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The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules von Talele, Tanaji T

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The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin von Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.

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Acetylene Group, Friend or Foe in Medicinal Chemistry von Talele, Tanaji T.

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Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1) von Chufan, Eduardo E, Kapoor, Khyati, Sim, Hong-May, Singh, Satyakam, Talele, Tanaji T, Durell, Stewart R, Ambudkar, Suresh V

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Characterization of Solid Dispersion of Itraconazole Prepared by Solubilization in Concentrated Aqueous Solutions of Weak Organic Acids and Drying von Parikh, Tapan, Sandhu, Harpreet K., Talele, Tanaji T., Serajuddin, Abu T. M.

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Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development von Dana, Dibyendu, Das, Tuhin, Choi, Athena, Bhuiyan, Ashif I, Das, Tirtha K, Talele, Tanaji T, Pathak, Sanjai K

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Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models von Tiwari, Amit K, Sodani, Kamlesh, Dai, Chun-ling, Abuznait, Alaa H, Singh, Satyakam, Xiao, Zhi-Jie, Patel, Atish, Talele, Tanaji T, Fu, Liwu, Kaddoumi, Amal, Gallo, James M, Chen, Zhe-Sheng

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Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance von ZHI SHI, TIWARI, Amit K, TALELE, Tanaji T, FU, Li-Wu, CHEN, Zhe-Sheng, SHUKLA, Suneet, ROBEY, Robert W, SINGH, Satyakam, KIM, In-Wha, BATES, Susan E, XINGXIANG PENG, ABRAHAM, Loana, AMBUDKAR, Suresh V

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Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters von Zhang, Yun-Kai, Zhang, Guan-Nan, Wang, Yi-Jun, Patel, Bhargav A., Talele, Tanaji T., Yang, Dong-Hua, Chen, Zhe-Sheng

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Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)‑Valine-Derived Thiazole Amino... von Singh, Satyakam, Prasad, Nagarajan Rajendra, Chufan, Eduardo E, Patel, Bhargav A, Wang, Yi-Jun, Chen, Zhe-Sheng, Ambudkar, Suresh V, Talele, Tanaji T

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Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells von Huang, Xiao-Cong, Xiao, Xue, Zhang, Yun-Kai, Talele, Tanaji T, Salim, Angela A, Chen, Zhe-Sheng, Capon, Robert J

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In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates von AbdelKhalek, Ahmed, Ashby, Jr, Charles R, Patel, Bhargav A, Talele, Tanaji T, Seleem, Mohamed N

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2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function von Wang, Mao, Gauthier, Alex G., Kennedy, Thomas P., Wang, Haichao, Velagapudi, Uday Kiran, Talele, Tanaji T., Lin, Mosi, Wu, Jiaqi, Daley, LeeAnne, Yang, Xiaojing, Patel, Vivek, Mun, Sung Soo, Ashby, Charles R., Mantell, Lin L.

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Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2H)‑one-7-carboxamide Derivatives as Poly(ADP-ribose)polymera... von Patel, Maulik R, Bhatt, Aaditya, Steffen, Jamin D, Chergui, Adel, Murai, Junko, Pommier, Yves, Pascal, John M, Trombetta, Louis D, Fronczek, Frank R, Talele, Tanaji T

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GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance von Sodani, Kamlesh, Tiwari, Amit K., Singh, Satyakam, Patel, Atish, Xiao, Zhi-Jie, Chen, Jun-Jiang, Sun, Yue-Li, Talele, Tanaji T., Chen, Zhe-Sheng

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2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase von Küçükgüzel, İlkay, Satılmış, Gökhan, Gurukumar, K.R., Basu, Amartya, Tatar, Esra, Nichols, Daniel B., Talele, Tanaji T., Kaushik-Basu, Neerja

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Correction to: 2‑O, 3‑O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1‑compromised macrophage function... von Wang, Mao, Gauthier, Alex G., Kennedy, Thomas P., Wang, Haichao, Velagapudi, Uday Kiran, Talele, Tanaji T., Lin, Mosi, Wu, Jiaqi, Daley, LeeAnne, Yang, Xiaojing, Patel, Vivek, Mun, Sung Soo, Ashby, Charles R., Mantell, Lin L.

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