Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1 von Suzuki, Takafumi, Muramatsu, Aki, Saito, Ryota, Iso, Tatsuro, Shibata, Takahiro, Kuwata, Keiko, Kawaguchi, Shin-ichi, Iwawaki, Takao, Adachi, Saki, Suda, Hiromi, Morita, Masanobu, Uchida, Koji, Baird, Liam, Yamamoto, Masayuki

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Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability von Iwawaki, Takao, Akai, Ryoko, Yamanaka, Shinya, Kohno, Kenji

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Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress von Sekiguchi, Akiko, Motegi, Sei-Ichiro, Fujiwara, Chisako, Yamazaki, Sahori, Inoue, Yuta, Uchiyama, Akihiko, Akai, Ryoko, Iwawaki, Takao, Ishikawa, Osamu

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Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells von Liu, Lu, Zhao, Meiling, Jin, Xi, Ney, Gina, Yang, Kevin B, Peng, Fanglue, Cao, Jin, Iwawaki, Takao, Del Valle, Juan, Chen, Xi, Li, Qing

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Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions von Xu, Longyong, Liu, Xia, Peng, Fanglue, Zhang, Weijie, Zheng, Liting, Ding, Yao, Gu, Tianpeng, Lv, Kaosheng, Wang, Jin, Ortinau, Laura, Hu, Tianyuan, Shi, Xiangguo, Shi, Guojun, Shang, Ge, Sun, Shengyi, Iwawaki, Takao, Ji, Yewei, Li, Wei, Rosen, Jeffrey M., Zhang, Xiang H.-F., Park, Dongsu, Adoro, Stanley, Catic, Andre, Tong, Wei, Qi, Ling, Nakada, Daisuke, Chen, Xi

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Paneth cells as a site of origin for intestinal inflammation von Adolph, Timon E., Tomczak, Michal F., Niederreiter, Lukas, Ko, Hyun-Jeong, Böck, Janne, Martinez-Naves, Eduardo, Glickman, Jonathan N., Tschurtschenthaler, Markus, Hartwig, John, Hosomi, Shuhei, Flak, Magdalena B., Cusick, Jennifer L., Kohno, Kenji, Iwawaki, Takao, Billmann-Born, Susanne, Raine, Tim, Bharti, Richa, Lucius, Ralph, Kweon, Mi-Na, Marciniak, Stefan J., Choi, Augustine, Hagen, Susan J., Schreiber, Stefan, Rosenstiel, Philip, Kaser, Arthur, Blumberg, Richard S.

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IRE1α–XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain von Chopra, Sahil, Giovanelli, Paolo, Alvarado-Vazquez, Perla Abigail, Alonso, Sara, Song, Minkyung, Sandoval, Tito A., Chae, Chang-Suk, Tan, Chen, Fonseca, Miriam M., Gutierrez, Silvia, Jimenez, Leandro, Subbaramaiah, Kotha, Iwawaki, Takao, Kingsley, Philip J., Marnett, Lawrence J., Kossenkov, Andrew V., Crespo, Mariano Sanchez, Dannenberg, Andrew J., Glimcher, Laurie H., Romero-Sandoval, E. Alfonso, Cubillos-Ruiz, Juan R.

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Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis von Tschurtschenthaler, Markus, Adolph, Timon E, Ashcroft, Jonathan W, Niederreiter, Lukas, Bharti, Richa, Saveljeva, Svetlana, Bhattacharyya, Joya, Flak, Magdalena B, Shih, David Q, Fuhler, Gwenny M, Parkes, Miles, Kohno, Kenji, Iwawaki, Takao, Janneke van der Woude, C, Harding, Heather P, Smith, Andrew M, Peppelenbosch, Maikel P, Targan, Stephan R, Ron, David, Rosenstiel, Philip, Blumberg, Richard S, Kaser, Arthur

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Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α von Duwaerts, Caroline C., Siao, Kevin, Soon, Russell K., Her, Chris, Iwawaki, Takao, Kohno, Kenji, Mattis, Aras N., Maher, Jacquelyn J.

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Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model von Yamazaki, Sahori, Sekiguchi, Akiko, Uchiyama, Akihiko, Fujiwara, Chisako, Inoue, Yuta, Yokoyama, Yoko, Ogino, Sachiko, Torii, Ryoko, Hosoi, Mari, Akai, Ryoko, Iwawaki, Takao, Ishikawa, Osamu, Motegi, Sei-ichiro

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IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival von Batista, Alyssa, Rodvold, Jeffrey J, Xian, Su, Searles, Stephen C, Lew, Alyssa, Iwawaki, Takao, Almanza, Gonzalo, Waller, T Cameron, Lin, Jonathan, Jepsen, Kristen, Carter, Hannah, Zanetti, Maurizio

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IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level von Iwawaki, Takao, Akai, Ryoko, Kohno, Kenji

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CHOP is a critical regulator of acetaminophen-induced hepatotoxicity von Uzi, Dotan, Barda, Liran, Scaiewicz, Viviana, Mills, Maya, Mueller, Tobias, Gonzalez-Rodriguez, Agueda, Valverde, Angela M, Iwawaki, Takao, Nahmias, Yaacov, Xavier, Ramnik, Chung, Ray T, Tirosh, Boaz, Shibolet, Oren

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ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response von Chapple, Richard H, Hu, Tianyuan, Tseng, Yu-Jung, Liu, Lu, Kitano, Ayumi, Luu, Victor, Hoegenauer, Kevin A, Iwawaki, Takao, Li, Qing, Nakada, Daisuke

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The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism von Roy, Anirban, Tomaz da Silva, Meiricris, Bhat, Raksha, Bohnert, Kyle R, Iwawaki, Takao, Kumar, Ashok

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Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β von Oikawa, Daisuke, Kitamura, Akira, Kinjo, Masataka, Iwawaki, Takao

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IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis von Jiang, Dadi, Guo, Youming, Wang, Tianyu, Wang, Liang, Yan, Yuelong, Xia, Ling, Bam, Rakesh, Yang, Zhifen, Lee, Hyemin, Iwawaki, Takao, Gan, Boyi, Koong, Albert C.

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Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress von Nakato, Ryosuke, Ohkubo, Yu, Konishi, Akari, Shibata, Mari, Kaneko, Yuki, Iwawaki, Takao, Nakamura, Tomohiro, Lipton, Stuart A., Uehara, Takashi

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Necrotic Cell Sensor Clec4e Promotes a Proatherogenic Macrophage Phenotype Through Activation of the Unfolded Protein Response von Clément, Marc, Basatemur, Gemma, Masters, Leanne, Baker, Lauren, Bruneval, Patrick, Iwawaki, Takao, Kneilling, Manfred, Yamasaki, Sho, Goodall, Jane, Mallat, Ziad

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Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells von Robblee, Megan M., Kim, Charles C., Abate, Jess Porter, Valdearcos, Martin, Sandlund, Karin L.M., Shenoy, Meera K., Volmer, Romain, Iwawaki, Takao, Koliwad, Suneil K.

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