41541 Guselkumab improves psoriasis, sexuality and stigmatization through week 28 – Results from the real-life G-EPOSS study von Kirsten, Natalia, Mortazawi, Dariusch, Schadeck, Tobias, Jacobsen, Simmy, Makuc, Judita, Behrens, Juliane, Tabori, Sarah, Gerdes, Sascha

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52808 Guselkumab improves perceived stigmatization in moderate-to-severe psoriasis patients, including obese patients and patients with short disease duration: Results from the rea... von Gerdes, Sascha, Zimmer, Sebastian, Schwinn, Andreas, Ostendorf, Rolf, Jacobsen, Simmy, Makuc, Judita, Trenkler, Nina, Behrens, Juliane, Tabori, Sarah, Mortazawi, Dariusch

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53723 Guselkumab improves moderate-to-severe psoriasis and patient satisfaction leading to high patient benefit in a real-life setting: Results from the G-EPOSS study through Week... von Gerdes, Sascha, Zimmer, Sebastian, Schwinn, Andreas, Ostendorf, Rolf, Jacobsen, Simmy, Makuc, Judita, Trenkler, Nina, Behrens, Juliane, Tabori, Sarah, Mortazawi, Dariusch

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52880 Guselkumab improves sexual health in patients with moderate-to-severe psoriasis, including patients across different age and weight groups: Results from the real-life G-EPOSS... von Gerdes, Sascha, Zimmer, Sebastian, Schwinn, Andreas, Ostendorf, Rolf, Jacobsen, Simmy, Makuc, Judita, Trenkler, Nina, Behrens, Juliane, Tabori, Sarah, Mortazawi, Dariusch

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50236 GUIDE trial results after withdrawal in part 3: Long-term remission in patients with psoriasis treated with guselkumab within 15 months from onset of symptoms von Schäkel, Knut, Asadullah, Khusru, Pinter, Andreas, Weisenseel, Peter, Sabat, Robert, Hoffmann, Matthias, Paul, Carle, Taut, Friedemann, Spindler, Nikolas, Tabori, Sarah, Eyerich, Kilian

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49730 GUIDE trial (part 3): Following guselkumab withdrawal and a long treatment-free period, disease control is rapidly regained upon re-treatment in psoriasis super-responders von Asadullah, Khusru, Schäkel, Knut, Pinter, Andreas, Weisenseel, Peter, Paul, Carle, Wegner, Sven, Taut, Friedemann, Makuc, Judita, Spindler, Nikolas, Tabori, Sarah, Eyerich, Kilian

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Noninferiority of 16-Week vs 8-Week Guselkumab Dosing in Super Responders for Maintaining Control of Psoriasis: The GUIDE Randomized Clinical Trial von Eyerich, Kilian, Asadullah, Khusru, Pinter, Andreas, Weisenseel, Peter, Reich, Kristian, Paul, Carle, Sabat, Robert, Wolk, Kerstin, Eyerich, Stefanie, Lauffer, Felix, Angsana, Julianty, Taut, Friedemann J. H, Kohler, Kristen, Chen, Yanqing, Sendecki, Jocelyn, Leung, Monica W. L, Wegner, Sven, Personke, Yvonne, Gomez, Mario, Krüger, Nenja, Tabori, Sarah, Schäkel, Knut

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A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01 von Perreault, Sébastien, Larouche, Valérie, Tabori, Uri, Hawkin, Cynthia, Lippé, Sarah, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, Sultan, Serge, Cantin, Édith, Routhier, Marie-Ève, Caru, Maxime, Legault, Geneviève, Bouffet, Éric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Jabado, Nada

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Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood von Achatz, Maria Isabel, Porter, Christopher C, Brugières, Laurence, Druker, Harriet, Frebourg, Thierry, Foulkes, William D, Kratz, Christian P, Kuiper, Roland P, Hansford, Jordan R, Hernandez, Hector Salvador, Nathanson, Katherine L, Kohlmann, Wendy K, Doros, Leslie, Onel, Kenan, Schneider, Kami Wolfe, Scollon, Sarah R, Tabori, Uri, Tomlinson, Gail E, Evans, D Gareth R, Plon, Sharon E

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TP53 Alterations Determine Clinical Subgroups and Survival of Patients With Choroid Plexus Tumors von Tabori, Uri, Shlien, Adam, Baskin, Berivan, Levitt, Sarah, Ray, Peter, Alon, Noa, Hawkins, Cynthia, Bouffet, Eric, Pienkowska, Malgorzata, Lafay-Cousin, Lucie, Gozali, Alexa, Zhukova, Nataliya, Shane, Lisa, Gonzalez, Ignacio, Finlay, Jonathan, Malkin, David

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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers von Shlien, Adam, Campbell, Brittany B, de Borja, Richard, Alexandrov, Ludmil B, Merico, Daniele, Wedge, David, Van Loo, Peter, Tarpey, Patrick S, Coupland, Paul, Behjati, Sam, Pollett, Aaron, Lipman, Tatiana, Heidari, Abolfazl, Deshmukh, Shriya, Avitzur, Na'ama, Meier, Bettina, Gerstung, Moritz, Hong, Ye, Merino, Diana M, Ramakrishna, Manasa, Remke, Marc, Arnold, Roland, Panigrahi, Gagan B, Thakkar, Neha P, Hodel, Karl P, Henninger, Erin E, Göksenin, A Yasemin, Bakry, Doua, Charames, George S, Druker, Harriet, Lerner-Ellis, Jordan, Mistry, Matthew, Dvir, Rina, Grant, Ronald, Elhasid, Ronit, Farah, Roula, Taylor, Glenn P, Nathan, Paul C, Alexander, Sarah, Ben-Shachar, Shay, Ling, Simon C, Gallinger, Steven, Constantini, Shlomi, Dirks, Peter, Huang, Annie, Scherer, Stephen W, Grundy, Richard G, Durno, Carol, Aronson, Melyssa, Gartner, Anton, Meyn, M Stephen, Taylor, Michael D, Pursell, Zachary F, Pearson, Christopher E, Malkin, David, Futreal, P Andrew, Stratton, Michael R, Bouffet, Eric, Hawkins, Cynthia, Campbell, Peter J, Tabori, Uri

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Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline von Lim-Fat, Mary Jane, Macdonald, Maria, Lapointe, Sarah, Climans, Seth Andrew, Cacciotti, Chantel, Chahal, Manik, Perreault, Sebastien, Tsang, Derek S., Gao, Andrew, Yip, Stephen, Keith, Julia, Bennett, Julie, Ramaswamy, Vijay, Detsky, Jay, Tabori, Uri, Das, Sunit, Hawkins, Cynthia

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Canadian Consensus for Treatment of BRAF V600E Mutated Pediatric and AYA Gliomas von Erker, Craig, Vanan, Magimairajan Issai, Larouche, Valérie, Nobre, Liana, Cacciotti, Chantel, Vairy, Stéphanie, Zelcer, Shayna, Fleming, Adam, Bouffet, Eric, Jabado, Nada, Legault, Geneviève, Renzi, Samuele, McKeown, Tara, Crooks, Bruce, Thacker, Nirav, Ramaswamy, Vijay, Coltin, Hallie, Lafay-Cousin, Lucie, Cheng, Sylvia, Hukin, Juliette, Climans, Seth Andrew, Lim-Fat, Mary Jane, McKillop, Sarah, Lapointe, Sarah, Alves, Mélanie, Bennett, Julie, Tabori, Uri, Perreault, Sébastien

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INNV-35. IMPLEMENTATION OF A NATIONAL ADOLESCENT AND YOUNG ADULT MOLECULAR TUMOR BOARD: REPORT FROM THE CANADIAN AYA NEURO-ONCOLOGY NETWORK von Lim-Fat, Mary-Jane, Das, Sunit, Climans, Seth, MacDonald, Maria, Perreault, Sébastien, Yip, Stephen, Harrison, Rebecca, Lapointe, Sarah, Chan, Aimee, Massey, Natalie, Erker, Craig, MacNeil, Mary, Ironside, Sarah, Tsang, Derek, Hawkins, Cynthia, Tabori, Uri, Bennett, Julie

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Diagnostic classification of childhood cancer using multiscale transcriptomics von Comitani, Federico, Nash, Joshua O., Cohen-Gogo, Sarah, Chang, Astra I., Wen, Timmy T., Maheshwari, Anant, Goyal, Bipasha, Tio, Earvin S., Tabatabaei, Kevin, Mayoh, Chelsea, Zhao, Regis, Ho, Ben, Brunga, Ledia, Lawrence, John E. G., Balogh, Petra, Flanagan, Adrienne M., Teichmann, Sarah, Huang, Annie, Ramaswamy, Vijay, Hitzler, Johann, Wasserman, Jonathan D., Gladdy, Rebecca A., Dickson, Brendan C., Tabori, Uri, Cowley, Mark J., Behjati, Sam, Malkin, David, Villani, Anita, Irwin, Meredith S., Shlien, Adam

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Clinical outcomes and patient-matched molecular composition of relapsed medulloblastoma von Kumar, Rahul, Smith, Kyle S., Deng, Maximilian, Terhune, Colt, Robinson, Giles W, Orr, Brent A., Liu, Anthony P. Y., Lin, Tong, Billups, Catherine A., Chintagumpala, Murali, Bowers, Daniel C., Hassall, Timothy E., Hansford, Jordan R., Khuong-Quang, Dong Anh, Crawford, John R., Bendel, Anne E., Gururangan, Sridharan, Schroeder, Kristin, Bouffet, Eric, Bartels, Ute, Fisher, Michael J., Cohn, Richard, Partap, Sonia, Kellie, Stewart J., McCowage, Geoffrey, Paulino, Arnold C., Rutkowski, Stefan, Fleischhack, Gudrun, Dhall, Girish, Klesse, Laura J., Leary, Sarah, Nazarian, Javad, Kool, Marcel, Wesseling, Pieter, Ryzhova, Marina, Zheludkova, Olga, Golanov, Andrey V., McLendon, Roger E., Packer, Roger J., Dunham, Christopher, Hukin, Juliette, Fouladi, Maryam, Faria, Claudia, Pimentel, José, Walter, Andrew W., Jabado, Nada, Cho, Yoon-Jae, Perreault, Sebastien, Croul, Sidney E., Zapotocky, Michal, Hawkins, Cynthia, Tabori, Uri, Taylor, Michael D., Pfister, Stefan M., Klimo, Paul, Boop, Frederick A., Ellison, David W., Merchant, Thomas E., Onar-Thomas, Arzu, Korshunov, Andrey, Jones, David T. W., Gajjar, Amar, Ramaswamy, Vijay, Northcott, Paul A.

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Heterogeneity within the PF-EPN-B ependymoma subgroup von Cavalli, Florence M. G., Hübner, Jens-Martin, Sharma, Tanvi, Luu, Betty, Sill, Martin, Zapotocky, Michal, Mack, Stephen C., Witt, Hendrik, Lin, Tong, Shih, David J. H., Ho, Ben, Santi, Mariarita, Emery, Lyndsey, Hukin, Juliette, Dunham, Christopher, McLendon, Roger E., Lipp, Eric S., Gururangan, Sridharan, Grossbach, Andrew, French, Pim, Kros, Johan M., van Veelen, Marie-Lise C., Rao, Amulya A. Nageswara, Giannini, Caterina, Leary, Sarah, Jung, Shin, Faria, Claudia C., Mora, Jaume, Schüller, Ulrich, Alonso, Marta M., Chan, Jennifer A., Klekner, Almos, Chambless, Lola B., Hwang, Eugene I., Massimino, Maura, Eberhart, Charles G., Karajannis, Matthias A., Lu, Benjamin, Liau, Linda M., Zollo, Massimo, Ferrucci, Veronica, Carlotti, Carlos, Tirapelli, Daniela P. C., Tabori, Uri, Bouffet, Eric, Ryzhova, Marina, Ellison, David W., Merchant, Thomas E., Gilbert, Mark R., Armstrong, Terri S., Korshunov, Andrey, Pfister, Stefan M., Taylor, Michael D., Aldape, Kenneth, Pajtler, Kristian W., Kool, Marcel, Ramaswamy, Vijay

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INNV-26. THE CHALLENGE OF TREATING ADULTS WITH MEDULLOBLASTOMA – THE CANON EXPERIENCE von Bennett, Julie, Lim-Fat, Mary-Jane, Roberto, Katrina, Massey, Natalie, Ramaswamy, Vijay, Sahgal, Arjun, Mason, Warren, Morgan, Erin, Ironside, Sarah, Ahmed, Osama, Tsang, Derek, Das, Sunit, Tabori, Uri, Hawkins, Cynthia, Climans, Seth

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INNV-10. GLIOMAS IN ADOLESCENTS AND YOUNG ADULTS – EXPERIENCE OF CASES PRESENTED AT NATIONAL AYA MULTI-DISCIPLINARY ROUNDS von Bennett, Julie, Massey, Natalie, Das, Sunit, Climans, Seth, MacDonald, Maria, Perreault, Sébastien, Vanan, Magimairajan Issai, Yip, Stephen, Lapointe, Sarah, Tsang, Derek, Tabori, Uri, Hawkins, Cynthia, Lim-Fat, Mary-Jane

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Impact of trametinib on the neuropsychological profile of NF1 patients von Lalancette, Eve, Cantin, Édith, Routhier, Marie-Ève, Mailloux, Chantal, Bertrand, Marie-Claude, Kiaei, Dorsa Sadat, Larouche, Valérie, Tabori, Uri, Hawkins, Cynthia, Ellezam, Benjamin, Décarie, Jean-Claude, Théoret, Yves, Métras, Marie-Élaine, McKeown, Tara, Ospina, Luis H., Vairy, Stéphanie, Ramaswamy, Vijay, Coltin, Hallie, Sultan, Serge, Legault, Geneviève, Bouffet, Éric, Lafay-Cousin, Lucie, Hukin, Juliette, Erker, Craig, Caru, Maxime, Dehaes, Mathieu, Jabado, Nada, Perreault, Sébastien, Lippé, Sarah

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