Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations von Tyhonas, John S., Arnold, Lee D., Cox, Jason M., Franovic, Aleksandra, Gardiner, Elisabeth, Grandinetti, Kathryn, Kania, Robert, Kanouni, Toufike, Lardy, Matthew, Li, Chun, Martin, Eric S., Miller, Nichol, Mohan, Adithi, Murphy, Eric A., Perez, Michelle, Soroceanu, Liliana, Timple, Noel, Uryu, Sean, Womble, Scott, Kaldor, Stephen W.

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition von Chen, Young K., Kanouni, Toufike, Arnold, Lee D., Cox, Jason M., Gardiner, Elisabeth, Grandinetti, Kathryn, Jiang, Ping, Kaldor, Stephen W., Lee, Catherine, Li, Chun, Martin, Eric S., Miller, Nichol, Murphy, Eric A., Timple, Noel, Tyhonas, John S., Vassar, Angie, Wang, Tim S., Williams, Richard, Yuan, Ding, Kania, Robert S.

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A tailored therapy for the metabolic syndrome: The dual peroxisome proliferator-activated receptor-α/γ agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia wh... von ETGEN, Garret J, OLDHAM, Brian A, SHUKER, Anthony J, RITO, Christopher J, MCCARTHY, James R, ARDECKY, Robert J, TYHONAS, John S, DANA, Sharon L, BILAKOVICS, James M, PATERNITI, James R, OGILVIE, Kathleen M, SHA LIU, JOHNSON, William T, KAUFFMAN, Raymond F, BRODERICK, Carol L, MONTROSE, Chahrzad R, BROZINICK, Joseph T, MISENER, Elizabeth A, BEAN, James S, BENSCH, William R, BROOKS, Dawn A

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Activity of KIN-3248, a next-generation pan-FGFR inhibitor, against acquired FGFR-gatekeeper and molecular-brake drug resistance mutations von Franovic, Aleksandra, Mohan, Adithi, Uryu, Sean, Wu, Qibiao, Jiang, Ping, Miller, Nichol, Tyhonas, John, Timple, Noelito, Severson, Paul, Kania, Robert, Murphy, Eric, Bardeesy, Nabeel, Martin, Eric

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids von Michellys, Pierre-Yves, Ardecky, Robert J, Chen, Jyun-Hung, D'Arrigo, Jennifer, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Montrose-Rafizadeh, Chahrzad, Ogilvie, Katheen M, Reifel-Miller, Anne, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Boehm, Marcus F

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Investigation of a Synthesis of meso-Porphyrins Employing High Concentration Conditions and an Electron Transport Chain for Aerobic Oxidation von Lindsey, Jonathan S, MacCrum, Kristy A, Tyhonas, John S, Chuang, Yao Yuan

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5 (Z) -Benzylidene -1,2 -dihydro -9 -hydroxy -10 -methoxy -2,2, 4 -trimethyl -5H-1 -aza -6 -oxa -chrysenes as non-steroidal glucocorticoid receptor modulators von ARDECKY, Robert J, HUDSON, Andrew R, LOPEZ, Francisco J, MARSCHKE, Keith B, MINER, Jeffrey N, KARANEWSKY, Donald S, NEGRO-VILAR, Andrés, LIN ZHI, PHILLIPS, Dean P, TYHONAS, John S, DECKHUT, Charlotte, LAU, Thomas L, YONGKAI LI, MARTINBOROUGH, Esther A, ROACH, Steven L, HIGUCHI, Robert I

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Beneficial effects of salts on an acid-catalyzed condensation leading to porphyrin formation von Li, Feirong, Kexin Yang, Tyhonas, John S., MacCrum, Kristy A., Lindsey, Jonathan S.

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Design and synthesis of novel RXR-selective modulators with improved pharmacological profile von Michellys, Pierre-Yves, Boehm, Marcus F, Chen, Jyun-Hung, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Reifel-Miller, Anne, Ogilvie, Katheen M, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Yumibe, Nathan, Ardecky, Robert J

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Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure von Lanier, Marion, Pickens, Jason, Bigi, Simone V, Bradshaw-Pierce, Erica L, Chambers, Alison, Cheruvallath, Zacharia S, Cole, Derek, Dougan, Douglas R, Ermolieff, Jacques, Gibson, Tony, Halkowycz, Petro, Hirokawa, Aki, Ivetac, Anthony, Miura, Joanne, Nunez, Evan, Sabat, Mark, Tyhonas, John, Wang, Haixia, Wang, Xiaolun, Swann, Steve

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Correction to “Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure” von Lanier, Marion, Pickens, Jason, Bigi, Simone V, Bradshaw-Pierce, Erica L, Chambers, Alison, Cheruvallath, Zacharia S, Cole, Derek, Dougan, Douglas R, Ermolieff, Jacques, Gibson, Tony, Halkowycz, Petro, Hirokawa, Aki, Ivetac, Anthony, McBride, Christopher, Miura, Joanne, Nunez, Evan, Sabat, Mark, Tyhonas, John, Wang, Haixia, Wang, Xiaolun, Swann, Steve

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INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES von KALDOR, Stephen, W, TYHONAS, John

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INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES von TYHONAS, John, KALDOR, Stephen W

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Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids:  A New Class of Dual PPARα/γ Agonists von Brooks, Dawn A, Etgen, Garret J, Rito, Christopher J, Shuker, Anthony J, Dominianni, Samuel J, Warshawsky, Alan M, Ardecky, Robert, Paterniti, James R, Tyhonas, John, Karanewsky, Donald S, Kauffman, Raymond F, Broderick, Carol L, Oldham, Brian A, Montrose-Rafizadeh, Chahzrad, Winneroski, Leonard L, Faul, Margaret M, McCarthy, James R

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INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES von KALDOR, Stephen, W, TYHONAS, John

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Inhibitors of fibroblast growth factor receptor kinases von TYHONAS, John, KALDOR, Stephen W

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Inhibitors of raf kinases von Kanouni, Toufike, Tyhonas, John, Kaldor, Stephen W, Murphy, Eric A

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INHIBITORS OF RAF KINASES von MURPHY, Eric A, TYHONAS, John, KALDOR, Stephen W, KANOUNI, Toufike

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A Tailored Therapy for the Metabolic Syndrome von Etgen, Garret J., Oldham, Brian A., Johnson, William T., Broderick, Carol L., Montrose, Chahrzad R., Brozinick, Joseph T., Misener, Elizabeth A., Bean, James S., Bensch, William R., Brooks, Dawn A., Shuker, Anthony J., Rito, Christopher J., McCarthy, James R., Ardecky, Robert J., Tyhonas, John S., Dana, Sharon L., Bilakovics, James M., Paterniti, James R., Ogilvie, Kathleen M., Liu, Sha, Kauffman, Raymond F.

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INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR KINASES von KALDOR, STEPHEN W, TYHONAS, JOHN

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