The medicinal chemist's toolbox for late stage functionalization of drug-like molecules von Cernak, Tim, Dykstra, Kevin D, Tyagarajan, Sriram, Vachal, Petr, Krska, Shane W

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Enhancing Efficiency of Natural Product Structure Revision: Leveraging CASE and DFT over Total Synthesis von Elyashberg, Mikhail, Tyagarajan, Sriram, Mandal, Mihir, Buevich, Alexei V

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Synthesis of pyrimidines from ketones using microwave irradiation von Tyagarajan, Sriram, Chakravarty, Prasun K.

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An orally available non-nucleotide STING agonist with antitumor activity von Pan, Bo-Sheng, Perera, Samanthi A, Piesvaux, Jennifer A, Presland, Jeremy P, Schroeder, Gottfried K, Cumming, Jared N, Trotter, B Wesley, Altman, Michael D, Buevich, Alexei V, Cash, Brandon, Cemerski, Saso, Chang, Wonsuk, Chen, Yiping, Dandliker, Peter J, Feng, Guo, Haidle, Andrew, Henderson, Timothy, Jewell, James, Kariv, Ilona, Knemeyer, Ian, Kopinja, Johnny, Lacey, Brian M, Laskey, Jason, Lesburg, Charles A, Liang, Rui, Long, Brian J, Lu, Min, Ma, Yanhong, Minnihan, Ellen C, O'Donnell, Greg, Otte, Ryan, Price, Laura, Rakhilina, Larissa, Sauvagnat, Berengere, Sharma, Sharad, Tyagarajan, Sriram, Woo, Hyun, Wyss, Daniel F, Xu, Serena, Bennett, David Jonathan, Addona, George H

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Electrochemical bromination of late stage intermediates and drug molecules von Tan, Zheng, Liu, Yong, Helmy, Roy, Rivera, Nelo R., Hesk, David, Tyagarajan, Sriram, Yang, Lu, Su, Jing

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Bismuth Acetate as a Catalyst for the Sequential Protodeboronation of Di- and Triborylated Indoles von Shen, Fangyi, Tyagarajan, Sriram, Perera, Damith, Krska, Shane W, Maligres, Peter E, Smith, Milton R, Maleczka, Robert E

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Fragment-based screening approach reveals non-orthosteric pockets in the search for allosteric inhibitors of tau-tubulin kinase 1 von Hayes, Robert P., DiNunzio, Edward, Yazdani, Mahdieh, Sikorska, Justyna, Chen, Yili, Tyagarajan, Sriram, Park, Younghee, Lee, Amy, Reyes, Cesar, Burschowsky, Daniel, Zebisch, Matthias, Ou, Yangsi, Bukhtiyarova, Marina, Niroomand, Shahriar, Tian, Yuan, Stachel, Shawn, Su, Hua, Hicks, Jacqueline D., Wyss, Daniel F.

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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties von Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G

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Enabling Efficient Late‐Stage Functionalization of Drug‐Like Molecules with LC‐MS and Reaction‐Driven Data Processing von Yao, Huifang, Liu, Yong, Tyagarajan, Sriram, Streckfuss, Eric, Reibarkh, Mikhail, Chen, Kuanchang, Zamora, Ismael, Fontaine, Fabien, Goracci, Laura, Helmy, Roy, Bateman, Kevin P., Krska, Shane W.

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Correction: The medicinal chemist's toolbox for late stage functionalization of drug-like molecules von Cernak, Tim, Dykstra, Kevin D, Tyagarajan, Sriram, Vachal, Petr, Krska, Shane W

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Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes von Liu, Jian, Guiadeen, Deodial, Krikorian, Arto, Gao, Xiaolei, Wang, James, Babu Boga, Sobhana, Alhassan, Abdul-Basit, Yu, Wensheng, Selyutin, Oleg, Yu, Younong, Anand, Rajan, Xu, Jiayi, Kelly, Joseph, Duffy, Joseph L., Liu, Shilan, Yang, Chundao, Wu, Hao, Cai, Jiaqiang, Bennett, Chad, Maloney, Kevin M., Tyagarajan, Sriram, Gao, Ying-Duo, Fischmann, Thierry O., Presland, Jeremy, Mansueto, My, Xu, Zangwei, Leccese, Erica, Zhang-Hoover, Jie, Knemeyer, Ian, Garlisi, Charles G., Stivers, Peter, Brandish, Philip E., Hicks, Alexandra, Kim, Ronald, Kozlowski, Joseph A.

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Rapid Affinity and Microsomal Stability Ranking of Crude Mixture Libraries of Histone Deacetylase Inhibitors von Tyagarajan, Sriram, Andrews, Christine L., Beshore, Douglas C., Buevich, Alexei V., Curran, Patrick J., Dandliker, Peter, Greshock, Thomas J., Hoar, Jason, Kim, Alex, Karnachi, Prabha, Knemeyer, Ian, Kozlowski, Joseph, Liu, Jian, Maletic, Milana, Myers, Robert, Rada, Vanessa, Sha, Deyou, Sauvagnat, Berengere, Vachal, Petr, Wolkenberg, Scott, Yu, Wensheng, Yu, Younong, Krska, Shane W.

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Heterocyclic Regioisomer Enumeration (HREMS): A Cheminformatics Design Tool von Tyagarajan, Sriram, Lowden, Christopher T, Peng, Zhengwei, Dykstra, Kevin D, Sherer, Edward C, Krska, Shane W

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) von Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.

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Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain von Tyagarajan, Sriram, Chakravarty, Prasun K., Zhou, Bishan, Taylor, Brett, Eid, Ronsar, Fisher, Michael H., Parsons, William H., Wyvratt, Mathew J., Lyons, Kathryn A., Klatt, Tracy, Li, Xiaohua, Kumar, Sanjeev, Williams, Brande, Felix, John, Priest, Birgit T., Brochu, Richard M., Warren, Vivien, Smith, McHardy, Garcia, Maria, Kaczorowski, Gregory J., Martin, William J., Abbadie, Catherine, McGowan, Erin, Jochnowitz, Nina, Weber, Ann, Duffy, Joseph L.

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A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain von Tyagarajan, Sriram, Chakravarty, Prasun K, Park, Min, Zhou, Bishan, Herrington, James B, Ratliff, Kevin, Bugianesi, Randall M, Williams, Brande, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy, Garcia, Maria, Kaczorowski, Gregory J, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Madeira, Maria, Karanam, Bindhu, Green, Mitchell, Forrest, Michael J, Abbadie, Catherine, McGowan, Erin, Mistry, Shruti, Jochnowitz, Nina, Duffy, Joseph L

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Substituted biaryl pyrazoles as sodium channel blockers von Tyagarajan, Sriram, Chakravarty, Prasun K., Zhou, Bishan, Taylor, Brett, Fisher, Michael H., Wyvratt, Mathew J., Lyons, Kathy, Klatt, Tracy, Li, Xiaohua, Kumar, Sanjeev, Williams, Brande, Felix, John, Priest, Birgit T., Brochu, Richard M., Warren, Vivien, Smith, McHardy, Garcia, Maria, Kaczorowski, Gregory J., Martin, William J., Abbadie, Catherine, McGowan, Erin, Jochnowitz, Nina, Parsons, William H.

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A potent and selective indole N-type calcium channel (Ca v2.2) blocker for the treatment of pain von Tyagarajan, Sriram, Chakravarty, Prasun K., Park, Min, Zhou, Bishan, Herrington, James B., Ratliff, Kevin, Bugianesi, Randall M., Williams, Brande, Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy, Garcia, Maria, Kaczorowski, Gregory J., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Madeira, Maria, Karanam, Bindhu, Green, Mitchell, Forrest, Michael J., Abbadie, Catherine, McGowan, Erin, Mistry, Shruti, Jochnowitz, Nina, Duffy, Joseph L.

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Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers von Tyagarajan, Sriram, Chakravarty, Prasun K., Zhou, Bishan, Fisher, Michael H., Wyvratt, Mathew J., Lyons, Kathy, Klatt, Tracy, Li, Xiaohua, Kumar, Sanjeev, Williams, Brande, Felix, John, Priest, Birgit T., Brochu, Richard M., Warren, Vivien, Smith, McHardy, Garcia, Maria, Kaczorowski, Gregory J., Martin, William J., Abbadie, Catherine, McGowan, Erin, Jochnowitz, Nina, Parsons, William H.

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Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones von Nagarathnam, D, Miao, S W, Lagu, B, Chiu, G, Fang, J, Murali Dhar, T G, Zhang, J, Tyagarajan, S, Marzabadi, M R, Zhang, F, Wong, W C, Sun, W, Tian, D, Wetzel, J M, Forray, C, Chang, R S, Broten, T P, Ransom, R W, Schorn, T W, Chen, T B, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, C M

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