Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma von Bhatia, Shailender, Longino, Natalie V., Miller, Natalie J., Kulikauskas, Rima, Iyer, Jayasri G., Ibrani, Dafina, Blom, Astrid, Byrd, David R., Parvathaneni, Upendra, Twitty, Christopher G., Campbell, Jean S., Le, Mai H., Gargosky, Sharron, Pierce, Robert H., Heller, Richard, Daud, Adil I., Nghiem, Paul

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Tumor-Derived Autophagosome Vaccine: Induction of Cross-Protective Immune Responses against Short-lived Proteins through a p62-Dependent Mechanism von TWITTY, Christopher G, JENSEN, Shawn M, HU, Hong-Ming, FOX, Bernard A

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Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12 von Garris, Christopher S., Arlauckas, Sean P., Kohler, Rainer H., Trefny, Marcel P., Garren, Seth, Piot, Cécile, Engblom, Camilla, Pfirschke, Christina, Siwicki, Marie, Gungabeesoon, Jeremy, Freeman, Gordon J., Warren, Sarah E., Ong, SuFey, Browning, Erica, Twitty, Christopher G., Pierce, Robert H., Le, Mai H., Algazi, Alain P., Daud, Adil I., Pai, Sara I., Zippelius, Alfred, Weissleder, Ralph, Pittet, Mikael J.

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Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity von Lee, Jack Y., Nguyen, Bianca, Mukhopadhyay, Anandaroop, Han, Mia, Zhang, Jun, Gujar, Ravindra, Salazar, Jon, Hermiz, Reneta, Svenson, Lauren, Browning, Erica, Lyerly, H. Kim, Canton, David A., Fisher, Daniel, Daud, Adil, Algazi, Alain, Skitzki, Joseph, Twitty, Christopher G.

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Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma von Algazi, Alain P., Twitty, Christopher G., Tsai, Katy K., Le, Mai, Pierce, Robert, Browning, Erica, Hermiz, Reneta, Canton, David A., Bannavong, Donna, Oglesby, Arielle, Francisco, Murray, Fong, Lawrence, Pittet, Mikael J., Arlauckas, Sean P., Garris, Christopher, Levine, Lauren P., Bifulco, Carlos, Ballesteros-Merino, Carmen, Bhatia, Shailender, Gargosky, Sharron, Andtbacka, Robert H. I., Fox, Bernard A., Rosenblum, Michael D., Daud, Adil I.

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Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro von Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.

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Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types von Twitty, Chris G, Diago, Oscar R, Hogan, Daniel J, Burrascano, Cindy, Ibanez, Carlos E, Jolly, Douglas J, Ostertag, Derek

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Intratumoral Plasmid IL12 Expands CD8(+) T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti-PD-1 Therapy von Telli, Melinda L., Nagata, Hiroshi, Wapnir, Irene, Acharya, Chaitanya R., Zablotsky, Kaitlin, Fox, Bernard A., Bifulco, Carlo B., Jensen, Shawn M., Ballesteros-Merino, Carmen, Le, Mai Hope, Pierce, Robert H., Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Jaffe, Kim, Sell, Jendy, Foerter, Kellie Malloy, Canton, David A., Twitty, Christopher G., Osada, Takuya, Lyerly, H. Kim, Crosby, Erika J.

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Intratumoral Plasmid IL12 Electroporation Therapy in Patients with Advanced Melanoma Induces Systemic and Intratumoral T-cell Responses von Greaney, Samantha K., Algazi, Alain P., Tsai, Katy K., Takamura, Kathryn T., Chen, Lawrence, Twitty, Christopher G., Zhang, Li, Paciorek, Alan, Pierce, Robert H., Le, Mai H., Daud, Adil, Fong, Lawrence

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Prognostic Biomarkers for Melanoma Immunotherapy von Twitty, Christopher G., Huppert, Laura A., Daud, Adil I.

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Intratumoral Electroporation of Plasmid Encoded IL12 and Membrane-Anchored Anti-CD3 Increases Systemic Tumor Immunity von Han, Mia, Nguyen, Bianca, Lee, Jack Y, Browning, Erica, Zhang, Jun, Mukhopadhyay, Anandaroop, Gujar, Ravindra, Salazar, Jon, Hermiz, Reneta, Svenson, Lauren, Rolig, Annah S, Redmond, William L, Algazi, Alain P, Daud, Adil I, Canton, David A, Twitty, Christopher G

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Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12 von Garris, Christopher S., Arlauckas, Sean P., Kohler, Rainer H., Trefny, Marcel P., Garren, Seth, Piot, Cécile, Engblom, Camilla, Pfirschke, Christina, Siwicki, Marie, Gungabeesoon, Jeremy, Freeman, Gordon J., Warren, Sarah E., Ong, SuFey, Browning, Erica, Twitty, Christopher G., Pierce, Robert H., Le, Mai H., Algazi, Alain P., Daud, Adil I., Pai, Sara I., Zippelius, Alfred, Weissleder, Ralph, Pittet, Mikael J.

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Increased frequency of suppressive regulatory T cells and T cell-mediated antigen loss results in murine melanoma recurrence von Jensen, Shawn M, Twitty, Christopher G, Maston, Levi D, Antony, Paul A, Lim, May, Hu, Hong-Ming, Petrausch, Ulf, Restifo, Nicholas P, Fox, Bernard A

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Multiple vaccinations: friend or foe von Church, Sarah E, Jensen, Shawn M, Twitty, Christopher G, Bahjat, Keith, Hu, Hong-Ming, Urba, Walter J, Fox, Bernard A

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Evaluation of the long-term anti-Spike immune response following a novel coronavirus vaccine (CORVax): electroporation of SARS-CoV-2 Spike plasmid DNA plus IL12 plasmid DNA von Jensen, Shawn M, Afentoulis, Michael, Wegmann, Keith, Canton, David A, Twitty, Christopher G, Fox, Bernard A

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Abstract 1557: Intratumoral plasmid IL-12 enhanced the systemic anti-tumor effect of anti-PD-1 antibody in triple-negative breast cancer von Nagata, Hiroshi, Osada, Takuya, Crosby, Erika J., Canton, David A., Twitty, Chris G., Lyerly, H. Kim

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Abstract 3195: Intratumoral electroporation of plasmid IL-12 and CXCL9 with membrane-bound anti-CD3 elicits robust anti-tumor immunity von Han, Mia, Mukhopadhyay, Anandaroop, Nguyen, Bianca, Sakurada, Kurt, Lee, Jack, Canton, David A., Twitty, Christopher G.

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Abstract CT022: Intratumoral plasmid IL-12 and electroporation in pre-treated inoperable locally advanced or recurrent triple-negative breast cancer (TNBC) von Telli, Melinda L., Zablotsky, Kaitlin, Gargosky, Sharron E., Twitty, Christopher G., Wapnir, Irene L.

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Abstract P2-14-06: Durable responses with intratumoral electroporation of plasmid interleukin-12 plus pembrolizumab in patients with advanced triple-negative breast cancer: Cohort... von Telli, Melinda L., Wapnir, Irene, Devitt, Bianca, Cuff, Katharine, Soliman, Hatem, Vinayak, Shaveta, Canton, David A., Twitty, Christopher G., Xie, Sunny, Lu, Ying, Bannavong, Donna, O'Keeffe, Bridget, Aung, Sandra, Joshi, Rohit

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Abstract PS17-22: Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patient... von Crosby, Erika J, Nagata, Hiroshi, Telli, Melinda L, Acharya, Chaitanya R, Wapnir, Irene, Zablotsky, Kaitlin, Browning, Erica, Hermiz, Reneta, Svenson, Lauren, Bannavong, Donna, Malloy, Kellie, Canton, David A, Twitty, Chris G, Osada, Takuya, Lyerly, Herbert Kim

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