Crystal structure of HIV-1 protease in complex with VX-478, a potent and orally bioavailable inhibitor of the enzyme von Kim, E. E, Baker, C. T, Dwyer, M. D, Murcko, M. A, Rao, B. G, Tung, R. D, Navia, M. A

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Metabolism of Amprenavir in Liver Microsomes: Role of CYP3A4 Inhibition for Drug Interactions von Decker, Caroline J., Laitinen, Leena M., Bridson, Gary W., Raybuck, Scott A., Tung, Roger D., Chaturvedi, Pravin R.

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Novel inhibitors of HIV protease : Design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds von SPALTENSTEIN, A, ALMOND, M. R, BOCK, W. J, CLEARY, D. G, FURFINE, E. S, HAZEN, R. J, KAZMIERSKI, W. M, SALITURO, F. G, TUNG, R. D, WRIGHT, L. L

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Weak Binding of VX-478 to Human Plasma Proteins and Implications for Anti-Human Immunodeficiency Virus Therapy von Livingston, David J., Pazhanisamy, S., Porter, David J. T., Partaledis, Judith A., Tung, Roger D., Painter, George R.

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Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir von FURFINE, Eric S, BAKER, Christopher T, HALE, Michael R, REYNOLDS, David J, SALISBURY, Jo A, SEARLE, Andy D, STUDENBERG, Scott D, TODD, Dan, TUNG, Roger D, SPALTENSTEIN, Andrew

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Design and synthesis of novel conformationally restricted HIV protease inhibitors von Salituro, Francesco G., Baker, Christopher T., Court, John J., Deininger, David D., Kim, Eunice E., Li, Biquin, Novak, Perry M., Rao, Bhisetti G., Pazhanisamy, S., Porter, Margaret D., Schairer, Wayne C., Tung, Roger D.

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Bis(2-oxo-3-oxazolidinyl)phosphinic chloride (1) as a coupling reagent for N-alkyl amino acids von Tung, Roger D, Rich, Daniel H

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Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors von Baker, Christopher T., Salituro, Francesco G., Court, John J., Deininger, David D., Kim, Eunice E., Li, Biquin, Novak, Perry M., Rao, Bhisetti G., Pazhanisamy, S., Schairer, Wayne C., Tung, Roger D.

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Design, synthesis and structure of non-macrocyclic inhibitors of FKBP12, the major binding protein for the immunosuppressant FK506 von Armistead, D. M., Badia, M. C., Deininger, D. D., Duffy, J. P., Saunders, J. O., Tung, R. D., Thomson, J. A., DeCenzo, M. T., Futer, O., Livingston, D. J., Murcko, M. A., Yamashita, M. M., Navia, M. A.

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Preclinical Profile of VX-950, a Potent, Selective, and Orally Bioavailable Inhibitor of Hepatitis C Virus NS3-4A Serine Protease von PERNI, Robert B, ALMQUIST, Susan J, HEISER, Angela, KALKERI, Gururaj, KOLACZKOWSKI, Elaine, KAI LIN, LUONG, Yu-Ping, GOVINDA RAO, B, TAYLOR, William P, THOMSON, John A, TUNG, Roger D, YUNYI WEI, BYRN, Randal A, KWONG, Ann D, CHAO LIN, CHANDORKAR, Gurudatt, CHATURVEDI, Pravin R, COURTNEY, Lawrence F, DECKER, Caroline J, DINEHART, Kirk, GATES, Cynthia A, HARBESON, Scott L

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Development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product von Williams, Peter D, Bock, Mark G, Tung, Roger D, Garsky, Victor M, Perlow, Debra S, Erb, Jill M, Lundell, G. F, Gould, Norman P, Whitter, Willie L

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Cyclic hexapeptide oxytocin antagonists. Potency-, selectivity-, and solubility-enhancing modifications von Freidinger, Roger M, Williams, P. D, Tung, R. D, Bock, M. G, Pettibone, D. J, Clineschmidt, B. V, DiPardo, R. M, Erb, J. M, Garsky, V. M

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Immunosuppressive activity of [MeBm2t]1-, D-diaminobutyryl-8-, and D- diaminopropyl-8-cyclosporin analogues correlates with inhibition of calcineurin phosphatase activity von Nelson, PA, Akselband, Y, Kawamura, A, Su, M, Tung, RD, Rich, DH, Kishore, V, Rosborough, SL, DeCenzo, MT, Livingston, DJ

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Synthesis of D-lysine8-cyclosporine A. Further characterization of BOP-Cl in the 2-7 hexapeptide fragment synthesis von Colucci, William J, Tung, Roger D, Petri, John A, Rich, Daniel H

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Use of N-Fmoc amino acid chlorides and activated 2-(fluorenylmethoxy)-5(4H)-oxazolones in solid-phase peptide synthesis. Efficient syntheses of highly N-alkylated cyclic hexapeptid... von Perlow, Debra S, Erb, Jill M, Gould, Norman P, Tung, Roger D, Freidinger, Roger M, Williams, Peter D, Veber, Daniel F

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BOP-Cl mediated synthesis of the cyclosporine A 8-11 tetrapeptide fragment von Tung, Roger D, Dhaon, Madhup K, Rich, Daniel H

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Total synthesis of the unusual cyclosporine amino acid MeBMT von Tung, Roger D, Rich, Daniel H

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Relevance of Plasma Protein Binding to Antiviral Activity and Clinical Efficacy of Inhibitors of Human Immunodeficiency Virus Protease von Bilello, John A., Drusano, George L.

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Reply von Livingston, D. J., Pazhanisamy, S., Partaledis, J. A., Tung, R. D.

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Literature Review von Collard, C. David, MD, Tung, Steven R., MD

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