GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees von Lanford, Robert E, Guerra, Bernadette, Chavez, Deborah, Giavedoni, Luis, Hodara, Vida L, Brasky, Kathleen M, Fosdick, Abigail, Frey, Christian R, Zheng, Jim, Wolfgang, Grushenka, Halcomb, Randall L, Tumas, Daniel B

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Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B von Menne, Stephan, Tumas, Daniel B, Liu, Katherine H, Thampi, Linta, AlDeghaither, Dalal, Baldwin, Betty H, Bellezza, Christine A, Cote, Paul J, Zheng, Jim, Halcomb, Randall, Fosdick, Abigail, Fletcher, Simon P, Daffis, Stephane, Li, Li, Yue, Peng, Wolfgang, Grushenka H.I, Tennant, Bud C

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Pharmacokinetic and pharmacodynamic properties of GS-9620, a novel Toll-like receptor 7 agonist, demonstrate interferon-stimulated gene induction without detectable serum interfero... von Fosdick, Abigail, Zheng, Jim, Pflanz, Stefan, Frey, Christian R, Hesselgesser, Joseph, Halcomb, Randall L, Wolfgang, Grushenka, Tumas, Daniel B

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Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis von Roethle, Paul A, McFadden, Ryan M, Yang, Hong, Hrvatin, Paul, Hui, Hon, Graupe, Michael, Gallagher, Brian, Chao, Jessica, Hesselgesser, Joseph, Duatschek, Paul, Zheng, Jim, Lu, Bing, Tumas, Daniel B, Perry, Jason, Halcomb, Randall L

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Loss of TACI Causes Fatal Lymphoproliferation and Autoimmunity, Establishing TACI as an Inhibitory BLyS Receptor von Seshasayee, Dhaya, Valdez, Patricia, Yan, Minhong, Dixit, Vishva M, Tumas, Daniel, Grewal, Iqbal S

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Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist von LOPATIN, Uri, WOLFGANG, Grushenka, TUMAS, Daniel, FREY, Christian R, OHMSTEDE, Carol, HESSELGESSER, Joseph, KEARNEY, Brian, MOOREHEAD, Lisa, SUBRAMANIAN, G. Mani, MCHUTCHISON, John G

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GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma von Reiser, Hans, Wang, Jianying, Chong, Lee, Watkins, William J, Ray, Adrian S, Shibata, Riri, Birkus, Gabriel, Cihlar, Tomas, Wu, Sylvia, Li, Bei, Liu, Xiaohong, Henne, Ilana N, Wolfgang, Grushenka H I, Desai, Manoj, Rhodes, Gerald R, Fridland, Arnold, Lee, William A, Plunkett, William, Vail, David, Thamm, Douglas H, Jeraj, Robert, Tumas, Daniel B

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Activation and accumulation of B cells in TACI-deficient mice von Grewal, Iqbal S, Dixit, Vishva M, Yan, Minhong, Wang, Hua, Chan, Betty, Roose-Girma, Meron, Erickson, Sharon, Baker, Thad, Tumas, Daniel

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FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family von Holcomb, Ilona N., Kabakoff, Rhona C., Chan, Betty, Baker, Thad W., Gurney, Austin, Henzel, William, Nelson, Chris, Lowman, Henry B., Wright, Barbara D., Skelton, Nicholas J., Frantz, Gretchen D., Tumas, Daniel B., Peale, Jr, Franklin V., Shelton, David L., Hébert, Caroline C.

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Assessment of GS-9219 in a Pet Dog Model of Non-Hodgkin's Lymphoma von VAIL, David M, THAMM, Douglas H, JERAJ, Robert, VANDERHOEK, Matt, PLAZA, Susan, ANDERSON, Christie, WESSEL, Mackenzie A, REBATE, Cecilia, LAWRENCE, Jessica, TUMAS, Daniel B, REISER, Hans, RAY, Adrian S, WOLFGANG, Grushenka H. I, WATKINS, William J, BABUSIS, Darius, HENNE, Ilana N, HAWKINS, Michael J, KURZMAN, Ilene D

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GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma von Thamm, Douglas H, Vail, David M, Kurzman, Ilene D, Babusis, Darius, Ray, Adrian S, Sousa-Powers, Noel, Tumas, Daniel B

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GS-9219/VDC-1101--a prodrug of the acyclic nucleotide PMEG has antitumor activity in spontaneous canine multiple myeloma von Thamm, Douglas H, Vail, David M, Kurzman, Ilene D, Babusis, Darius, Ray, Adrian S, Sousa-Powers, Noel, Tumas, Daniel B

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Use of 3'-Deoxy-3'-[¹⁸F]fluorothymidine pet/CT for evaluating response to cytotoxic chemotherapy in dogs with non-HODGKIN'S lymphoma von Lawrence, J, Vanderhoek, M, Barbee, D, Jeraj, R, Tumas, D.B, Vail, D.M

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Vascular Endothelial-Junctional Adhesion Molecule (VE-JAM)/JAM 2 Interacts with T, NK, and Dendritic Cells Through JAM 3 von Liang, Tony W, Chiu, Henry H, Gurney, Austin, Sidle, Aiko, Tumas, Daniel B, Schow, Peter, Foster, Jessica, Klassen, Toni, Dennis, Kathryn, DeMarco, Richard A, Pham, Thinh, Frantz, Gretchen, Fong, Sherman

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Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219 von TSAI, Cheng-Yu, RAY, Adrian S, TUMAS, Daniel B, KEATING, Michael J, REISER, Hans, PLUNKETT, William

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Inhibitory effect of carboxylic acid group on hERG binding von Zhu, Bing-Yan, Jia, Zhaozhong J., Zhang, Penglie, Su, Ting, Huang, Wenrong, Goldman, Erick, Tumas, Daniel, Kadambi, Vic, Eddy, Priya, Sinha, Uma, Scarborough, Robert M., Song, Yonghong

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Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation von Liang, Tony W, DeMarco, Richard A, Mrsny, Randy J, Gurney, Austin, Gray, Alane, Hooley, Jeffery, Aaron, Holly L, Huang, Arthur, Klassen, Toni, Tumas, Daniel B, Fong, Sherman

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VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain von van Bruggen, Nicholas, Thibodeaux, Harold, Palmer, James T., Lee, Wyne P., Fu, Ling, Cairns, Belinda, Tumas, Daniel, Gerlai, Robert, Williams, Simon-Peter, Campagne, Menno van Lookeren, Ferrara, Napoleone

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Modulation of allergic inflammation in mice deficient in TNF receptors von Rudmann, Daniel G, Moore, Mark W, Tepper, Jeffery S, Aldrich, Melinda C, Pfeiffer, Juergen W, Hogenesch, Harm, Tumas, Daniel B

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Can Retinoic Acid Ameliorate the Physiologic and Morphologic Effects of Elastase Instillation in the Rat? von Tepper, Jeffrey, Pfeiffer, Juergen, Aldrich, Melinda, Tumas, Daniel, Kern, Jeffrey, Hoffman, Eric, McLennan, Geoffrey, Hyde, Dallas

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