Potent, selective, and orally active adenosine A2A receptor antagonists : Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1 ,5-c]pyrimidines von NEUSTADT, Bernard R, JINSONG HAO, FOSTER, Carolyn, ARIK, Leyla, LACHOWICZ, Jean, NG, Kwokei, FENG, Kung-I, LINDO, Neil, GREENLEE, William J, STAMFORD, Andrew W, TULSHIAN, Deen, ONGINI, Ennio, HUNTER, John, MONOPOLI, Angela, BERTORELLI, Rosalia

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Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical mod... von McLeod, Robbie L., Tulshian, Deen B., Bolser, Donald C., Varty, Geoffrey B., Baptista, Marco, Fernandez, Xiomara, Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Ho, Ginny D., Jia, Yanlin, Ng, Fay W., Korfmacher, Walter, Xu, Xiaoying, Veals, John, Smith-Torhan, April, Wainhaus, Samuel, Fawzi, Ahmad B., Austin, Theodore M., van Heek, Margaret, Hey, John A.

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Where Are the New Cough Treatments: A Debriefing of Recent Clinical Proof-of-Concept Trials with the NOP Agonist SCH 486757 von McLeod, Robbie L., Tulshian, Deen B., Sadeh, Jonathan

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6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists von KISELGOF, Eugenia, TULSHIAN, Deen B, ARIK, Leyla, HONGTAO ZHANG, FAWZI, Ahmad

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The discovery and synthesis of novel adenosine receptor (A 2A) antagonists von Matasi, Julius J., Caldwell, John P., Hao, Jinsong, Neustadt, Bernard, Arik, Leyla, Foster, Carolyn J., Lachowicz, Jean, Tulshian, Deen B.

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Synthesis and SAR development of novel P2X₇ receptor antagonists for the treatment of pain: Part 2 von Brumfield, Stephanie, Matasi, Julius J, Tulshian, Deen, Czarniecki, Michael, Greenlee, William, Garlisi, Charles, Qiu, Hongchen, Devito, Kristine, Chen, Shu-Cheng, Sun, Yongliang, Bertorelli, Rosalia, Ansell, Justin, Geiss, William, Le, Van-Duc, Martin, Gregory S, Vellekoop, Samuel A, Haber, James, Allard, Melissa L

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Discovery of Orally Active 3-Pyridinyl-tropane As a Potent Nociceptin Receptor Agonist for the Management of Cough von Yang, Shu-Wei, Ho, Ginny, Tulshian, Deen, Greenlee, William J, Anthes, John, Fernandez, Xiomara, McLeod, Robbie L, Hey, John A, Xu, Xiaoying

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Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands von Caldwell, John P., Matasi, Julius J., Zhang, Hongtao, Fawzi, Ahmad, Tulshian, Deen B.

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The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety von Ho, Ginny D., Anthes, John, Bercovici, Ana, Caldwell, John P., Cheng, Kuo-Chi, Cui, Xiaoming, Fawzi, Ahmad, Fernandez, Xiomara, Greenlee, William J., Hey, John, Korfmacher, Walter, Lu, Sherry X., McLeod, Robbie L., Ng, Fay, Torhan, April Smith, Tan, Zheng, Tulshian, Deen, Varty, Geoffrey B., Xu, Xiaoying, Zhang, Hongtao

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Synthesis and structure–activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2 von Caldwell, John P., Matasi, Julius J., Fernandez, Xiomara, McLeod, Robbie L., Zhang, Hongtao, Fawzi, Ahmad, Tulshian, Deen B.

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Nociceptin inhibits cough in the guinea‐pig by activation of ORL1 receptors von McLeod, Robbie L, Parra, Leonard E, Mutter, Jennifer C, Erickson, Christine H, Carey, Galen J, Tulshian, Deen B, Fawzi, Ahmad B, Smith‐Torhan, April, Egan, Robert W, Cuss, Francis M, Hey, John A

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Antitussive action of nociceptin in the cat von Bolser, Donald C, McLeod, Robbie L, Tulshian, Deen B, Hey, John A

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2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: highly potent, orally active, adenosine A2A antagonists. Part 1 von Matasi, Julius J, Caldwell, John P, Zhang, Hongtao, Fawzi, Ahmad, Cohen-Williams, Mary E, Varty, Geoffrey B, Tulshian, Deen B

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SCH-202676: An Allosteric Modulator of Both Agonist and Antagonist Binding to G Protein-Coupled Receptors von Fawzi, A B, Macdonald, D, Benbow, L L, Smith-Torhan, A, Zhang, H, Weig, B C, Ho, G, Tulshian, D, Linder, M E, Graziano, M P

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3H-[1,2,4] -Triazolo[5,1-i]purin -5 -amine derivatives as adenosine A2A antagonists von SILVERMAN, Lisa S, CALDWELL, John P, ONGINI, Ennio, GREENLEE, William J, KISELGOF, Eugenia, MATASI, Julius J, TULSHIAN, Deen B, ARIK, Leyla, FOSTER, Carolyn, BERTORELLI, Rosalia, MONOPOLI, Angela

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Effect of a Novel NOP Receptor Agonist (SCH 225288) on Guinea Pig Irritant-Evoked, Feline Mechanically Induced and Canine Infectious Tracheobronchitis Cough von McLeod, Robbie L., Tulshian, Deen B., Ho, Ginny D., Fernandez, Xiomara, Bolser, Donald C., Parra, Leonard E., Zimmer, Jennifer C., Erickson, Christine H., Fawzi, Ahmad B., Jayappa, Huchappa, Lehr, Craig, Erskine, Jason, Smith-Torhan, April, Zhang, Hongtao, Hey, John A.

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2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: the successful reduction of hERG activity. Part 2 von Matasi, Julius J, Caldwell, John P, Zhang, Hongtao, Fawzi, Ahmad, Higgins, Guy A, Cohen-Williams, Mary E, Varty, Geoffrey B, Tulshian, Deen B

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Antitussive Effect of Nociceptin/Orphanin FQ in Experimental Cough Models von McLeod, Robbie L., Bolser, Donald C., Jia, Yanlin, Parra, Leonard E., Mutter, Jennifer C., Wang, Xin, Tulshian, Deen B., Egan, Robert W., Hey, John A.

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Novel pharmacological targets and progression of new antitussive drugs von McLeod, Robbie L, Tulshian, Deen B, Hey, John A

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Antitussive Profile of the NOP Agonist Ro-64-6198 in the Guinea Pig von McLeod, Robbie L., Jia, Yanlin, Fernandez, Xiomara, Parra, Leonard E., Wang, Xin, Tulshian, Deen B., Kiselgof, Eugenia J., Tan, Zheng, Fawzi, Ahmad B., Smith-Torhan, April, Zhang, Hongtao, Hey, John A.

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