Host sphingolipid biosynthesis as a target for hepatitis C virus therapy von Sakamoto, Hiroshi, Okamoto, Koichi, Aoki, Masahiro, Kato, Hideyuki, Katsume, Asao, Ohta, Atsunori, Tsukuda, Takuo, Shimma, Nobuo, Aoki, Yuko, Arisawa, Mikio, Kohara, Michinori, Sudoh, Masayuki

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Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non‐small‐cell lung cancer von Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

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A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes von Katsume, Asao, Tokunaga, Yuko, Hirata, Yuichi, Munakata, Tsubasa, Saito, Makoto, Hayashi, Hitohisa, Okamoto, Koichi, Ohmori, Yusuke, Kusanagi, Isamu, Fujiwara, Shinya, Tsukuda, Takuo, Aoki, Yuko, Klumpp, Klaus, Tsukiyama–Kohara, Kyoko, El–Gohary, Ahmed, Sudoh, Masayuki, Kohara, Michinori

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An orally available, small-molecule interferon inhibits viral replication von Konishi, Hideyuki, Okamoto, Koichi, Ohmori, Yusuke, Yoshino, Hitoshi, Ohmori, Hiroshi, Ashihara, Motooki, Hirata, Yuichi, Ohta, Atsunori, Sakamoto, Hiroshi, Hada, Natsuko, Katsume, Asao, Kohara, Michinori, Morikawa, Kazumi, Tsukuda, Takuo, Shimma, Nobuo, Foster, Graham R., Alazawi, William, Aoki, Yuko, Arisawa, Mikio, Sudoh, Masayuki

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Modification of a dihydropyrrolopyrimidine phosphoinositide 3-kinase (PI3K) inhibitor to improve oral bioavailability von Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shinma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

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Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho s... von Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Yamamoto, Shun, Koyama, Kohei, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

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Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors von Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation von Kawada, Hatsuo, Ebiike, Hirosato, Tsukazaki, Masao, Nakamura, Mitsuaki, Morikami, Kenji, Yoshinari, Kiyoshi, Yoshida, Miyuki, Ogawa, Kotaro, Shimma, Nobuo, Tsukuda, Takuo, Ohwada, Jun

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Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure–activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that s... von Hada, Kihito, Suda, Atsushi, Asoh, Kohsuke, Tsukuda, Takuo, Hasegawa, Masami, Sato, Yasuko, Ogawa, Kotaro, Kuramoto, Shino, Aoki, Yuko, Shimma, Nobuo, Ishikawa, Tsutomu, Koyano, Hiroshi

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Enhanced antitumor activity of erlotinib in combination with the H sp90 inhibitor CH 5164840 against non‐small‐cell lung cancer von Ono, Naomi, Yamazaki, Toshikazu, Tsukaguchi, Toshiyuki, Fujii, Toshihiko, Sakata, Kiyoaki, Suda, Atsushi, Tsukuda, Takuo, Mio, Toshiyuki, Ishii, Nobuya, Kondoh, Osamu, Aoki, Yuko

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5 H -benzo[ b ]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Abstract 2524: Targeting microtubule-associated protein 4 with novel small molecule CH4938056 confers antitumor activity under quasi in vivo conditions and in xenograft models von Kondoh, Osamu, Saito, Hidemi, Nakanishi, Yoshito, Tsukaguchi, Toshiyuki, Nagano, Kohji, Inomata, Noriyuki, Sakata, Kiyoaki, Fujii, Toshihiko, Satoh, Yasuko, Hattori, Kazuo, Niizuma, Satoshi, Koyama, Kohei, Okada, Takehiro, Minoshima, Yukinori, Kawashima, Toshiyuki, Kitamura, Toshio, Tsukuda, Takuo, Nobuo, Shimma, Arisawa, Mikio, Ishii, Nobuya, Aoki, Yuko

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Modeling, synthesis and biological activity of novel antifungal agents (1) von Tsukuda, Takuo, Shiratori, Yasuhiko, Watanabe, Masami, Ontsuka, Hitomi, Hattori, Kazuo, Shirai, Michio, Shimma, Nobuo

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Host Targeting Anti-HCV Agents for the Treatment of Hepatitis C Virus Infection: Discovery NA255, and Development of Its Efficient Synthetic Method von KAWASAKI, Kenichi, SAKAMOTO, Hiroshi, SUDOH, Masayuki, AOKI, Masahiro, TSUKUDA, Takuo

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Synthesis of novel antifungal agents (2) von Tsukuda, Takuo, Watanabe, Masami, Ontsuka, Hitomi, Hattori, Kazuo, Shirai, Michio, Shimma, Nobuo

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Synthesis of cyclohexyl analogs of restricticin von Tsukuda, Takuo, Watanabe, Masami, Ontsuka, Hitomi, Fujimoto, Yasuko, Shimma, Nobuo

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Substituted nucleosides von MARTIN JOSEPH ARMSTRONG, DEVOS RENE ROBERT, NAJERA ISABEL, JIANG WEN-RONG, SHIMMA NOBUO, HOBBS CHRISTOPHER JOHN, MERRETT JOHN HERBERT, TSUKUDA TAKUO

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Compound having anti-HCV activity and process for producing the same von FUKUDA, HIROSHI, TSUKUDA, TAKUO, HAYASE, TADAKATSU, SUDOH, MASAYUKI, WATANABE, FUMIO, KOMIYAMA, SUSUMU, KAWASAKI, KENICHI, MURATA, TAKESHI, MASUBUCHI, MIYAKO

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4'-SUBSTITUTED NUCLEOSIDES FOR THE TREATMENT OF DISEASES MEDIATED BY THE HEPATITIS C VIRUS von DEVOS RENE, HOBBS CHRISTOPHER, MARTIN JOSEPH, NAJERA ISABEL, SHIMMA NOBIO, JIANG WEN-RONG, MERRETT JOHN, TSUKUDA TAKUO

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