An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells von Rohle, Dan, Popovici-Muller, Janeta, Palaskas, Nicolaos, Turcan, Sevin, Grommes, Christian, Campos, Carl, Tsoi, Jennifer, Clark, Owen, Oldrini, Barbara, Komisopoulou, Evangelia, Kunii, Kaiko, Pedraza, Alicia, Schalm, Stefanie, Silverman, Lee, Miller, Alexandra, Wang, Fang, Yang, Hua, Chen, Yue, Kernytsky, Andrew, Rosenblum, Marc K., Liu, Wei, Biller, Scott A., Su, Shinsan M., Brennan, Cameron W., Chan, Timothy A., Graeber, Thomas G., Yen, Katharine E., Mellinghoff, Ingo K.

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Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma von Müller, Judith, Krijgsman, Oscar, Tsoi, Jennifer, Robert, Lidia, Hugo, Willy, Song, Chunying, Kong, Xiangju, Possik, Patricia A., Cornelissen-Steijger, Paulien D. M., Foppen, Marnix H Geukes, Kemper, Kristel, Goding, Colin R., McDermott, Ultan, Blank, Christian, Haanen, John, Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Peeper, Daniel S.

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Immunotherapy Resistance by Inflammation-Induced Dedifferentiation von Mehta, Arnav, Kim, Yeon Joo, Robert, Lidia, Tsoi, Jennifer, Comin-Anduix, Begoña, Berent-Maoz, Beata, Cochran, Alistair J, Economou, James S, Tumeh, Paul C, Puig-Saus, Cristina, Ribas, Antoni

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Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade von Torrejon, Davis Y, Abril-Rodriguez, Gabriel, Champhekar, Ameya S, Tsoi, Jennifer, Campbell, Katie M, Kalbasi, Anusha, Parisi, Giulia, Zaretsky, Jesse M, Garcia-Diaz, Angel, Puig-Saus, Cristina, Cheung-Lau, Gardenia, Wohlwender, Thomas, Krystofinski, Paige, Vega-Crespo, Agustin, Lee, Christopher M, Mascaro, Pau, Grasso, Catherine S, Berent-Maoz, Beata, Comin-Anduix, Begoña, Hu-Lieskovan, Siwen, Ribas, Antoni

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Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist von Parisi, Giulia, Saco, Justin D., Salazar, Felix B., Tsoi, Jennifer, Krystofinski, Paige, Puig-Saus, Cristina, Zhang, Ruixue, Zhou, Jing, Cheung-Lau, Gardenia C., Garcia, Alejandro J., Grasso, Catherine S., Tavaré, Richard, Hu-Lieskovan, Siwen, Mackay, Sean, Zalevsky, Jonathan, Bernatchez, Chantale, Diab, Adi, Wu, Anna M., Comin-Anduix, Begoña, Charych, Deborah, Ribas, Antoni

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MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species von Roider, Elisabeth, Lakatos, Alexandra I. T., McConnell, Alicia M., Wang, Poguang, Mueller, Alina, Kawakami, Akinori, Tsoi, Jennifer, Szabolcs, Botond L., Ascsillán, Anna A., Suita, Yusuke, Igras, Vivien, Lo, Jennifer A., Hsiao, Jennifer J., Lapides, Rebecca, Pál, Dorottya M. P., Lengyel, Anna S., Navarini, Alexander, Okazaki, Arimichi, Iliopoulos, Othon, Németh, István, Graeber, Thomas G., Zon, Leonard, Giese, Roger W., Kemeny, Lajos V., Fisher, David E.

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Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma von Wong, Deborah JL, Robert, Lidia, Atefi, Mohammad S, Lassen, Amanda, Avarappatt, Geetha, Cerniglia, Michael, Avramis, Earl, Tsoi, Jennifer, Foulad, David, Graeber, Thomas G, Comin-Anduix, Begonya, Samatar, Ahmed, Lo, Roger S, Ribas, Antoni

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High Interferon Signature Leads to Increased STAT1/3/5 Phosphorylation in PBMCs From SLE Patients by Single Cell Mass Cytometry von Yiu, Gloria, Rasmussen, Tue Kruse, Tsai, Brandon L, Diep, Vivian K, Haddon, David J, Tsoi, Jennifer, Miller, Gopika D, Comin-Anduix, Begoña, Deleuran, Bent, Crooks, Gay M, Utz, Paul J

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Interleukin 32 expression in human melanoma von Paz, Helicia, Tsoi, Jennifer, Kalbasi, Anusha, Grasso, Catherine S, McBride, William H, Schaue, Dörthe, Butterfield, Lisa H, Maurer, Deena M, Ribas, Antoni, Graeber, Thomas G, Economou, James S

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Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress von Tsoi, Jennifer, Robert, Lidia, Paraiso, Kim, Galvan, Carlos, Sheu, Katherine M., Lay, Johnson, Wong, Deborah J.L., Atefi, Mohammad, Shirazi, Roksana, Wang, Xiaoyan, Braas, Daniel, Grasso, Catherine S., Palaskas, Nicolaos, Ribas, Antoni, Graeber, Thomas G.

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Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma von Ribas, Antoni, Lawrence, Donald, Atkinson, Victoria, Agarwal, Sachin, Miller, Wilson H., Carlino, Matteo S., Fisher, Rosalie, Long, Georgina V., Hodi, F. Stephen, Tsoi, Jennifer, Grasso, Catherine S., Mookerjee, Bijoyesh, Zhao, Qing, Ghori, Razi, Moreno, Blanca Homet, Ibrahim, Nageatte, Hamid, Omid

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Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance von Su, Yapeng, Wei, Wei, Robert, Lidia, Xue, Min, Tsoi, Jennifer, Garcia-Diaz, Angel, Moreno, Blanca Homet, Kim, Jungwoo, Ng, Rachel H., Lee, Jihoon W., Koya, Richard C., Comin-Anduix, Begonya, Graeber, Thomas G., Ribas, Antoni, Heath, James R.

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Precise T cell recognition programs designed by transcriptionally linking multiple receptors von Williams, Jasper Z, Allen, Greg M, Shah, Devan, Sterin, Igal S, Kim, Ki H, Garcia, Vivian P, Shavey, Gavin E, Yu, Wei, Puig-Saus, Cristina, Tsoi, Jennifer, Ribas, Antoni, Roybal, Kole T, Lim, Wendell A

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Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma von Grasso, Catherine S., Tsoi, Jennifer, Onyshchenko, Mykola, Abril-Rodriguez, Gabriel, Ross-Macdonald, Petra, Wind-Rotolo, Megan, Champhekar, Ameya, Medina, Egmidio, Torrejon, Davis Y., Shin, Daniel Sanghoon, Tran, Phuong, Kim, Yeon Joo, Puig-Saus, Cristina, Campbell, Katie, Vega-Crespo, Agustin, Quist, Michael, Martignier, Christophe, Luke, Jason J., Wolchok, Jedd D., Johnson, Douglas B., Chmielowski, Bartosz, Hodi, F. Stephen, Bhatia, Shailender, Sharfman, William, Urba, Walter J., Slingluff, Craig L., Diab, Adi, Haanen, John B.A.G., Algarra, Salvador Martin, Pardoll, Drew M., Anagnostou, Valsamo, Topalian, Suzanne L., Velculescu, Victor E., Speiser, Daniel E., Kalbasi, Anusha, Ribas, Antoni

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CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire von ROBERT, Lidia, TSOI, Jennifer, KOYA, Richard C, GRAEBER, Thomas G, ROBINS, Harlan, RIBAS, Antoni, XIAOYAN WANG, EMERSON, Ryan, HOMET, Blanca, CHODON, Thinle, MOK, Stephen, RONG RONG HUANG, COCHRAN, Alistair J, COMIN-ANDUIX, Begoña

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Abstract 1905: In vivo CRISPR screen identifies tumor suppressors as drivers of tumor cell-intrinsic immune evasion von Min, Chengyin, Skoulidis, Ferdinandos, Zhou, Wenrong, Tsoi, Jennifer, Huang, Alan, Goldstein, Matthew J.

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Genetic Mechanisms of Immune Evasion in Colorectal Cancer von Grasso, Catherine S, Giannakis, Marios, Wells, Daniel K, Hamada, Tsuyoshi, Mu, Xinmeng Jasmine, Quist, Michael, Nowak, Jonathan A, Nishihara, Reiko, Qian, Zhi Rong, Inamura, Kentaro, Morikawa, Teppei, Nosho, Katsuhiko, Abril-Rodriguez, Gabriel, Connolly, Charles, Escuin-Ordinas, Helena, Geybels, Milan S, Grady, William M, Hsu, Li, Hu-Lieskovan, Siwen, Huyghe, Jeroen R, Kim, Yeon Joo, Krystofinski, Paige, Leiserson, Mark D M, Montoya, Dennis J, Nadel, Brian B, Pellegrini, Matteo, Pritchard, Colin C, Puig-Saus, Cristina, Quist, Elleanor H, Raphael, Ben J, Salipante, Stephen J, Shin, Daniel Sanghoon, Shinbrot, Eve, Shirts, Brian, Shukla, Sachet, Stanford, Janet L, Sun, Wei, Tsoi, Jennifer, Upfill-Brown, Alexander, Wheeler, David A, Wu, Catherine J, Yu, Ming, Zaidi, Syed H, Zaretsky, Jesse M, Gabriel, Stacey B, Lander, Eric S, Garraway, Levi A, Hudson, Thomas J, Fuchs, Charles S, Ribas, Antoni, Ogino, Shuji, Peters, Ulrike

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A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab von Nowicki, Theodore S, Berent-Maoz, Beata, Cheung-Lau, Gardenia, Huang, Rong Rong, Wang, Xiaoyan, Tsoi, Jennifer, Kaplan-Lefko, Paula, Cabrera, Paula, Tran, Justin, Pang, Jia, Macabali, Mignonette, Garcilazo, Ivan Perez, Carretero, Ignacio Baselga, Kalbasi, Anusha, Cochran, Alistair J, Grasso, Catherine S, Hu-Lieskovan, Siwen, Chmielowski, Bartosz, Comin-Anduix, Begoña, Singh, Arun, Ribas, Antoni

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Melanoma dedifferentiation induced by IFN-γ epigenetic remodeling in response to anti-PD-1 therapy von Kim, Yeon Joo, Sheu, Katherine M, Tsoi, Jennifer, Abril-Rodriguez, Gabriel, Medina, Egmidio, Grasso, Catherine S, Torrejon, Davis Y, Champhekar, Ameya S, Litchfield, Kevin, Swanton, Charles, Speiser, Daniel E, Scumpia, Philip O, Hoffmann, Alexander, Graeber, Thomas G, Puig-Saus, Cristina, Ribas, Antoni

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Abstract 553: Melanoma subtypes that emerge during adaptive resistance to therapy are targets for bispecific T cell engager (BiTE®) antibody constructs directed to CDH19 and DLL3 von Bailis, Julie M., Lee, Fei, Giffin, Michael, Hughes, Paul, Tsoi, Jennifer, Robert, Lidia, Graeber, Thomas G., Ribas, Antoni, Coxon, Angela

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