Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia von Yue, Zenglian, Pan, Chaohsuan, Wang, Siyuan, N. Tse, Archie, Sheng, Yucheng

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Comprehensive population pharmacokinetic modelling of sugemalimab, an anti-programmed death-ligand 1 (PD-L1) human monoclonal antibody, in patients with solid tumours or lymphomas... von Wang, Kun, Pan, Chaohsuan, Xu, Fengyan, Tse, Archie N, Sheng, Yucheng

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Predictive Gene Signatures Determine Tumor Sensitivity to MDM2 Inhibition von Ishizawa, Jo, Nakamaru, Kenji, Seki, Takahiko, Tazaki, Koichi, Kojima, Kensuke, Chachad, Dhruv, Zhao, Ran, Heese, Lauren, Ma, Wencai, Ma, Man Chun John, DiNardo, Courtney, Pierce, Sherry, Patel, Keyur P, Tse, Archie, Davis, R Eric, Rao, Arvind, Andreeff, Michael

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Targeting Checkpoint Kinase 1 in Cancer Therapeutics von TSE, Archie N, CARVAJAL, Richard, SCHWARTZ, Gary K

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Response Criteria for Intratumoral Immunotherapy in Solid Tumors: itRECIST von Goldmacher, Gregory V, Khilnani, Anuradha D, Andtbacka, Robert H I, Luke, Jason J, Hodi, F Stephen, Marabelle, Aurelien, Harrington, Kevin, Perrone, Andrea, Tse, Archie, Madoff, David C, Schwartz, Lawrence H

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies von Zabludoff, Sonya D, Deng, Chun, Grondine, Michael R, Sheehy, Adam M, Ashwell, Susan, Caleb, Benjamin L, Green, Stephen, Haye, Heather R, Horn, Candice L, Janetka, James W, Liu, Dongfang, Mouchet, Elizabeth, Ready, Shannon, Rosenthal, Judith L, Queva, Christophe, Schwartz, Gary K, Taylor, Karen J, Tse, Archie N, Walker, Graeme E, White, Anne M

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Aurora Kinases: New Targets for Cancer Therapy von CARVAJAL, Richard D, TSE, Archie, SCHWARTZ, Gary K

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Tumor growth inhibition‐overall survival modeling in non‐small cell lung cancer: A case study from GEMSTONE‐302 von Sheng, Yucheng, Teng, Shu‐wen, Wang, Jingru, Wang, Hao, Tse, Archie N.

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Dual CTLA‐4 and PD‐1 checkpoint blockade using CS1002 and CS1003 (nofazinlimab) in patients with advanced solid tumors: A first‐in‐human, dose‐escalation, and dose‐expansion study... von Bishnoi, Sarwan, Kotasek, Dusan, Aghmesheh, Morteza, Yau, Thomas, Cosman, Rasha, Prawira, Amy, Moore, Maggie, Chan, Stephen L., Mant, Andrew, Eek, Richard, Zielinski, Robert, Su, Rila, Pan, Zhaoxuan, Ma, Yiding, Li, Fei, Li, Peiqi, Tse, Archie N.

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A first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer von Day, Daphne, Park, John J., Coward, Jermaine, Markman, Ben, Lemech, Charlotte, Kuo, James C., Prawira, Amy, Brown, Michael P., Bishnoi, Sarwan, Kotasek, Dusan, Strother, R. Matthew, Cosman, Rasha, Su, Rila, Ma, Yiding, Yue, Zenglian, Hu, Hui-han, Wu, Rachel, Li, Peiqi, Tse, Archie N.

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Multicenter Phase II Study of Irinotecan, Cisplatin, and Bevacizumab in Patients With Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma von SHAH, Manish A, RAMANATHAN, Ramesh K, SCHWARTZ, Gary K, KELSEN, David P, ILSON, David H, LEVNOR, Alissa, D'ADAMO, David, O'REILLY, Eileen, TSE, Archie, TROCOLA, Robin, SCHWARTZ, Lawrence, CAPANU, Marinela

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Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry von KI YOUNG CHUNG, JINRU SHIA, KLIMSTRA, David S, FRIDMAN, Daniel, KELSEN, David P, SALTZ, Leonard B, KEMENY, Nancy E, SHAH, Manish, SCHWARTZ, Gary K, TSE, Archie, HAMILTON, Audrey, PAN, Dorothy, SCHRAG, Deborah, SCHWARTZ, Lawrence

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Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780 von Nair, Jayasree S, Ho, Alan L, Tse, Archie N, Coward, Jesse, Cheema, Haider, Ambrosini, Grazia, Keen, Nicholas, Schwartz, Gary K

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A Phase 1a/1b Dose Escalation/Expansion Study of the Anti-PD-1 Monoclonal Antibody Nofazinlimab in Chinese Patients with Solid Tumors or Lymphoma von Gong, Jifang, Guo, Ye, Zhang, Yanqiao, Ba, Yi, Chen, Tong, Li, Wei, Zhou, Caicun, Wang, Mengzhao, Yang, Haiyan, Zhou, Yuhong, Cai, Qiqing, Wang, Ziping, Huang, Gang, Zhang, Wei, Su, Rila, Cai, Zhongheng, Yue, Zenglian, Dou, Jinzhou, Li, Peiqi, Wu, Rachel, Tse, Archie N., Shen, Lin

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CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo von TSE, Archie N, RENDAHL, Katherine G, HIBNER, Barbara, GESNER, Thomas G, SCHWARTZ, Gary K, SHEIKH, Tahir, CHEEMA, Haider, AARDALEN, Kim, EMBRY, Millicent, MA, Sylvia, MOLER, Edward J, ZHI JIE NI, LOPES DE MENEZES, Daniel E

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A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors von TSE, Archie N, KLIMSTRA, David S, KI CHUNG, MAKI, Robert, LEFKOWITZ, Robert, BROWN, Karen, MANOVA-TODOROVA, Katia, NIAN WU, EGORIN, Merrill J, KELSEN, David, SCHWARTZ, Gary K, GONEN, Mithat, SHAH, Manish, SHEIKH, Tahir, SIKORSKI, Rachel, CARVAJAL, Richard, MUI, Janet, TIPIAN, Caroll, O'REILLY, Eileen

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Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase von McNeely, Samuel, Conti, Chiara, Sheikh, Tahir, Patel, Himali, Zabludoff, Sonya, Pommier, Yves G., Schwartz, Gary K., Tse, Archie

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Can a propensity score matching method be applied to assessing efficacy from single-arm proof-of-concept trials in oncology? von Teng, Shu-Wen, Su, Yu-Cheng, Pallantla, Ravikumar, Channavazzala, Madhav, Kumar, Rukmini, Sheng, Yucheng, Wang, Hao, Wang, Crystal, Tse, Archie

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Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer von Ciprotti, Marika, Tebbutt, Niall C, Lee, Fook-Thean, Lee, Sze-Ting, Gan, Hui K, McKee, David C, O'Keefe, Graeme J, Gong, Sylvia J, Chong, Geoffrey, Hopkins, Wendie, Chappell, Bridget, Scott, Fiona E, Brechbiel, Martin W, Tse, Archie N, Jansen, Mendel, Matsumura, Manabu, Kotsuma, Masakatsu, Watanabe, Rira, Venhaus, Ralph, Beckman, Robert A, Greenberg, Jonathan, Scott, Andrew M

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Potentiation of cytotoxicity of topoisomerase I poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either... von TSE, Archie N, SCHWARTZ, Gary K

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