Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose von Nawrat, Christopher C, Whittaker, Aaron M, Huffman, Mark A, McLaughlin, Mark, Cohen, Ryan D, Andreani, Teresa, Ding, Bangwei, Li, Hongming, Weisel, Mark, Tschaen, David M

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Highly Efficient Synthesis of HIV NNRTI Doravirine von Gauthier, Donald R, Sherry, Benjamin D, Cao, Yang, Journet, Michel, Humphrey, Guy, Itoh, Tetsuji, Mangion, Ian, Tschaen, David M

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A Mild Cu(I)-Catalyzed Oxidative Aromatization of Indolines to Indoles von Peng, Feng, McLaughlin, Mark, Liu, Yizhou, Mangion, Ian, Tschaen, David M, Xu, Yingju

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Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone von Patel, Niki R., Nawrat, Christopher C., McLaughlin, Mark, Xu, Yingju, Huffman, Mark A., Yang, Hao, Li, Hongming, Whittaker, Aaron M., Andreani, Teresa, Lévesque, François, Fryszkowska, Anna, Brunskill, Andrew, Tschaen, David M., Maloney, Kevin M.

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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction von Hyde, Alan M, Liu, Zhijian, Kosjek, Birgit, Tan, Lushi, Klapars, Artis, Ashley, Eric R, Zhong, Yong-Li, Alvizo, Oscar, Agard, Nicholas J, Liu, Guiquan, Gu, Xiuyan, Yasuda, Nobuyoshi, Limanto, John, Huffman, Mark A, Tschaen, David M

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Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction von Zhao, Matthew M, McNamara, James M, Ho, Guo-Jie, Emerson, Khateeta M, Song, Zhiguo J, Tschaen, David M, Brands, Karel M. J, Dolling, Ulf-H, Grabowski, Edward J. J, Reider, Paul J, Cottrell, Ian F, Ashwood, Michael S, Bishop, Brian C

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Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle von Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M

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Oxidation of Primary Alcohols to Carboxylic Acids with Sodium Chlorite Catalyzed by TEMPO and Bleach von Zhao, Mangzhu, Li, Jing, Mano, Eiichi, Song, Zhiguo, Tschaen, David M, Grabowski, Edward J. J, Reider, Paul J

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An Efficient Asymmetric Synthesis of an Estrogen Receptor Modulator by Sulfoxide-Directed Borane Reduction von Song, Zhiguo J., King, Anthony O., Waters, Marjorie S., Lang, Fengrui, Zewge, Daniel, Bio, Matthew, Leazer, Johnnie L., Javadi, Gary, Kassim, Amude, Tschaen, David M., Reamer, Robert A., Rosner, Thorsten, Chilenski, Jennifer R., Mathre, David J., Volante, R. P., Tillyer, Richard, Trost, Barry M.

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Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist von Song, Zhiguo J, Zhao, Mangzhu, Desmond, Richard, Devine, Paul, Tschaen, David M, Tillyer, Richard, Frey, Lisa, Heid, Richard, Xu, Feng, Foster, Bruce, Li, Jing, Reamer, Robert, Volante, Ralph, Dolling, Ulf H, Reider, Paul J, Okada, Shigemitsu, Kato, Yoshiaki, Mano, Eiichi

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Merck’s Reaction Review Policy: An Exercise in Process Safety von Bassan, Ephraim, Ruck, Rebecca T, Dienemann, Erik, Emerson, Khateeta M, Humphrey, Guy R, Raheem, Izzat T, Tschaen, David M, Vickery, Thomas P, Wood, Harold B, Yasuda, Nobuyoshi

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Highly Selective Cascade Couplings for the Syntheses of Functionalized Piperidinones and Bispidines von Xu, Feng, Corley, Edward, Murry, Jerry A, Tschaen, David M

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Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation von Song, Zhiguo J, Tellers, David M, Dormer, Peter G, Zewge, Daniel, Janey, Jacob M, Nolting, Andrew, Steinhuebel, Dietrich, Oliver, Steven, Devine, Paul N, Tschaen, David M

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Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist von Larsen, Robert D, King, Anthony O, Chen, Cheng Y, Corley, Edward G, Foster, Bruce S, Roberts, F. Edward, Yang, Chunhua, Lieberman, David R, Reamer, Robert A, Tschaen, David M, Verhoeven, Thomas R, Reider, Paul J, Lo, Young S, Rossano, Lucius T, Brookes, A. Sidney, Meloni, David, Moore, James R, Arnett, John F

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Practical Asymmetric Synthesis of a Selective Endothelin A Receptor (ETA) Antagonist von Song, Zhiguo J, Zhao, Matthew, Frey, Lisa, Li, Jing, Tan, Lushi, Chen, Cheng Y, Tschaen, David M, Tillyer, Richard, Grabowski, Edward J. J, Volante, Ralph, Reider, Paul J, Kato, Yoshiaki, Okada, Shigemitsu, Nemoto, Takayuki, Sato, Hiroki, Akao, Atsushi, Mase, Toshiaki

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Practical synthesis of a potent indolocarbazole-based, DNA topoisomerase inhibitor von Akao, Atsushi, Hiraga, Shouichi, Iida, Takehiko, Kamatani, Asayuki, Kawasaki, Masashi, Mase, Toshiaki, Nemoto, Takayuki, Satake, Nobuya, Weissman, Steven A, Tschaen, David M, Rossen, Kai, Petrillo, Daniel, Reamer, Robert A, Volante, R.P

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A novel chromium trioxide catalyzed oxidation of primary alcohols to the carboxylic acids von Zhao, Mangzhu, Li, Jing, Song, Zhiguo, Desmond, Richard, Tschaen, David M., Grabowski, Edward J.J., Reider, Paul J.

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Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle von Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M

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Practical Synthesis of a Potent Hepatitis C Virus RNA Replication Inhibitor von Bio, Matthew M, Xu, Feng, Waters, Marjorie, Williams, J. Michael, Savary, Kimberly A, Cowden, Cameron J, Yang, Chunhua, Buck, Elizabeth, Song, Zhiguo J, Tschaen, David M, Volante, R. P, Reamer, Robert A, Grabowski, Edward J. J

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Preparative Chromatography with Extreme Productivity: HPLC Preparation of an Isomerically Pure Drug Intermediate on Multikilogram Scale von Welch, Christopher J, Henderson, Derek W, Tschaen, David M, Miller, Ross A

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