Merck’s Reaction Review Policy: An Exercise in Process Safety von Bassan, Ephraim, Ruck, Rebecca T, Dienemann, Erik, Emerson, Khateeta M, Humphrey, Guy R, Raheem, Izzat T, Tschaen, David M, Vickery, Thomas P, Wood, Harold B, Yasuda, Nobuyoshi

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Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose von Nawrat, Christopher C, Whittaker, Aaron M, Huffman, Mark A, McLaughlin, Mark, Cohen, Ryan D, Andreani, Teresa, Ding, Bangwei, Li, Hongming, Weisel, Mark, Tschaen, David M

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Highly Selective Cascade Couplings for the Syntheses of Functionalized Piperidinones and Bispidines von Xu, Feng, Corley, Edward, Murry, Jerry A, Tschaen, David M

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Highly Efficient Synthesis of HIV NNRTI Doravirine von Gauthier, Donald R, Sherry, Benjamin D, Cao, Yang, Journet, Michel, Humphrey, Guy, Itoh, Tetsuji, Mangion, Ian, Tschaen, David M

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Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction von Humphrey, Guy R., Dalby, Stephen M., Andreani, Teresa, Xiang, Bangping, Luzung, Michael R., Song, Zhiguo Jake, Shevlin, Michael, Christensen, Melodie, Belyk, Kevin M., Tschaen, David M.

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A Mild Cu(I)-Catalyzed Oxidative Aromatization of Indolines to Indoles von Peng, Feng, McLaughlin, Mark, Liu, Yizhou, Mangion, Ian, Tschaen, David M, Xu, Yingju

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Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone von Patel, Niki R., Nawrat, Christopher C., McLaughlin, Mark, Xu, Yingju, Huffman, Mark A., Yang, Hao, Li, Hongming, Whittaker, Aaron M., Andreani, Teresa, Lévesque, François, Fryszkowska, Anna, Brunskill, Andrew, Tschaen, David M., Maloney, Kevin M.

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Preparative Chromatography with Extreme Productivity: HPLC Preparation of an Isomerically Pure Drug Intermediate on Multikilogram Scale von Welch, Christopher J, Henderson, Derek W, Tschaen, David M, Miller, Ross A

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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction von Hyde, Alan M, Liu, Zhijian, Kosjek, Birgit, Tan, Lushi, Klapars, Artis, Ashley, Eric R, Zhong, Yong-Li, Alvizo, Oscar, Agard, Nicholas J, Liu, Guiquan, Gu, Xiuyan, Yasuda, Nobuyoshi, Limanto, John, Huffman, Mark A, Tschaen, David M

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Practical Asymmetric Synthesis of Aprepitant, a Potent Human NK-1 Receptor Antagonist, via a Stereoselective Lewis Acid-Catalyzed Trans Acetalization Reaction von Zhao, Matthew M, McNamara, James M, Ho, Guo-Jie, Emerson, Khateeta M, Song, Zhiguo J, Tschaen, David M, Brands, Karel M. J, Dolling, Ulf-H, Grabowski, Edward J. J, Reider, Paul J, Cottrell, Ian F, Ashwood, Michael S, Bishop, Brian C

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Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle von Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M

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Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist von Song, Zhiguo J, Zhao, Mangzhu, Desmond, Richard, Devine, Paul, Tschaen, David M, Tillyer, Richard, Frey, Lisa, Heid, Richard, Xu, Feng, Foster, Bruce, Li, Jing, Reamer, Robert, Volante, Ralph, Dolling, Ulf H, Reider, Paul J, Okada, Shigemitsu, Kato, Yoshiaki, Mano, Eiichi

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An Efficient Asymmetric Synthesis of an Estrogen Receptor Modulator by Sulfoxide-Directed Borane Reduction von Song, Zhiguo J., King, Anthony O., Waters, Marjorie S., Lang, Fengrui, Zewge, Daniel, Bio, Matthew, Leazer, Johnnie L., Javadi, Gary, Kassim, Amude, Tschaen, David M., Reamer, Robert A., Rosner, Thorsten, Chilenski, Jennifer R., Mathre, David J., Volante, R. P., Tillyer, Richard, Trost, Barry M.

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Oxidation of Primary Alcohols to Carboxylic Acids with Sodium Chlorite Catalyzed by TEMPO and Bleach von Zhao, Mangzhu, Li, Jing, Mano, Eiichi, Song, Zhiguo, Tschaen, David M, Grabowski, Edward J. J, Reider, Paul J

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Stereoselective synthesis of 2-aryloxy esters: An asymmetric approach to fluoxetine, tomoxetine and nisoxetine von Devine, Paul N, Heid, Richard M, Tschaen, David M

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Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation von Song, Zhiguo J, Tellers, David M, Dormer, Peter G, Zewge, Daniel, Janey, Jacob M, Nolting, Andrew, Steinhuebel, Dietrich, Oliver, Steven, Devine, Paul N, Tschaen, David M

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Practical Asymmetric Synthesis of a Selective Endothelin A Receptor (ETA) Antagonist von Song, Zhiguo J, Zhao, Matthew, Frey, Lisa, Li, Jing, Tan, Lushi, Chen, Cheng Y, Tschaen, David M, Tillyer, Richard, Grabowski, Edward J. J, Volante, Ralph, Reider, Paul J, Kato, Yoshiaki, Okada, Shigemitsu, Nemoto, Takayuki, Sato, Hiroki, Akao, Atsushi, Mase, Toshiaki

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Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist von Larsen, Robert D, King, Anthony O, Chen, Cheng Y, Corley, Edward G, Foster, Bruce S, Roberts, F. Edward, Yang, Chunhua, Lieberman, David R, Reamer, Robert A, Tschaen, David M, Verhoeven, Thomas R, Reider, Paul J, Lo, Young S, Rossano, Lucius T, Brookes, A. Sidney, Meloni, David, Moore, James R, Arnett, John F

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Practical synthesis of a potent indolocarbazole-based, DNA topoisomerase inhibitor von Akao, Atsushi, Hiraga, Shouichi, Iida, Takehiko, Kamatani, Asayuki, Kawasaki, Masashi, Mase, Toshiaki, Nemoto, Takayuki, Satake, Nobuya, Weissman, Steven A, Tschaen, David M, Rossen, Kai, Petrillo, Daniel, Reamer, Robert A, Volante, R.P

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A novel chromium trioxide catalyzed oxidation of primary alcohols to the carboxylic acids von Zhao, Mangzhu, Li, Jing, Song, Zhiguo, Desmond, Richard, Tschaen, David M., Grabowski, Edward J.J., Reider, Paul J.

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