Peptidomimetic Therapeutic Agents Targeting the Protease Enzyme of the Human Immunodeficiency Virus and Hepatitis C Virus von Tsantrizos, Youla S

Volltext

Diastereoselective Synthesis of Phosphinyl Peptides via Rh-Catalyzed 1,4-Addition in Coparticipation of a P‑Chiral Moiety and Difluorphos von Kim, Taeok, Jin, Fuqing, Titi, Hatem M., Tsantrizos, Youla S.

Volltext

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase von Park, Jaeok, Rodionov, Dmitry, De Schutter, Joris W, Lin, Yih-Shyan, Tsantrizos, Youla S, Berghuis, Albert M

Volltext

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product von Park, Jaeok, Zielinski, Michal, Magder, Alexandr, Tsantrizos, Youla S., Berghuis, Albert M.

Volltext

P-Chiral, N-phosphoryl sulfonamide Brønsted acids with an intramolecular hydrogen bond interaction that modulates organocatalysis von Yuan, Minglei, Mbaezue, Ifenna I, Zhou, Zhi, Topic, Filip, Tsantrizos, Youla S

Volltext

Isoprenoids and tau pathology in sporadic Alzheimer's disease von Pelleieux, Sandra, Picard, Cynthia, Lamarre-Théroux, Louise, Dea, Doris, Leduc, Valérie, Tsantrizos, Youla S., Poirier, Judes

Volltext

Asymmetric Library Synthesis of P‑Chiral t‑Butyl-Substituted Secondary and Tertiary Phosphine Oxides von Li, Shi-Guang, Yuan, Minglei, Topic, Filip, Han, Zhengxu S, Senanayake, Chris H, Tsantrizos, Youla S

Volltext

Synthesis and Evaluation of Structurally Diverse C‑2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase von Lee, Hiu-Fung, Lacbay, Cyrus M, Boutin, Rebecca, Matralis, Alexios N, Park, Jaeok, Waller, Daniel D, Guan, Tian Lai, Sebag, Michael, Tsantrizos, Youla S

Volltext

Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor E... von Boutin, Rebecca, Lee, Hiu-Fung, Guan, Tian Lai, Nguyen, Tan Trieu, Huang, Xian Fang, Waller, Daniel D., Lu, Jordan, Christine Chio, Iok In, Michel, René P., Sebag, Michael, Tsantrizos, Youla S.

Volltext

Chirality-Driven Mode of Binding of α‑Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS) von Feng, Yuting, Park, Jaeok, Li, Shi-Guang, Boutin, Rebecca, Viereck, Peter, Schilling, Matthew A, Berghuis, Albert M, Tsantrizos, Youla S

Volltext

Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition von Leung, Chun Yuen, Park, Jaeok, De Schutter, Joris W, Sebag, Michael, Berghuis, Albert M, Tsantrizos, Youla S

Volltext

Synthesis of Benzothiophene-Containing 10- and 11-Membered Cyclic Phostones von Matralis, Alexios N., Tsantrizos, Youla S.

Volltext

Molecular tools that block maturation of the nuclear lamin A and decelerate cancer cell migration von Matralis, Alexios N., Xanthopoulos, Dimitrios, Huot, Geneviève, Lopes-Paciencia, Stéphane, Cole, Charles, de Vries, Hugo, Ferbeyre, Gerardo, Tsantrizos, Youla S.

Volltext

Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase—Parallel synthesis of analogs via a trimethylsilyl ylidene intermediate von Leung, Chun-Yuen, Langille, Adrienne M, Mancuso, John, Tsantrizos, Youla S

Volltext

Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases von De Schutter, Joris W, Park, Jaeok, Leung, Chun Yuen, Gormley, Patrick, Lin, Yih-Shyan, Hu, Zheping, Berghuis, Albert M, Poirier, Judes, Tsantrizos, Youla S

Volltext

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1 von Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla

Volltext

Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection von Tsantrizos, Youla S., Bolger, Gordon, Bonneau, Pierre, Cameron, Dale R., Goudreau, Nathalie, Kukolj, George, LaPlante, Steven R., Llinàs-Brunet, Montse, Nar, Herbert, Lamarre, Daniel

Volltext

Conformation-Based Restrictions and Scaffold Replacements in the Design of Hepatitis C Virus Polymerase Inhibitors: Discovery of Deleobuvir (BI 207127) von LaPlante, Steven R., Bös, Michael, Brochu, Christian, Chabot, Catherine, Coulombe, René, Gillard, James R., Jakalian, Araz, Poirier, Martin, Rancourt, Jean, Stammers, Timothy, Thavonekham, Bounkham, Beaulieu, Pierre L., Kukolj, George, Tsantrizos, Youla S.

Volltext

Metal-Free Cycloetherification by in Situ Generated P‑Stereogenic α‑Diazanium Intermediates: A Convergent Synthesis of Enantiomerically Pure Dihydrobenzooxaphospholes von Li, Shi-Guang, Han, Zhengxu S, Viereck, Peter, Lee, Heewon, Kurouski, Dmitry, Senanayake, Chris H, Tsantrizos, Youla S

Volltext

Copper-boryl mediated transfer hydrogenation of N-sulfonyl imines using methanol as the hydrogen donor von He, Yi, Li, Shi-Guang, Mbaezue, Ifenna I., Reddy, Angula C.S., Tsantrizos, Youla S.

Volltext