Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the I... von Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

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Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors von Casimiro-Garcia, Agustin, Trujillo, John I, Vajdos, Felix, Juba, Brian, Banker, Mary Ellen, Aulabaugh, Ann, Balbo, Paul, Bauman, Jonathan, Chrencik, Jill, Coe, Jotham W, Czerwinski, Robert, Dowty, Martin, Knafels, John D, Kwon, Soojin, Leung, Louis, Liang, Sidney, Robinson, Ralph P, Telliez, Jean-Baptiste, Unwalla, Ray, Yang, Xin, Thorarensen, Atli

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Structural basis for CCR6 modulation by allosteric antagonists von Wasilko, David Jonathan, Gerstenberger, Brian S., Farley, Kathleen A., Li, Wei, Alley, Jennifer, Schnute, Mark E., Unwalla, Ray J., Victorino, Jorge, Crouse, Kimberly K., Ding, Ru, Sahasrabudhe, Parag V., Vincent, Fabien, Frisbie, Richard K., Dermenci, Alpay, Flick, Andrew, Choi, Chulho, Chinigo, Gary, Mousseau, James J., Trujillo, John I., Nuhant, Philippe, Mondal, Prolay, Lombardo, Vincent, Lamb, Daniel, Hogan, Barbara J., Minhas, Gurdeep Singh, Segala, Elena, Oswald, Christine, Windsor, Ian W., Han, Seungil, Rappas, Mathieu, Cooke, Robert M., Calabrese, Matthew F., Berstein, Gabriel, Thorarensen, Atli, Wu, Huixian

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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-... von Fensome, Andrew, Ambler, Catherine M, Arnold, Eric, Banker, Mary Ellen, Brown, Matthew F, Chrencik, Jill, Clark, James D, Dowty, Martin E, Efremov, Ivan V, Flick, Andrew, Gerstenberger, Brian S, Gopalsamy, Ariamala, Hayward, Matthew M, Hegen, Martin, Hollingshead, Brett D, Jussif, Jason, Knafels, John D, Limburg, David C, Lin, David, Lin, Tsung H, Pierce, Betsy S, Saiah, Eddine, Sharma, Raman, Symanowicz, Peter T, Telliez, Jean-Baptiste, Trujillo, John I, Vajdos, Felix F, Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin, Zhang, Liying

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PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor von Xu, Hua, Jesson, Michael I, Seneviratne, Uthpala I, Lin, Tsung H, Sharif, M. Nusrat, Xue, Liang, Nguyen, Chuong, Everley, Robert A, Trujillo, John I, Johnson, Douglas S, Point, Gary R, Thorarensen, Atli, Kilty, Iain, Telliez, Jean-Baptiste

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Elucidation of a Sequential Iminium Ion Cascade Reaction Triggered by a Silica Gel-Promoted Aza-Peterson Reaction von Jones, Elizabeth V, Chen, Doris, Wright, Stephen W, Trujillo, John I, France, Stefan

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Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters von Trujillo, John I., Kiefer, James R., Huang, Wei, Day, Jacqueline E., Moon, Joseph, Jerome, Gina M., Bono, Christine P., Kornmeier, Christine M., Williams, Melanie L., Kuhn, Cyrille, Rennie, Glen R., Wynn, Thomas A., Carron, Christopher P., Thorarensen, Atli

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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition von Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

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Practical Kilogram Synthesis of (S)‑1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine von Lombardo, Vincent M, Bernier, Louise, Chen, Ming Z, Farrell, William, Flick, Andrew, Nuhant, Philippe, Sach, Neal W, Tao, Yong, Trujillo, John I

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A Parallel Approach to 7‑(Hetero)arylpyrazolo[1,5‑a]pyrimidin-5-ones von Schmitt, Daniel C, Niljianskul, Nootaree, Sach, Neal W, Trujillo, John I

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Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1 von Fensome, Andrew, Ambler, Catherine M., Arnold, Eric, Banker, Mary Ellen, Clark, James D., Dowty, Martin E., Efremov, Ivan V., Flick, Andrew, Gerstenberger, Brian S., Gifford, Roger S., Gopalsamy, Ariamala, Hegen, Martin, Jussif, Jason, Limburg, David C., Lin, Tsung H., Pierce, Betsy S., Sharma, Raman, Trujillo, John I., Vajdos, Felix F., Vincent, Fabien, Wan, Zhao-Kui, Xing, Li, Yang, Xiaojing, Yang, Xin

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Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists von Schnute, Mark E., Trujillo, John I., Lee, Katherine L., Unwalla, Ray, Vajdos, Felix F., Kauppi, Björn, Nuhant, Philippe, Flick, Andrew C., Crouse, Kimberly K., Zhao, Yajuan, Samuel, Amanda, Lombardo, Vincent, Taylor, Alexandria P., Brault, Amy L., Knafels, John D., Vazquez, Michael L., Berstein, Gabriel

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Process Development and Scale Up of a Selective JAK3 Covalent Inhibitor PF-06651600 von Tao, Yong, McWilliams, J. Christopher, Wiglesworth, Kristin E, Girard, Kevin P, Makowski, Teresa M, Sach, Neal W, Mustakis, Jason G, Mehta, Ruchi, Trujillo, John I, Chen, Xiaofeng, Li, Tangqing, Shi, Feng, Xie, Chengfu, Zhang, Qing

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Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) von Trujillo, John I., Meyers, Marvin J., Anderson, David R., Hegde, Shridhar, Mahoney, Matthew W., Vernier, William F., Buchler, Ingrid P., Wu, Kun K., Yang, Syaluan, Hartmann, Susan J., Reitz, David B.

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Effect of the acidic component on the Mitsunobu inversion of a sterically hindered alcohol von Dodge, Jeffrey A, Trujillo, John I, Presnell, Misti

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Aminopyrazole Carboxamide Bruton’s Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning von Schnute, Mark E, Benoit, Stephen E, Buchler, Ingrid P, Caspers, Nicole, Grapperhaus, Margaret L, Han, Seungil, Hotchandani, Rajeev, Huang, Nelson, Hughes, Robert O, Juba, Brian M, Kim, Kyung-Hee, Liu, Erica, McCarthy, Erin, Messing, Dean, Miyashiro, Joy S, Mohan, Shashi, O’Connell, Thomas N, Ohren, Jeffrey F, Parikh, Mihir D, Schmidt, Michelle, Selness, Shaun R, Springer, John R, Thanabal, Venkataraman, Trujillo, John I, Walker, Daniel P, Wan, Zhao-Kui, Withka, Jane M, Wittwer, Arthur J, Wood, Nancy L, Xing, Li, Zapf, Christoph W, Douhan, John

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2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor von Trujillo, John I, Kiefer, James R, Huang, Wei, Thorarensen, Atli, Xing, Li, Caspers, Nicole L, Day, Jacqueline E, Mathis, Karl J, Kretzmer, Kuniko K, Reitz, Beverley A, Weinberg, Robin A, Stegeman, Roderick A, Wrightstone, Ann, Christine, Lori, Compton, Robert, Li, Xiong

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Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs von Trujillo, John I., Huang, Wei, Hughes, Robert O., Joseph Rogier, D., Turner, Steven R., Devraj, Rajesh, Morton, Philip A., Xue, Chu-Biao, Chao, Ganfeng, Covington, Maryanne B., Newton, Robert C., Metcalf, Brian

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Design, synthesis, and biological evaluation of pyrazinones containing novel P1 needles as inhibitors of TF/VIIa von Trujillo, John I., Huang, Horng-Chih, Neumann, William L., Mahoney, Matthew W., Long, Scott, Huang, Wei, Garland, Danny J., Kusturin, Carrie, Abbas, Zaheer, South, Michael S., Reitz, David B.

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Efforts towards Rh(II)-catalyzed N-alkoxyazomethine ylide generation: Disparate reactivities of O-tethered α-diazo keto and -β-ketoester oximes von Chen, Doris, Jones, Elizabeth V., Rocke, Benjamin N., Flick, Andrew C., Wright, Stephen W., Trujillo, John I., France, Stefan

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