Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody von Zhang, Jun, Woods, Christopher, He, Feng, Han, Mei, Treuheit, Michael J, Volkin, David B

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Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints von Clark, Nicholas J, Zhang, Hailiang, Krueger, Susan, Lee, Hyo Jin, Ketchem, Randal R, Kerwin, Bruce, Kanapuram, Sekhar R, Treuheit, Michael J, McAuley, Arnold, Curtis, Joseph E

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Characterization of Site-Specific Glycation During Process Development of a Human Therapeutic Monoclonal Antibody von Miller, Amanda K., Hambly, David M., Kerwin, Bruce A., Treuheit, Michael J., Gadgil, Himanshu S.

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Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies von Chelius, Dirk, Jing, Kay, Lueras, Alexis, Rehder, Douglas S, Dillon, Thomas M, Vizel, Alona, Rajan, Rahul S, Li, Tiansheng, Treuheit, Michael J, Bondarenko, Pavel V

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Screening and Sequencing of Glycated Proteins by Neutral Loss Scan LC/MS/MS Method von Gadgil, Himanshu S, Bondarenko, Pavel V, Treuheit, Michael J, Ren, Da

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Effects of Monovalent Salt on Protein-Protein Interactions of Dilute and Concentrated Monoclonal Antibody Formulations von Xu, Amy Y, Clark, Nicholas J, Pollastrini, Joseph, Espinoza, Maribel, Kim, Hyo-Jin, Kanapuram, Sekhar, Kerwin, Bruce, Treuheit, Michael J, Krueger, Susan, McAuley, Arnold, Curtis, Joseph E

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Comparison of LC and LC/MS Methods for Quantifying N-Glycosylation in Recombinant IgGs von Sinha, Sandipan, Pipes, Gary, Topp, Elizabeth M., Bondarenko, Pavel V., Treuheit, Michael J., Gadgil, Himanshu S.

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Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the CH1 Domain of Human Antibodies von Valliere-Douglass, John F., Kodama, Paul, Mujacic, Mirna, Brady, Lowell J., Wang, Wes, Wallace, Alison, Yan, Boxu, Reddy, Pranhitha, Treuheit, Michael J., Balland, Alain

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Inverse relationship of protein concentration and aggregation von TREUHEIT, Michael J, KOSKY, Andrew A, BREMS, David N

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Aggregation of granulocyte‐colony stimulating factor in vitro involves a conformationally altered monomeric state von Raso, Stephen W., Abel, Jeff, Barnes, Jesse M., Maloney, Kevin M., Pipes, Gary, Treuheit, Michael J., King, Jonathan, Brems, David N.

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Formulation of Neulasta® (pegfilgrastim) von Piedmonte, Deirdre Murphy, Treuheit, Michael J.

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Accelerated Formulation Development of Monoclonal Antibodies (mAbs) and mAb-Based Modalities: Review of Methods and Tools von Razinkov, Vladimir I., Treuheit, Michael J., Becker, Gerald W.

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Control of Antibody Impurities Induced by Riboflavin in Culture Media During Production von Wallace, Alison, Trimble, Stephen, Valliere-Douglass, John F., Allen, Martin, Eakin, Catherine, Balland, Alain, Reddy, Pranhitha, Treuheit, Michael J.

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Improving mass accuracy of high performance liquid chromatography/ electrospray ionization time-of-flight mass spectrometry of intact antibodies von GADGIL, Himanshu S, PIPES, Gary D, DILLON, Thomas M, TREUHEIT, Michael J, BONDARENKO, Pavel V

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An improved trypsin digestion method minimizes digestion-induced modifications on proteins von Ren, Da, Pipes, Gary D., Liu, Dingjiang, Shih, Liang-Yu, Nichols, Andrew C., Treuheit, Michael J., Brems, David N., Bondarenko, Pavel V.

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Effects of Sucrose and Benzyl Alcohol on GCSF Conformational Dynamics Revealed by Hydrogen Deuterium Exchange Mass Spectrometry von Zhang, Jun, Banks, Douglas D., He, Feng, Treuheit, Michael J., Becker, Gerald W.

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Optimization and applications of CDAP labeling for the assignment of cysteines von Pipes, Gary D, Kosky, Andrew A, Abel, Jeffrey, Zhang, Yu, Treuheit, Michael J, Kleemann, Gerd R

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High-Throughput Screening and Stability Optimization of Anti-Streptavidin IgG1 and IgG2 Formulations von Alekseychyk, Larysa, Su, Cheng, Becker, Gerald W., Treuheit, Michael J., Razinkov, Vladimir I.

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Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis von Gadgil, Himanshu S., Bondarenko, Pavel V., Pipes, Gary D., Dillon, Thomas M., Banks, Douglas, Abel, Jeffrey, Kleemann, Gerd R., Treuheit, Michael J.

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Optimized UV Detection of High-Concentration Antibody Formulations using High-Throughput SE-HPLC von Molloy, Shabnam, Mathew Fesinmeyer, R., Martinez, Theresa, Murphy, Piedmonte D., Pelletier, Mary E., Treuheit, Michael J., Kleemann, Gerd R.

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