The importance of plasma protein binding in drug discovery von Trainor, George L

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Discovery of N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficac... von Schroeder, Gretchen M, An, Yongmi, Cai, Zhen-Wei, Chen, Xiao-Tao, Clark, Cheryl, Cornelius, Lyndon A. M, Dai, Jun, Gullo-Brown, Johnni, Gupta, Ashok, Henley, Benjamin, Hunt, John T, Jeyaseelan, Robert, Kamath, Amrita, Kim, Kyoung, Lippy, Jonathan, Lombardo, Louis J, Manne, Veeraswamy, Oppenheimer, Simone, Sack, John S, Schmidt, Robert J, Shen, Guoxiang, Stefanski, Kevin, Tokarski, John S, Trainor, George L, Wautlet, Barri S, Wei, Donna, Williams, David K, Zhang, Yingru, Zhang, Yueping, Fargnoli, Joseph, Borzilleri, Robert M

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors von Li, Guo, Meanwell, Nicholas A, Krystal, Mark R, Langley, David R, Naidu, B. Narasimhulu, Sivaprakasam, Prasanna, Lewis, Hal, Kish, Kevin, Khan, Javed A, Ng, Alicia, Trainor, George L, Cianci, Christopher, Dicker, Ira B, Walker, Michael A, Lin, Zeyu, Protack, Tricia, Discotto, Linda, Jenkins, Susan, Gerritz, Samuel W, Pendri, Annapurna

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BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR von Carboni, Joan M, Wittman, Mark, Yang, Zheng, Lee, Francis, Greer, Ann, Hurlburt, Warren, Hillerman, Stephen, Cao, Carolyn, Cantor, Glenn H, Dell-John, Janet, Chen, Cliff, Discenza, Lorell, Menard, Krista, Li, Aixin, Trainor, George, Vyas, Dolatrai, Kramer, Robert, Attar, Ricardo M, Gottardis, Marco M

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Discovery of Pyrrolopyridine−Pyridone Based Inhibitors of Met Kinase: Synthesis, X-ray Crystallographic Analysis, and Biological Activities von Kim, Kyoung Soon, Zhang, Liping, Schmidt, Robert, Cai, Zhen-Wei, Wei, Donna, Williams, David K, Lombardo, Louis J, Trainor, George L, Xie, Dianlin, Zhang, Yaquan, An, Yongmi, Sack, John S, Tokarski, John S, Darienzo, Celia, Kamath, Amrita, Marathe, Punit, Zhang, Yueping, Lippy, Jonathan, Jeyaseelan, Robert, Wautlet, Barri, Henley, Benjamin, Gullo-Brown, Johnni, Manne, Veeraswamy, Hunt, John T, Fargnoli, Joseph, Borzilleri, Robert M

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Trends in Kinase Selectivity: Insights for Target Class-Focused Library Screening von Posy, Shana L, Hermsmeier, Mark A, Vaccaro, Wayne, Ott, Karl-Heinz, Todderud, Gordon, Lippy, Jonathan S, Trainor, George L, Loughney, Deborah A, Johnson, Stephen R

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Cyclin-Dependent Kinase Inhibitors:  Useful Targets in Cell Cycle Regulation von Sielecki, Thais M, Boylan, John F, Benfield, Pamela A, Trainor, George L

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Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1) von Huynh, Tram, Chen, Zhong, Pang, Suhong, Geng, Jieping, Bandiera, Tiziano, Bindi, Simona, Vianello, Paola, Roletto, Fulvia, Thieffine, Sandrine, Galvani, Arturo, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.

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Inhibition of Clinically Relevant Mutant Variants of HIV-1 by Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors von Corbett, Jeffrey W, Ko, Soo S, Rodgers, James D, Gearhart, Lisa A, Magnus, Nicholas A, Bacheler, Lee T, Diamond, Sharon, Jeffrey, Susan, Klabe, Ronald M, Cordova, Beverly C, Garber, Sena, Logue, Kelly, Trainor, George L, Anderson, Paul S, Erickson-Viitanen, Susan K

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9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors von Zimmermann, Kurt, Sang, Xiaopeng, Mastalerz, Harold A., Johnson, Walter L., Zhang, Guifen, Liu, Qingjie, Batt, Douglas, Lombardo, Louis J., Vyas, Dinesh, Trainor, George L., Tokarski, John S., Lorenzi, Matthew V., You, Dan, Gottardis, Marco M., Lippy, Jonathan, Khan, Javed, Sack, John S., Purandare, Ashok V.

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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases von Markwalder, Jay A, Arnone, Marc R, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Chang, Chong-Hwan, Cox, Sarah S, Czerniak, Philip M, Dean, Charity L, Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A, Kaltenbach, Robert F, Nugiel, David A, Rossi, Karen A, Sherk, Susan R, Sisk, Lisa M, Stouten, Pieter, Trainor, George L, Worland, Peter, Seitz, Steven P

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Benzo[ d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies von Wan, Honghe, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.

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Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms von Wan, Honghe, Schroeder, Gretchen M, Hart, Amy C, Inghrim, Jennifer, Grebinski, James, Tokarski, John S, Lorenzi, Matthew V, You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J, Trainor, George L, Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S, Khan, Javed A, Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K, Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N, Pragalathan, Bala, Narayanan, Sankara, K.C, Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V

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Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity von Albright, Charles F, Graciani, Nilsa, Han, Wei, Yue, Eddy, Stein, Ross, Lai, Zhihong, Diamond, Melody, Dowling, Randine, Grimminger, Lisa, Zhang, Shu-Yun, Behrens, Davette, Musselman, Amy, Bruckner, Robert, Zhang, Mingzhu, Jiang, Xiang, Hu, Daniel, Higley, Anne, Dimeo, Susan, Rafalski, Maria, Mandlekar, Sandya, Car, Bruce, Yeleswaram, Swamy, Stern, Andrew, Copeland, Robert A, Combs, Andrew, Seitz, Steve P, Trainor, George L, Taub, Rebecca, Huang, Pearl, Oliff, Allen

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Modulation of cofilin phosphorylation by inhibition of the Lim family kinases von He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An

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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer von Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D, Trainor, George L, Gottardis, Marco M, Spires, Thomas E, Spires, Vanessa M, Rizzo, Cheryl A, Obermeier, Mary T, Elzinga, Paul A, Todderud, Gordon, Fan, Yi, Newitt, John A, Beyer, Sophie M, Zhu, Yongxin, Warrack, Bethanne M, Goodenough, Angela K, Tebben, Andrew J, Doweyko, Arthur M, Gold, David L, Balog, Aaron

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Expanded-Spectrum Nonnucleoside Reverse Transcriptase Inhibitors Inhibit Clinically Relevant Mutant Variants of Human Immunodeficiency Virus Type 1 von Corbett, J W, Ko, S S, Rodgers, J D, Jeffrey, S, Bacheler, L T, Klabe, R M, Diamond, S, Lai, C M, Rabel, S R, Saye, J A, Adams, S P, Trainor, G L, Anderson, P S, Erickson-Viitanen, S K

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Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5‑d]pyrrolo[2,3‑b]pyridine Inhibitors von Hart, Amy C, Schroeder, Gretchen M, Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J, Tokarski, John S, Sack, John S, Khan, Javed A, Lippy, Jonathan, Lorenzi, Matthew V, You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J, Trainor, George L, Purandare, Ashok V

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Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors von Patel, Mona, McHugh, Robert J, Cordova, Beverly C, Klabe, Ronald M, Erickson-Viitanen, Susan, Trainor, George L, Rodgers, James D

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Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series von Tarby, Christine M., Kaltenbach, Robert F., Huynh, Tram, Pudzianowski, Andrew, Shen, Henry, Ortega-Nanos, Marie, Sheriff, Steven, Newitt, John A., McDonnell, Patricia A., Burford, Neil, Fairchild, Craig R., Vaccaro, Wayne, Chen, Zhong, Borzilleri, Robert M., Naglich, Joseph, Lombardo, Louis J., Gottardis, Marco, Trainor, George L., Roussell, Deborah L.

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