Editorial: Mitochondrial Biology and Its Role in Metabolic Diseases von Schneider, Jochen G., Tozzo, Effie, Chakravarthy, Manu V.

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Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes von Augeri, David J, Robl, Jeffrey A, Betebenner, David A, Magnin, David R, Khanna, Ashish, Robertson, James G, Wang, Aiying, Simpkins, Ligaya M, Taunk, Prakash, Huang, Qi, Han, Song-Ping, Abboa-Offei, Benoni, Cap, Michael, Xin, Li, Tao, Li, Tozzo, Effie, Welzel, Gustav E, Egan, Donald M, Marcinkeviciene, Jovita, Chang, Shu Y, Biller, Scott A, Kirby, Mark S, Parker, Rex A, Hamann, Lawrence G

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Pioglitazone increases whole body insulin sensitivity in obese, insulin-resistant rhesus monkeys von Tozzo, Effie, Bhat, Gowri, Cheon, Kyeongmi, Camacho, Raul C

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Effects of a Novel Glycogen Synthase Kinase-3 Inhibitor on Insulin-Stimulated Glucose Metabolism in Zucker Diabetic Fatty (fa/fa) Rats von CLINE, Gary W, JOHNSON, Kirk, REGITTNIG, Werner, PERRET, Pascale, TOZZO, Effie, XIAO, Linda, DAMICO, Christine, SHULMAN, Gerald I

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Semi-automated quantitative image analysis of podocyte desmin immunoreactivity as a sensitive marker for acute glomerular damage in the rat puromycin aminonucleoside nephrosis (PAN... von Herrmann, Annika, Tozzo, Effie, Funk, Jürgen

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735 Identification of a small molecule that prevents T cell exhaustion using machine learning algorithms paired with high-resolution single cell RNAseq von Mercier, Isabelle Le, Sun, Sunny, Xiao, Dongmei, Isacco, Laura, Treacy, Daniel, Artru, Emilie, Steelman, Scott, Bradley, John, Wolf, Alex, Stewart, Morag, Tozzo, Effie

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Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists von Cox, Jason M, Chu, Hong D, Chelliah, Mariappan V, Debenham, John S, Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A, Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M, Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R, Crespo, Alejandro, Madeira, Maria, Leung, Dennis H, Alleyne, Candice, Ogawa, Aimie M, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E, Ujjainwalla, Feroze, Tata, James R, Sinz, Christopher J

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In vitro and in vivo proof-of-concept studies of extracellular protein degradation using novel M6PR-targeting chimeras (MTACs) von Molz, Lisa, Liu, Hu, Zhu, Nanqun, Karra, Srinivasa, Tozzo, Effie

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GLUT4 Overexpression or Deficiency in Adipocytes of Transgenic Mice Alters the Composition of GLUT4 Vesicles and the Subcellular Localization of GLUT4 and Insulin-responsive Aminop... von Carvalho, Eugenia, Schellhorn, Sarah E, Zabolotny, Janice M, Martin, Sally, Tozzo, Effie, Peroni, Odile D, Houseknecht, Karen L, Mundt, Adrian, James, David E, Kahn, Barbara B

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Identification of Small Molecules That Induce Therapeutic Levels of Fetal Hemoglobin for Treatment of Sickle Cell Disease By Pairing Machine Learning with High-Resolution Single Ce... von Cortes, Mauricio, Monti, Anthony J, Sun, Sunny, Lynch, Orna, Xia, Youli, Lin, Sarah, Malamas, Michael, Steelman, Scott, Krishnamoorthy, Sriram, Stewart, Morag, Tozzo, Effie

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PPARδ modulation rescues mitochondrial fatty acid oxidation defects in the mdx model of muscular dystrophy von Bell, Eric L, Shine, Robert W, Dwyer, Peter, Olson, Lyndsay, Truong, Jennifer, Fredenburg, Ross, Goddeeris, Matthew, Stickens, Dominique, Tozzo, Effie

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Gene expression in WAT from healthy humans and monkeys correlates with FGF21‐induced browning of WAT in mice von Schlessinger, Karni, Li, Wenyu, Tan, Yejun, Liu, Franklin, Souza, Sandra C., Tozzo, Effie, Liu, Kevin, Thompson, John R., Wang, Liangsu, Muise, Eric S.

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Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing von Lagu, Bharat, Kluge, Arthur F., Fredenburg, Ross A., Tozzo, Effie, Senaiar, Ramesh S., Jaleel, Mahaboobi, Panigrahi, Sunil K., Tiwari, Nirbhay K., Krishnamurthy, Narasimha R., Takahashi, Taisuke, Patane, Michael A.

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Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516 von Lagu, Bharat, Kluge, Arthur F., Goddeeris, Matthew M., Tozzo, Effie, Fredenburg, Ross A., Chellur, Shekar, Senaiar, Ramesh S., Jaleel, Mahaboobi, Babu, D. Ravi Krishna, Tiwari, Nirbhay K., Takahashi, Taisuke, Patane, Michael A.

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Gene expression in WAT from healthy humans and monkeys correlates with FGF 21‐induced browning of WAT in mice von Schlessinger, Karni, Li, Wenyu, Tan, Yejun, Liu, Franklin, Souza, Sandra C., Tozzo, Effie, Liu, Kevin, Thompson, John R., Wang, Liangsu, Muise, Eric S.

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Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD) von Lagu, Bharat, Kluge, Arthur F, Tozzo, Effie, Fredenburg, Ross, Bell, Eric L, Goddeeris, Matthew M, Dwyer, Peter, Basinski, Andrew, Senaiar, Ramesh S, Jaleel, Mahaboobi, Tiwari, Nirbhay Kumar, Panigrahi, Sunil K, Krishnamurthy, Narasimha Rao, Takahashi, Taisuke, Patane, Michael A

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Correction to “Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)” von Lagu, Bharat, Kluge, Arthur F, Tozzo, Effie, Fredenburg, Ross, Bell, Eric L, Goddeeris, Matthew M, Dwyer, Peter, Basinski, Andrew, Senaiar, Ramesh S, Jaleel, Mahaboobi, Tiwari, Nirbhay Kumar, Panigrahi, Sunil K, Krishnamurthy, Narasimha Rao, Takahashi, Taisuke, Patane, Michael A

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Targeted Disruption of the β3-Adrenergic Receptor Gene von Susulic, Vedrana S., Frederich, Robert C., Lawitts, Joel, Tozzo, Effie, Kahn, Barbara B., Harper, Mary-Ellen, Himms-Hagen, Jean, Flier, Jeffrey S., Lowell, Bradford B.

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Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of Type-2 diabetes von Kitas, Eric, Mohr, Peter, Kuhn, Bernd, Hebeisen, Paul, Wessel, Hans Peter, Haap, Wolfgang, Ruf, Armin, Benz, Jörg, Joseph, Catherine, Huber, Walter, Sanchez, Ruben Alvarez, Paehler, Axel, Benardeau, Agnes, Gubler, Marcel, Schott, Brigitte, Tozzo, Effie

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Amelioration of Insulin Resistance in Streptozotocin Diabetic Mice by Transgenic Overexpression of GLUT4 Driven by an Adipose-Specific Promoter1 von Tozzo, Effie, Gnudi, Luigi, Kahn, Barbara B

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