Combination of intensive chemotherapy and imatinib can rapidly induce high-quality complete remission for a majority of patients with newly diagnosed BCR-ABL–positive acute lymphob... von Towatari, Masayuki, Yanada, Masamitsu, Usui, Noriko, Takeuchi, Jin, Sugiura, Isamu, Takeuchi, Makoto, Yagasaki, Fumiharu, Kawai, Yasukazu, Miyawaki, Shuichi, Ohtake, Shigeki, Jinnai, Itsuro, Matsuo, Keitaro, Naoe, Tomoki, Ohno, Ryuzo

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Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product von KIYOI, H, TOWATARI, M, YOKOTA, S, HAMAGUCHI, M, OHNO, R, SAITO, H, NAOE, T

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Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells von Maeda, Takahiro, Towatari, Masayuki, Kosugi, Hiroshi, Saito, Hidehiko

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Lyn is an important component of the signal transduction pathway specific to FLT3 ITD and can be a therapeutic target in the treatment of AML with FLT3 ITD von OKAMOTO, M, HAYAKAWA, F, MIYATA, Y, WATAMOTO, K, EMI, N, ABE, A, KIYOI, H, TOWATARI, M, NAOE, T

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Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia : a new approach to anti-leukemia therapy von KOSUGI, H, TOWATARI, M, NAOE, T, HATANO, S, KITAMURA, K, KIYOI, H, KINOSHITA, T, TANIMOTO, M, MURATE, T, KAWASHIMA, K, SAITO, H

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Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12) von KUNO, Yoshie, ABE, Akihiro, EMI, Nobuhiko, LIDA, Minako, YOKOZAWA, Toshiya, TOWATARI, Masayuki, TANIMOTO, Mitsune, SAITO, Hidehiko

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Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells von TOWATARI, M, LIDA, H, TANIMOTO, M, IWATA, H, HAMAGUCHI, M, SAITO, H

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Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein von Tsuzuki, Shinobu, Towatari, Masayuki, Saito, Hidehiko, Enver, Tariq

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TEL-Syk fusion constitutively activates P13-K/Akt, MAPK and JAK2-independent STAT5 signal pathways von KANIE, T, ABE, A, MATSUDA, T, KUNO, Y, TOWATARI, M, YAMAMOTO, T, SAITO, H, EMI, N, NAOE, T

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Regulation of the myeloperoxidase enhancer binding proteins Pu1, C-EBP alpha, -beta, and -delta during granulocyte-lineage specification von Ford, A M, Bennett, C A, Healy, L E, Towatari, M, Greaves, M F, Enver, T

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In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor von ZHAO, M, KIYOI, H, YAMAMOTO, Y, ITO, M, TOWATARI, M, ÖMURA, S, KITAMURA, T, UEDA, R, SAITO, H, NAOE, T

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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines von HAYAKAWA, F, TOWATARI, M, KIYOI, H, TANIMOTO, M, KITAMURA, T, SAITO, H, NAOE, T

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Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation von LIDA, M, TOWATARI, M, NAKAO, A, LIDA, H, KIYOI, H, NAKANO, Y, TANIMOTO, M, SAITO, H, NAOE, T

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Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation von WATAMOTO, Kouichi, TOWATARI, Masayuki, OZAWA, Yukiyasu, MIYATA, Yasuhiko, OKAMOTO, Mitsunori, ABE, Akihiro, NAOE, Tomoki, SAITO, Hidehiko

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Functional regulation of GATA-2 by acetylation von Hayakawa, F.

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Histone deacetylase 3 associates with and represses the transcription factor GATA-2 von Ozawa, Yukiyasu, Towatari, Masayuki, Tsuzuki, Shinobu, Hayakawa, Fumihiko, Maeda, Takahiro, Miyata, Yasuhiko, Tanimoto, Mitsune, Saito, Hidehiko

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Life‐threatening human parvovirus B19 infection transmitted by intravenous immune globulin von Hayakawa, Fumihiko, Imada, Kazumi, Towatari, Masayuki, Saito, Hidehiko

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c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300 von TOMITA, A, TOWATARI, M, TSUZUKI, S, HAYAKAWA, F, KOSUGI, H, TAMAI, K, MIYAZAKI, T, KINOSHITA, T, SAITO, H

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In vivo Effects of a Histone Deacetylase Inhibitor, FK228, on Human Acute Promyelocytic Leukemia in NOD/Shi‐scid/scid Mice von Kosugi, Hiroshi, Ito, Masafumi, Yamamoto, Yukiya, Towatari, Masayuki, Ito, Mamoru, Ueda, Ryuzo, Saito, Hidehiko, Naoe, Tomoki

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TEL-Syk fusion constitutively activates PI3-K Akt, MAPK and JAK2-independent STAT5 signal pathways von Kanie, T, Abe, A, Matsuda, T, Kuno, Y, Towatari, M, Yamamoto, T, Saito, H, Emi, N, Naoe, T

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