Roscovitine Targets, Protein Kinases and Pyridoxal Kinase[boxs] von Bach, Stéphane, Knockaert, Marie, Reinhardt, Jens, Lozach, Olivier, Schmitt, Sophie, Baratte, Blandine, Koken, Marcel, Coburn, Stephen P., Tang, Lin, Jiang, Tao, Liang, Dong-cai, Galons, Hervé, Dierick, Jean-Francois, Pinna, Lorenzo A., Meggio, Flavio, Totzke, Frank, Schächtele, Christoph, Lerman, Andrea S., Carnero, Amancio, Wan, Yongqin, Gray, Nathanael, Meijer, Laurent

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7-Bromoindirubin-3′-oxime induces caspase-independent cell death von RIBAS, J, BETTAYEB, K, SKALTSOUNIS, A.-L, BOIX, J, MEIJER, L, FERANDIN, Y, KNOCKAERT, M, GARROFE-OCHOA, X, TOTZKE, F, SCHÄCHTELE, C, MESTER, J, POLYCHRONOPOULOS, P, MAGIATIS, P

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Hydrophobic Derivatives of Glycopeptide Antibiotics as Inhibitors of Protein Kinases von Cozza, G., Fortuna, M., Meggio, F., Sarno, S., Kubbutat, M. H. G., Totzke, F., Schaechtele, C., Pinna, L. A., Olsufyeva, E. N., Preobrazhenskaya, M. N.

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413 (PB401): Comprehensive characterization of CDK inhibitors using a complete panel of all 20 human cyclin-dependent kinases von Müller, D., Totzke, F., Weber, T., Krämer, D., Heidemann-Dinger, C., Rademann, C., Torka, R.

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170 A High-throughput Capable Method to Identify Allosteric Inhibitors of Protein Kinase Activation Cascades von Müller, D, Totzke, F, Beisenherz-Huss, C, Heidemann-Dinger, C, Ketterer, C, Krämer, D, Weber, T, Kubbutat, H.G

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173 Analysis of Cellular Kinase Activity of Resistance-related EGFR Mutants Using Transmembrane-Domain (TMD) Activated Kinase Variants von Weber, H, Müller, D, Totzke, F, Müller, M, Siedentopf, O, Kubbutat, M.H.G, Graeser, R, Feger, D, Schaechtele, C, Ehlert, J.E

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Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes von Voigt, Burkhardt, Meijer, Laurent, Lozach, Olivier, Schächtele, Christoph, Totzke, Frank, Hilgeroth, Andreas

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1251 POSTER Preclinical and Clinical Development of 4SC-203 – a Novel Multi-target Kinase Inhibitor von Krauss, R, Wagner, F, Doblhofer, R, Dietrich, B, Ehlert, J, Kubbutat, M.H.G, Lingnau, A, Totzke, F, Schachtele, C, Hentsch, B

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Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 von Schmerwitz, Ulrike K, Sass, Gabriele, Khandoga, Alexander G, Joore, Jos, Mayer, Bettina A, Berberich, Nina, Totzke, Frank, Krombach, Fritz, Tiegs, Gisa, Zahler, Stefan, Vollmar, Angelika M, Fürst, Robert

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PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tum... von WOOD, J. M, BOLD, G, PERSOHN, E, RÖSEL, J, SCHNELL, C, STOVER, D, THEUER, A, TOWBIN, H, WENGER, F, WOODS-COOK, K, MENRAD, A, SIEMEISTER, G, BUCHDUNGER, E, SCHIRNER, M, THIERAUCH, K.-H, SCHNEIDER, M. R, DREVS, J, MARTINY-BARON, G, TOTZKE, F, MARME, D, COZENS, R, FERRARI, S, FREI, J, HOFMANN, F, MESTAN, J, METT, H, O'REILLY, T

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Design, Synthesis, and Biological Evaluation of 3,4-Diarylmaleimides as Angiogenesis Inhibitors von Peifer, Christian, Stoiber, Thomas, Unger, Eberhard, Totzke, Frank, Schächtele, Christoph, Marmé, Dieter, Brenk, Ruth, Klebe, Gerhard, Schollmeyer, Dieter, Dannhardt, Gerd

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Mapping of the Sites for Ligand Binding and Receptor Dimerization at the Extracellular Domain of the Vascular Endothelial Growth Factor Receptor FLT-1 von Barleon, B, Totzke, F, Herzog, C, Blanke, S, Kremmer, E, Siemeister, G, Marmé, D, Martiny-Baron, G

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Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[ b]cycylopenta[ e]aze... von Kunick, Conrad, Bleeker, Carola, Prühs, Christian, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H.G., Link, Andreas

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Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone von Kunick, Conrad, Zeng, Zhihong, Gussio, Rick, Zaharevitz, Daniel, Leost, Maryse, Totzke, Frank, Schächtele, Christoph, Kubbutat, Michael H. G., Meijer, Laurent, Lemcke, Thomas

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Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors von BARLEON, Bernhard, REUSCH, Petra, TOTZKE, Frank, HERZOG, Christel, KECK, Christoph, MARTINY-BARON, Georg, MARME, Dieter

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Diversity-Oriented Synthesis of Pochonins and Biological Evaluation against a Panelof Kinases von Moulin, Emilie, Barluenga, Sofia, Totzke, F., Winssinger, Nicolas

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Anthraquinones and Betaenone Derivatives from the Sponge-Associated Fungus Microsphaeropsis Species:  Novel Inhibitors of Protein Kinases von Brauers, Gernot, Edrada, Ru Angelie, Ebel, Rainer, Proksch, Peter, Wray, Victor, Berg, Albrecht, Gräfe, Udo, Schächtele, Christoph, Totzke, Frank, Finkenzeller, Günter, Marme, Dieter, Kraus, Jürgen, Münchbach, Miriam, Michel, Manuela, Bringmann, Gerhard, Schaumann, Karsten

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Structure-aided optimization of kinase inhibitors derived from alsterpaullone von Kunick, C., Zeng, Z., Gussio, R., Zaharevitz, D., Leost, M., Totzke, F., Schachtele, C., M. H., Kubbutat, Meijer, L., Lemcke, T.

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The Drosophila melanogaster l(2)gl gene encodes a protein homologous to the cadherin cell-adhesion molecule family von Klämbt, Christian, Müller, Stephan, Lützelschwab, Reinhard, Rossa, Rita, Totzke, Frank, Schmidt, Otto

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Over-expression of protein kinase C-α enhances platelet-derived growth factor- and phorbol ester- but not calcium ionophore-induced formation of prostaglandins in NIH 3T3 fibroblas... von Finkenzeller, Günter, Totzke, Frank, Fitzke, Edith, Marmé, Dieter, Dieter, Peter

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