Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor von Zhang, Yong, Parrish, Karen E, Tortolani, David R, Poss, Michael A, Huang, Audris, Wan, Honghe, Purandare, Ashok V, Donnell, Andrew F, Kempson, James, Hou, Xiaoping, Pawluczyk, Joseph, Yip, Shiuhang, Luk, Emily, Raghavan, Nimmi, Swanson, Jesse, Smalley, James, Murtaza, Anwar, Yang, Zheng, Augustine-Rauch, Karen, Lombardo, Louis J, Borzilleri, Robert

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Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-... von Watterson, Scott H, Xiao, Zili, Dodd, Dharmpal S, Tortolani, David R, Vaccaro, Wayne, Potin, Dominique, Launay, Michele, Stetsko, Dawn K, Skala, Stacey, Davis, Patric M, Lee, Deborah, Yang, Xiaoxia, McIntyre, Kim W, Balimane, Praveen, Patel, Karishma, Yang, Zheng, Marathe, Punit, Kadiyala, Pathanjali, Tebben, Andrew J, Sheriff, Steven, Chang, ChiehYing Y, Ziemba, Theresa, Zhang, Huiping, Chen, Bang-Chi, DelMonte, Albert J, Aranibar, Nelly, McKinnon, Murray, Barrish, Joel C, Suchard, Suzanne J, Murali Dhar, T. G

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Two distinct actions of retinoid-receptor ligands von Chen, Jia-Yang, Clifford, John, Zusi, Chris, Starrett, John, Tortolani, David, Ostrowski, Jacek, Reczek, Peter R, Chambon, Pierre, Gronemeyer, Hinrich

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Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design von Gavai, Ashvinikumar V, Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S, Dodd, Dharmpal, O’Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Han, Wen-Ching, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Yan, Chunhong, Marsilio, Frank, Menard, Krista, Wen, Mei-Li, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Traeger, Sarah C, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, Everlof, Gerry, Raghavan, Nirmala, Tye, Ching Kim, Wee, Susan, Hunt, John T, Vite, Gregory, Westhouse, Richard, Lee, Francis Y

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Pyrrolopyridazine MEK inhibitors von Chen, Zhong, Kim, Soong-Hoon, Barbosa, Stephanie A., Huynh, Tram, Tortolani, David R., Leavitt, Kenneth J., Wei, Donna D., Manne, Veeraswamy, Ricca, Carolyn S., Gullo-Brown, Johnni, Poss, Michael A., Vaccaro, Wayne, Salvati, Mark E.

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Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA) von Starrett, John E. Jr, Tortolani, David R, Russell, John, Hitchcock, Michael J. M, Whiterock, Valerie, Martin, John C, Mansuri, Muzammil M

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A Convenient Synthesis to N-Aryl-Substituted 4-Piperidones von Tortolani, David R, Poss, Michael A

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A solid phase synthesis of miconazole analogs via an iodoetherification reaction von Tortolani, David R, Biller, Scott A

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Abstract 5789: Discovery of clinical candidate BMS-986158, an oral BET inhibitor, for the treatment of cancer von Gavai, Ashvinikumar V., Norris, Derek, Tortolani, David, O'Malley, Daniel, Zhao, Yufen, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Dodd, Dharmpal, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Tokarski, John S., Sheriff, Steven, Rampulla, Richard, Wu, Dauh-Rurng, Li, Jianqing, Zhang, Huiping, Li, Peng, Sun, Dawn, Yip, Henry, Zhang, Yingru, Mathur, Arvind, Zhang, Haiying, Huang, Christine, Yang, Zheng, Ranasinghe, Asoka, D'Arienzo, Celia, Su, Ching, Everlof, Gerry, Zhang, Lisa, Raghavan, Nirmala, Hunt, John T., Poss, Michael, Vite, Gregory D., Westhouse, Richard A., Wee, Susan

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Retinoic Acid Receptor β,γ-Selective Ligands: Synthesis and Biological Activity of 6-Substituted 2-Naphthoic Acid Retinoids von Yu, Kuo-Long, Spinazze, Patrick, Ostrowski, Jacek, Currier, Stephen J, Pack, Edward J, Hammer, Laura, Roalsvig, Thor, Honeyman, Jomary A, Tortolani, David R, Reczek, Peter R, Mansuri, Muzammil M, Starrett, John E

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Modulation of cofilin phosphorylation by inhibition of the Lim family kinases von He, Liqi, Seitz, Steven P., Trainor, George L., Tortolani, David, Vaccaro, Wayne, Poss, Michael, Tarby, Christine M., Tokarski, John S., Penhallow, Becky, Hung, Chen-Yi, Attar, Ricardo, Lin, Tai-An

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Rational design of RAR-selective ligands revealed by RARβ crystal stucture von Germain, Pierre, Kammerer, Sabrina, Pérez, Efrén, Peluso-Iltis, Carole, Tortolani, David, Zusi, F Christopher, Starrett, John, Lapointe, Philippe, Daris, Jean-Paul, Marinier, Anne, de Lera, Angel R, Rochel, Natacha, Gronemeyer, Hinrich

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Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine von Starrett, John E., Tortolani, David R., Hitchcock, Michael J.M., Martin, John C., Mansuri, Muzammil M.

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Preparation of 1-(2,3-dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)thymine (d4T) and 2',3'-dideoxyadenosine (ddA): general methods for the synthesis of 2',3'-olefinic and 2',3'-did... von Mansuri, Muzammil M, Starrett, John E, Wos, John A, Tortolani, David R, Brodfuehrer, Paul R, Howell, Henry G, Martin, John C

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Discovery of novel dihydro-9,10-ethano-anthracene carboxamides as glucocorticoid receptor modulators von Yang, Bingwei V., Vaccaro, Wayne, Doweyko, Arthur M., Doweyko, Lidia M., Huynh, Tram, Tortolani, David, Nadler, Steven G., McKay, Lorraine, Somerville, John, Holloway, Deborah A., Habte, Sium, Weinstein, David S., Barrish, Joel C.

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Multiple and Single Binding Modes of Fragment-Like Kinase Inhibitors Revealed by Molecular Modeling, Residue Type-Selective Protonation, and Nuclear Overhauser Effects von Constantine, Keith L, Mueller, Luciano, Metzler, William J, McDonnell, Patricia A, Todderud, Gordon, Goldfarb, Valentina, Fan, Yi, Newitt, John A, Kiefer, Susan E, Gao, Mian, Tortolani, David, Vaccaro, Wayne, Tokarski, John

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IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES von RUAN, Zheming, YANG, Michael G, TORTOLANI, David R, XIAO, Zili

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IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES von Xiao, Zili, Ruan, Zheming, Yang, Michael G, Tortolani, David R

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Aminotriazine 5-HT7 antagonists von MATTSON, Ronald J, DENHART, Derek J, PURANDARE, Ashok, TORTOLANI, David, YUFEN ZHAO, HUA YANG, YEOLA, Suresh, PALMER, Jane, TORRENTE, John, STARK, Arlene, JOHNSON, Graham, CATT, John D, DEE, Michael F, DESKUS, Jeffrey A, DITTA, Jonathan L, EPPERSON, James, KING, H. Dalton, AIMING GAO, POSS, Michael A

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IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES von RUAN, Zheming, YANG, Michael G, TORTOLANI, David R, XIAO, Zili

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