Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects von Baquero, Juan Miguel, Benítez-Buelga, Carlos, Rajagopal, Varshni, Zhenjun, Zhao, Torres-Ruiz, Raúl, Müller, Sarah, Hanna, Bishoy M. F., Loseva, Olga, Wallner, Olov, Michel, Maurice, Rodríguez-Perales, Sandra, Gad, Helge, Visnes, Torkild, Helleday, Thomas, Benítez, Javier, Osorio, Ana

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Modeling mixed-lineage-rearranged leukemia initiation in CD34 + cells: a "CRISPR" solution von Torres-Ruiz, Raúl, Rodriguez-Perales, Sandra, Bueno, Clara, Menendez, Pablo

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CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges von Martinez-Lage, Marta, Puig-Serra, Pilar, Menendez, Pablo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra

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Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling von Oldrini, Barbara, Curiel-García, Álvaro, Marques, Carolina, Matia, Veronica, Uluçkan, Özge, Graña-Castro, Osvaldo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra, Huse, Jason T., Squatrito, Massimo

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Immune Profiling and Quantitative Analysis Decipher the Clinical Role of Immune-Checkpoint Expression in the Tumor Immune Microenvironment of DLBCL von Xu-Monette, Ziju Y, Xiao, Min, Au, Qingyan, Padmanabhan, Raghav, Xu, Bing, Hoe, Nicholas, Rodríguez-Perales, Sandra, Torres-Ruiz, Raul, Manyam, Ganiraju C, Visco, Carlo, Miao, Yi, Tan, Xiaohong, Zhang, Hongwei, Tzankov, Alexandar, Wang, Jing, Dybkær, Karen, Tam, Wayne, You, Hua, Bhagat, Govind, Hsi, Eric D, Ponzoni, Maurilio, Ferreri, Andrés J M, Møller, Michael B, Piris, Miguel A, van Krieken, J Han, Winter, Jane N, Westin, Jason R, Pham, Lan V, Medeiros, L Jeffrey, Rassidakis, George Z, Li, Yong, Freeman, Gordon J, Young, Ken H

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Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL von Lahera, Antonio, Vela-Martín, Laura, López-Nieva, Pilar, Salgado, Rocío N, Rodríguez-Perales, Sandra, Torres-Ruiz, Raúl, López-Lorenzo, José L, Cornago, Javier, Llamas, Pilar, Fernández-Navarro, Pablo, Sánchez-Domínguez, Rebeca, Segovia, José C, Sastre, Isabel, Cobos-Fernández, María Á, Menéndez, Pablo, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis von Brandt, Marta, Grazioso, Tatiana P., Fawal, Mohamad-Ali, Tummala, Krishna S., Torres-Ruiz, Raul, Rodriguez-Perales, Sandra, Perna, Cristian, Djouder, Nabil

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Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia von Tejedor, Juan Ramón, Bueno, Clara, Vinyoles, Meritxell, Petazzi, Paolo, Agraz-Doblas, Antonio, Cobo, Isabel, Torres-Ruiz, Raúl, Bayón, Gustavo F, Pérez, Raúl F, López-Tamargo, Sara, Gutierrez-Agüera, Francisco, Santamarina-Ojeda, Pablo, Ramírez-Orellana, Manuel, Bardini, Michela, Cazzaniga, Giovanni, Ballerini, Paola, Schneider, Pauline, Stam, Ronald W, Varela, Ignacio, Fraga, Mario F, Fernández, Agustín F, Menéndez, Pablo

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Targeting OGG1 arrests cancer cell proliferation by inducing replication stress von Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas

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Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism von García-Silva, Susana, Benito-Martín, Alberto, Nogués, Laura, Hernández-Barranco, Alberto, Mazariegos, Marina S, Santos, Vanesa, Hergueta-Redondo, Marta, Ximénez-Embún, Pilar, Kataru, Raghu P, Lopez, Ana Amor, Merino, Cristina, Sánchez-Redondo, Sara, Graña-Castro, Osvaldo, Matei, Irina, Nicolás-Avila, José Ángel, Torres-Ruiz, Raúl, Rodríguez-Perales, Sandra, Martínez, Lola, Pérez-Martínez, Manuel, Mata, Gadea, Szumera-Ciećkiewicz, Anna, Kalinowska, Iwona, Saltari, Annalisa, Martínez-Gómez, Julia M, Hogan, Sabrina A, Saragovi, H Uri, Ortega, Sagrario, Garcia-Martin, Carmen, Boskovic, Jasminka, Levesque, Mitchell P, Rutkowski, Piotr, Hidalgo, Andrés, Muñoz, Javier, Megías, Diego, Mehrara, Babak J, Lyden, David, Peinado, Héctor

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Efficient Recreation of t(11;22) EWSR1-FLI1+ in Human Stem Cells Using CRISPR/Cas9 von Torres-Ruiz, Raul, Martinez-Lage, Marta, Martin, Maria C., Garcia, Aida, Bueno, Clara, Castaño, Julio, Ramirez, Juan C., Menendez, Pablo, Cigudosa, Juan C., Rodriguez-Perales, Sandra

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Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions von Bueno, Clara, Calero-Nieto, Fernando J, Wang, Xiaonan, Valdés-Mas, Rafael, Gutiérrez-Agüera, Francisco, Roca-Ho, Heleia, Ayllon, Veronica, Real, Pedro J, Arambilet, David, Espinosa, Lluis, Torres-Ruiz, Raul, Agraz-Doblas, Antonio, Varela, Ignacio, de Boer, Jasper, Bigas, Anna, Gottgens, Bertie, Marschalek, Rolf, Menendez, Pablo

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Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress von Martín-Adrados, Beatriz, Wculek, Stefanie K, Fernández-Bravo, Sergio, Torres-Ruiz, Raúl, Valle-Noguera, Ana, Gomez-Sánchez, Maria José, Hernández-Walias, José Carlos, Ferreira, Frederico Moraes, Corraliza, Ana María, Sancho, David, Esteban, Vanesa, Rodriguez-Perales, Sandra, Cruz-Adalia, Aránzazu, Nakaya, Helder I, Salas, Azucena, Bernardo, David, Campos-Martín, Yolanda, Martínez-Zamorano, Elena, Muñoz-López, Diego, Gómez Del Moral, Manuel, Cubero, Francisco Javier, Blumberg, Richard S, Martínez-Naves, Eduardo

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OGG1 Inhibition Triggers Synthetic Lethality and Enhances The Effect of PARP Inhibitor Olaparib in BRCA1-Deficient TNBC Cells von Baquero, Juan Miguel, Marchena-Perea, Erik, Mirabet, Rocío, Torres-Ruiz, Raúl, Blanco-Aparicio, Carmen, Rodríguez-Perales, Sandra, Helleday, Thomas, Benítez-Buelga, Carlos, Benítez, Javier, Osorio, Ana

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Analysis of Telomere Maintenance Related Genes Reveals NOP10 as a New Metastatic-Risk Marker in Pheochromocytoma/Paraganglioma von Monteagudo, María, Martínez, Paula, Leandro-García, Luis J., Martínez-Montes, Ángel M., Calsina, Bruna, Pulgarín-Alfaro, Marta, Díaz-Talavera, Alberto, Mellid, Sara, Letón, Rocío, Gil, Eduardo, Pérez-Martínez, Manuel, Megías, Diego, Torres-Ruiz, Raúl, Rodriguez-Perales, Sandra, González, Patricia, Caleiras, Eduardo, Jiménez-Villa, Scherezade, Roncador, Giovanna, Álvarez-Escolá, Cristina, Regojo, Rita M., Calatayud, María, Guadalix, Sonsoles, Currás-Freixes, Maria, Rapizzi, Elena, Canu, Letizia, Nölting, Svenja, Remde, Hanna, Fassnacht, Martin, Bechmann, Nicole, Eisenhofer, Graeme, Mannelli, Massimo, Beuschlein, Felix, Quinkler, Marcus, Rodríguez-Antona, Cristina, Cascón, Alberto, Blasco, María A., Montero-Conde, Cristina, Robledo, Mercedes

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Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase von Gómez-Morón, Álvaro, Alegre-Gómez, Sergio, Ramirez-Muñoz, Rocio, Hernaiz-Esteban, Alicia, Carrasco-Padilla, Carlos, Scagnetti, Camila, Aguilar-Sopeña, Óscar, García-Gil, Marta, Borroto, Aldo, Torres-Ruiz, Raul, Rodriguez-Perales, Sandra, Sánchez-Madrid, Francisco, Martín-Cófreces, Noa Beatriz, Roda-Navarro, Pedro

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Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency von Muñoz-López, Alvaro, Romero-Moya, Damià, Prieto, Cristina, Ramos-Mejía, Verónica, Agraz-Doblas, Antonio, Varela, Ignacio, Buschbeck, Marcus, Palau, Anna, Carvajal-Vergara, Xonia, Giorgetti, Alessandra, Ford, Anthony, Lako, Majlinda, Granada, Isabel, Ruiz-Xivillé, Neus, Rodríguez-Perales, Sandra, Torres-Ruíz, Raul, Stam, Ronald W., Fuster, Jose Luis, Fraga, Mario F., Nakanishi, Mahito, Cazzaniga, Gianni, Bardini, Michela, Cobo, Isabel, Bayon, Gustavo F., Fernandez, Agustin F., Bueno, Clara, Menendez, Pablo

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Functional characterization of two enhancers located downstream FOXP2 von Torres-Ruiz, Raúl, Benítez-Burraco, Antonio, Martínez-Lage, Marta, Rodríguez-Perales, Sandra, García-Bellido, Paloma

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Detection of chromosome instability by interphase FISH in mouse and human tissues von Torres-Ruiz, Raul, Grazioso, Tatiana P., Brandt, Marta, Martinez-Lage, Marta, Rodriguez-Perales, Sandra, Djouder, Nabil

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RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment von Torres-Gomez, Alvaro, Sanchez-Trincado, Jose Luis, Toribio, Víctor, Torres-Ruiz, Raul, Rodríguez-Perales, Sandra, Yáñez-Mó, María, Reche, Pedro A, Cabañas, Carlos, Lafuente, Esther M

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