Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype von Ivashchenko, Christine Y, Pipes, Gordon C, Lozinskaya, Irina M, Lin, Zuojun, Xiaoping, Xu, Needle, Saul, Grygielko, Eugene T, Hu, Erding, Toomey, John R, Lepore, John J, Willette, Robert N

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Factor Xa Inhibitors:  S1 Binding Interactions of a Series of N-{(3S)-1-[(1S)-1-Methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides von Chan, Chuen, Borthwick, Alan D, Brown, David, Burns-Kurtis, Cynthia L, Campbell, Matthew, Chaudry, Laiq, Chung, Chun-wa, Convery, Máire A, Hamblin, J. Nicole, Johnstone, Lisa, Kelly, Henry A, Kleanthous, Savvas, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Senger, Stefan, Shah, Gita P, Toomey, John R, Watson, Nigel S, Weston, Helen E, Whitworth, Caroline, Young, Robert J, Zhou, Ping

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Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function von Erhardt, Joseph A, Erickson-Miller, Connie L, Aivado, Manuel, Abboud, Melanie, Pillarisetti, Kodandaram, Toomey, John R

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Antithrombotic Efficacy of a Novel Murine Antihuman Factor IX Antibody in Rats von Feuerstein, Giora Z, Patel, Arun, Toomey, John R, Bugelski, Peter, Nichols, Andrew J, Church, William R, Valocik, Richard, Koster, Paul, Baker, Audrey, Blackburn, Michael N

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High FGF23 Levels Failed to Predict Cardiac Hypertrophy in Animal Models of Hyperphosphatemia and Chronic Renal Failure von Moench, Ian, Aravindhan, Karpagam, Kuziw, Joanne, Schnackenberg, Christine G, Willette, Robert N, Toomey, John R, Gatto, Gregory J

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Effect of Tissue Factor Deficiency on Mouse and Tumor Development von Toomey, John R., Kratzer, Kenneth E., Lasky, Nina M., Broze, George J.

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The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa von Aktimur, Aysar, Gabriel, Melanie A, Gailani, David, Toomey, John R

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The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs von Watson, Nigel S., Adams, Carl, Belton, David, Brown, David, Burns-Kurtis, Cynthia L., Chaudry, Laiq, Chan, Chuen, Convery, Máire A., Davies, David E., Exall, Anne M., Harling, John D., Irvine, Stephanie, Irving, Wendy R., Kleanthous, Savvas, McLay, Iain M., Pateman, Anthony J., Patikis, Angela N., Roethke, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.

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Reconsidering phenotypic heart failure drug discovery von Toomey, John R, Upson, John J

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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs von Young, Robert J., Adams, Carl, Blows, Mike, Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Chaudry, Laiq, Convery, Máire A., Davies, David E., Exall, Anne M., Foster, Graham, Harling, John D., Hortense, Eric, Irvine, Stephanie, Irving, Wendy R., Jackson, Steve, Kleanthous, Savvas, Pateman, Anthony J., Patikis, Angela N., Roethka, Theresa J., Senger, Stefan, Stelman, Gary J., Toomey, John R., West, Robert I., Whittaker, Caroline, Zhou, Ping, Watson, Nigel S.

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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs von Kleanthous, Savvas, Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chaudry, Laiq, Chan, Chuen, Clarte, Marie-Olive, Convery, Máire A., Harling, John D., Hortense, Eric, Irving, Wendy R., Irvine, Stephanie, Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Roethka, Theresa J., Senger, Stefan, Shah, Gita P., Stelman, Gary J., Toomey, John R., Watson, Nigel S., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.

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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs von Young, Robert J., Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chan, Chuen, Charbaut, Marie, Chung, Chun-wa, Convery, Máire A., Kelly, Henry A., Paul King, N., Kleanthous, Savvas, Mason, Andrew M., Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Weston, Helen E.

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Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs von Young, Robert J., Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chan, Chuen, Charbaut, Marie, Convery, Máire A., Diallo, Hawa, Hortense, Eric, Irving, Wendy R., Kelly, Henry A., King, N. Paul, Kleanthous, Savvas, Mason, Andrew M., Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Weston, Helen E., Zhou, Ping

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Selective and dual action orally active inhibitors of thrombin and factor Xa von Young, Robert J., Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Convery, Máire A., Hubbard, Julia A., Kelly, Henry A., Pateman, Anthony J., Patikis, Angela, Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Zhou, Ping

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Inhibition of factor IX(a) is protective in a rat model of thromboembolic stroke von TOOMEY, John R, VALOCIK, Richard E, KOSTER, Paul F, GABRIEL, Melanie A, MCVEY, Matt, HART, Timothy K, OHLSTEIN, Eliot H, PARSONS, Andrew A, BARONE, Frank C

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Antithrombotic Potential of GW813893: A Novel, Orally Active, Active-site Directed Factor Xa Inhibitor von Abboud, Melanie A, Needle, Saul J, Burns-Kurtis, Cynthia L, Valocik, Richard E, Koster, Paul F, Amour, Augustin J, Chan, Chuen, Brown, David, Chaudry, Laiq, Zhou, Ping, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Young, Rob J, Watson, Nigel S, Toomey, John R

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Comparing the Antithrombotic Efficacy of a Humanized Anti-factor IX(a) Monoclonal Antibody (SB 249417) to the Low Molecular Weight Heparin Enoxaparin In a Rat Model of Arterial Thr... von Toomey, John R, Blackburn, Michael N, Storer, Barbara L, Valocik, Richard E, Koster, Paul F, Feuerstein, Giora Z

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Activation of Caspase-3/Caspase-3-Like Activity in Rat Cardiomyocytes by an RGD Peptide, but not the GPIIb/IIIa Antagonist Lotrafiban von Erhardt, Joseph A., Ohlstein, Eliot H., Toomey, John R., Gabriel, Melanie A., Willette, Robert N., Yue, Tian-Li, Barone, Frank C., Parsons, Andrew A.

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Receptor-mediated Endocytosis of Coagulation Factor Xa Requires Cell Surface-bound Tissue Factor Pathway Inhibitor (∗) von Ho, Guyu, Toomey, John R., Broze, George J. Jr, Schwartz, Alan L.

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Targeted disruption of the murine tissue factor gene results in embryonic lethality von TOOMEY, J. R, KRATZER, K. E, LASKY, N. M, STANTON, J. J, BROZE, G. J

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