Inhibition of Protein−Protein Association by Small Molecules:  Approaches and Progress von Toogood, Peter L

Volltext

Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts von Fry, David W, Harvey, Patricia J, Keller, Paul R, Elliott, William L, Meade, Maryanne, Trachet, Erin, Albassam, Mudher, Zheng, XianXian, Leopold, Wilbur R, Pryer, Nancy K, Toogood, Peter L

Volltext

Synthesis of (−)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates von Ruble, J. Craig, Hurd, Alexander R, Johnson, Timothy A, Sherry, Debra A, Barbachyn, Michael R, Toogood, Peter L, Bundy, Gordon L, Graber, David R, Kamilar, Gregg M

Volltext

Discovery of a Potent and Selective Inhibitor of Cyclin-Dependent Kinase 4/6 von Toogood, Peter L, Harvey, Patricia J, Repine, Joseph T, Sheehan, Derek J, VanderWel, Scott N, Zhou, Hairong, Keller, Paul R, McNamara, Dennis J, Sherry, Debra, Zhu, Tong, Brodfuehrer, Joanne, Choi, Chung, Barvian, Mark R, Fry, David W

Volltext

Small molecule immuno-oncology therapeutic agents von Toogood, Peter L.

Volltext

A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model von Menu, Eline, Garcia, Josefina, Huang, Xiangao, Di Liberto, Maurizio, Toogood, Peter L, Chen, Isan, Vanderkerken, Karin, Chen-Kiang, Selina

Volltext

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6 von BAUGHN, Linda B, DI LIBERTO, Maurizio, CHEN-KIANG, Selina, KAIDA WU, TOOGOOD, Peter L, LOUIE, Tracey, GOTTSCHALK, Rachel, NIESVIZKY, Ruben, CHO, Hearn, ELY, Scott, MOORE, Malcolm A. S

Volltext

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from? von Toogood, Peter L., Clauw, Daniel J., Phadke, Sameer, Hoffman, David

Volltext

Sterol metabolism controls T(H)17 differentiation by generating endogenous RORγ agonists von Hu, Xiao, Wang, Yahong, Hao, Ling-Yang, Liu, Xikui, Lesch, Chuck A, Sanchez, Brian M, Wendling, Jay M, Morgan, Rodney W, Aicher, Tom D, Carter, Laura L, Toogood, Peter L, Glick, Gary D

Volltext

Cyclin-dependent kinase inhibitors for treating cancer von Toogood, Peter L.

Volltext

Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists von Hu, Xiao, Wang, Yahong, Hao, Ling-Yang, Liu, Xikui, Lesch, Chuck A, Sanchez, Brian M, Wendling, Jay M, Morgan, Rodney W, Aicher, Tom D, Carter, Laura L, Toogood, Peter L, Glick, Gary D

Volltext

Mitochondrial drugs von Toogood, Peter L

Volltext

COVID-19: Living through Another Pandemic von Osman, Essam Eldin A, Toogood, Peter L, Neamati, Nouri

Volltext

Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ) Agonist for Use in Treating Cancer von Aicher, Thomas D, Van Huis, Chad A, Hurd, Alexander R, Skalitzky, Donald J, Taylor, Clarke B, Beleh, Omar M, Glick, Gary, Toogood, Peter L, Yang, Bing, Zheng, Tao, Huo, Changxin, Gao, Jie, Qiao, Chenxi, Tian, Xiaolong, Zhang, Junping, Demock, Kellie, Hao, Ling-Yang, Lesch, Charles A, Morgan, Rodney W, Moisan, Jacques, Wang, Yahong, Scatina, JoAnn, Paulos, Chrystal M, Zou, Weiping, Carter, Laura L, Hu, Xiao

Volltext

Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity von Hu, Xiao, Liu, Xikui, Moisan, Jacques, Wang, Yahong, Lesch, Charles A., Spooner, Chauncey, Morgan, Rodney W., Zawidzka, Elizabeth M., Mertz, David, Bousley, Dick, Majchrzak, Kinga, Kryczek, Ilona, Taylor, Clarke, Van Huis, Chad, Skalitzky, Don, Hurd, Alexander, Aicher, Thomas D., Toogood, Peter L., Glick, Gary D., Paulos, Chrystal M., Zou, Weiping, Carter, Laura L.

Volltext

A Short and Efficient Synthesis of l-5,5,5,5‘,5‘,5‘-hexafluoroleucine from N-Cbz-l-Serine von Anderson, James T, Toogood, Peter L, Marsh, E. Neil G

Volltext

Pyrido[2,3-d]pyrimidin-7-ones as Specific Inhibitors of Cyclin-Dependent Kinase 4 von VanderWel, Scott N, Harvey, Patricia J, McNamara, Dennis J, Repine, Joseph T, Keller, Paul R, Quin, John, Booth, R. John, Elliott, William L, Dobrusin, Ellen M, Fry, David W, Toogood, Peter L

Volltext

Progress toward the development of agents to modulate the cell cycle von Toogood, Peter L

Volltext

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase von Montgomery, Justin I., Toogood, Peter L., Hutchings, Kim M., Liu, Jia, Narasimhan, Lakshmi, Braden, Timothy, Dermyer, Michael R., Kulynych, Angela D., Smith, Yvonne D., Warmus, Joseph S., Taylor, Clarke

Volltext

2-Aminoquinazoline inhibitors of cyclin-dependent kinases von Bathini, Yadagiri, Singh, Inderjit, Harvey, Patricia J., Keller, Paul R., Singh, Rajeshwar, Micetich, Ronald G., Fry, David W., Dobrusin, Ellen M., Toogood, Peter L.

Volltext