Rational design of a new antibiotic class for drug-resistant infections von Durand-Reville, Thomas F., Miller, Alita A., O’Donnell, John P., Wu, Xiaoyun, Sylvester, Mark A., Guler, Satenig, Iyer, Ramkumar, Shapiro, Adam B., Carter, Nicole M., Velez-Vega, Camilo, Moussa, Samir H., McLeod, Sarah M., Chen, April, Tanudra, Angela M., Zhang, Jing, Comita-Prevoir, Janelle, Romero, Jan A., Huynh, Hoan, Ferguson, Andrew D., Horanyi, Peter S., Mayclin, Stephen J., Heine, Henry S., Drusano, George L., Cummings, Jason E., Slayden, Richard A., Tommasi, Ruben A.

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Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β‑Lactamases von Durand-Réville, Thomas F, Comita-Prevoir, Janelle, Zhang, Jing, Wu, Xiaoyun, May-Dracka, Tricia L, Romero, Jan Antoinette C, Wu, Frank, Chen, April, Shapiro, Adam B, Carter, Nicole M, McLeod, Sarah M, Giacobbe, Robert A, Verheijen, Jeroen C, Lahiri, Sushmita D, Sacco, Michael D, Chen, Yu, O’Donnell, John P, Miller, Alita A, Mueller, John P, Tommasi, Rubén A

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Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class von Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit

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ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii von Durand-Réville, Thomas F., Guler, Satenig, Comita-Prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B., McLeod, Sarah M., Carter, Nicole M., Moussa, Samir H., Velez-Vega, Camilo, Olivier, Nelson B., McLaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A., Newman, Joseph V., Ehmann, David E., de Jonge, Boudewijn, O'Donnell, John, Mueller, John P., Tommasi, Rubén A., Miller, Alita A.

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Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors von Whitehead, Lewis, Dobler, Markus R., Radetich, Branko, Zhu, Yanyi, Atadja, Peter W., Claiborne, Tavina, Grob, Jonathan E., McRiner, Andrew, Pancost, Margaret R., Patnaik, Anup, Shao, Wenlin, Shultz, Michael, Tichkule, Ritesh, Tommasi, Ruben A., Vash, Brian, Wang, Ping, Stams, Travis

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Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design von Greenspan, Paul D, Clark, Kirk L, Tommasi, Ruben A, Cowen, Scott D, McQuire, Leslie W, Farley, David L, van Duzer, John H, Goldberg, Ronald L, Zhou, Huanghai, Du, Zhengming, Fitt, John J, Coppa, David E, Fang, Zheng, Macchia, William, Zhu, Lijuan, Capparelli, Michael P, Goldstein, Robert, Wigg, Andrew M, Doughty, John R, Bohacek, Regine S, Knap, Ania K

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N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay von Furuya, Takeru, Shapiro, Adam B., Comita-Prevoir, Janelle, Kuenstner, Eric J., Zhang, Jing, Ribe, Seth D., Chen, April, Hines, Daniel, Moussa, Samir H., Carter, Nicole M., Sylvester, Mark A., Romero, Jan A.C., Vega, Camilo V., Sacco, Michael D., Chen, Yu, O'Donnell, John P., Durand-Reville, Thomas F., Miller, Alita A., Tommasi, Ruben A.

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Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 von Monovich, Lauren G, Tommasi, Ruben A, Fujimoto, Roger A, Blancuzzi, Vincent, Clark, Kirk, Cornell, Wendy D, Doti, Robert, Doughty, John, Fang, James, Farley, David, Fitt, John, Ganu, Vishwas, Goldberg, Ronald, Goldstein, Robert, Lavoie, Stacey, Kulathila, Raviraj, Macchia, William, Parker, David T, Melton, Richard, O’Byrne, Elizabeth, Pastor, Gary, Pellas, Theodore, Quadros, Elizabeth, Reel, Noela, Roland, Dennis M, Sakane, Yumi, Singh, Hem, Skiles, Jerry, Somers, Joseph, Toscano, Karen, Wigg, Andrew, Zhou, Siyuan, Zhu, Lijuan, Shieh, Wen-Chung, Xue, Song, McQuire, Leslie W

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Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13 von Tommasi, Ruben A., Weiler, Sven, McQuire, Leslie W., Rogel, Olivier, Chambers, Mark, Clark, Kirk, Doughty, John, Fang, James, Ganu, Vishwas, Grob, Jonathan, Goldberg, Ronald, Goldstein, Robert, LaVoie, Stacey, Kulathila, Raviraj, Macchia, William, Melton, Richard, Springer, Clayton, Walker, Marc, Zhang, Jing, Zhu, Lijuan, Shultz, Michael

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N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B von Greenspan, Paul D., Clark, Kirk L., Cowen, Scott D., McQuire, Leslie W., Tommasi, Ruben A., Farley, David L., Quadros, Elizabeth, Coppa, David E., Du, Zengming, Fang, Zheng, Zhou, Huanghai, Doughty, John, Toscano, Karen T., Wigg, Andrew M., Zhou, Siyuan

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Structure-Based Design of HIV Protease Inhibitors:  Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors von Thaisrivongs, Suvit, Skulnick, Harvey I, Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Johnson, Paul D, Aristoff, Paul A, Judge, Thomas M, Gammill, Ronald B, Morris, Jeanette K, Romines, Karen R, Chrusciel, Robert A, Hinshaw, Roger R, Chong, Kong-Teck, Tarpley, W. Gary, Poppe, Susan M, Slade, David E, Lynn, Janet C, Horng, Miao-Miao, Tomich, Paul K, Seest, Eric P, Dolak, Lester A, Howe, W. Jeffrey, Howard, Gina M, Schwende, Francis J, Toth, Lisa N, Padbury, Guy E, Wilson, Grace J, Shiou, Lihua, Zipp, Gail L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J, Koeplinger, Kenneth A, Zhao, Zhiyang, Cole, Serena, Zaya, Renee M, Kakuk, Thomas J, Janakiraman, Musiri N, Watenpaugh, Keith D

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones von JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W

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Novel synthesis of heterocyclic aryl amidines von Tommasi, Ruben A, Macchia, William M, Parker, David T

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Total synthesis of (-)-(9R)-7,11-dideoxy-13-deoxodaunomycinone von Hauser, Frank M, Tommasi, Ruben A

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Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors von Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D

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Immobilizations of Nucleophiles on Polystyrene Supports von Brill, Wolfgang K.-D., Schmidt, Erika, Tommasi, Ruben A.

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Non-peptidic HIV protease inhibitors: C 2-symmetry-based design of bis-sulfonamide dihydropyrones von Janakiraman, Musiri N., Watenpaugh, Keith D., Tomich, Paul K., Chong, Kong-Teck, Turner, Steve R., Tommasi, Ruben A., Thaisrivongs, Suvit, Strohbach, Joseph W.

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Covalent or trapped? PFG diffusion MAS NMR for combinatorial chemistry von Shapiro, Michael J., Chin, Jefferson, Chen, Aidi, Wareing, James R., Tang, Qing, Tommasi, Ruben A., Marepalli, Hanumantha R.

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ETX2514 is a broad-spectrum [beta]-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii von Durand-réville, Thomas F, Guler, Satenig, Comita-prevoir, Janelle, Chen, Brendan, Bifulco, Neil, Huynh, Hoan, Lahiri, Sushmita, Shapiro, Adam B, Mcleod, Sarah M, Carter, Nicole M, Moussa, Samir H, Velez-vega, Camilo, Olivier, Nelson B, Mclaughlin, Robert, Gao, Ning, Thresher, Jason, Palmer, Tiffany, Andrews, Beth, Giacobbe, Robert A, Newman, Joseph V, Ehmann, David E, De Jonge, Boudewijn, O'donnell, John, Mueller, John P, Tommasi, Rubén A, Miller, Alita A

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Novel method for the loading of nucleophiles on multipin crowns von Tommasi, Ruben A., Nantermet, Philippe G., Shapiro, Michael J., Chin, Jefferson, Brill, Wolfgang K.-D., Ang, Kiah

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