Formation of Heterocyclic and Polycyclic Compounds from Amino Alcohols and Dialdehydes von Peera, Asghar A., Tomlinson, Ian A.

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Transformer-based biomarker prediction from colorectal cancer histology: A large-scale multicentric study von Wagner, Sophia J., Reisenbüchler, Daniel, West, Nicholas P., Niehues, Jan Moritz, Zhu, Jiefu, Foersch, Sebastian, Veldhuizen, Gregory Patrick, Quirke, Philip, Grabsch, Heike I., van den Brandt, Piet A., Hutchins, Gordon G.A., Richman, Susan D., Yuan, Tanwei, Langer, Rupert, Jenniskens, Josien C.A., Offermans, Kelly, Mueller, Wolfram, Gray, Richard, Gruber, Stephen B., Greenson, Joel K., Rennert, Gad, Bonner, Joseph D., Schmolze, Daniel, Jonnagaddala, Jitendra, Hawkins, Nicholas J., Ward, Robyn L., Morton, Dion, Seymour, Matthew, Magill, Laura, Nowak, Marta, Hay, Jennifer, Koelzer, Viktor H., Church, David N., Church, David, Domingo, Enric, Edwards, Joanne, Glimelius, Bengt, Gogenur, Ismail, Harkin, Andrea, Hay, Jen, Iveson, Timothy, Jaeger, Emma, Kelly, Caroline, Kerr, Rachel, Maka, Noori, Morgan, Hannah, Oien, Karin, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Sansom, Owen, Saunders, Mark, Tomlinson, Ian, Matek, Christian, Geppert, Carol, Peng, Chaolong, Zhi, Cheng, Ouyang, Xiaoming, James, Jacqueline A., Loughrey, Maurice B., Salto-Tellez, Manuel, Brenner, Hermann, Hoffmeister, Michael, Truhn, Daniel, Schnabel, Julia A., Boxberg, Melanie, Peng, Tingying, Kather, Jakob Nikolas

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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis von Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.

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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas von Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M, Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Guarino, Estrella, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher C, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J, Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw J W, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

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Risk factors for the development of invasive cancer in unresected ductal carcinoma in situ von Maxwell, Anthony J., Clements, Karen, Hilton, Bridget, Dodwell, David J., Evans, Andrew, Kearins, Olive, Pinder, Sarah E., Thomas, Jeremy, Wallis, Matthew G., Thompson, Alastair M., Thompson, Alastair, Clements, Karen, Dobson, Hilary, Dodwell, David, Evans, Andrew, Hanby, Andrew, Hilton, Bridget, Kearins, Olive, Lawrence, Gill, Maxwell, Anthony, Pinder, Sarah, Sawyer, Elinor, Sibbering, Mark, Speirs, Valerie, Thomas, Jeremy, Tomlinson, Ian, Ball, Graham, Wallis, Matthew, Wilcox, Maggie

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Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project von Thompson, Alastair M., Clements, Karen, Cheung, Shan, Pinder, Sarah E., Lawrence, Gill, Sawyer, Elinor, Kearins, Olive, Ball, Graham R., Tomlinson, Ian, Hanby, Andrew, Thomas, Jeremy St J., Maxwell, Anthony J., Wallis, Matthew G., Dodwell, David J., Thompson, Alastair, Francis, Adele, Sibbering, Mark, Bishop, Hugh, Carpenter, Robert, George, W.D., Lee, Martin, Nicholson, Stewart, Dobson, Hilary, Evans, Andy, Maxwell, Anthony, Wallis, Matthew, Dodwell, David, Sawyer, Elinor, Adlard, Julian, Dewar, John, Ross, Gillian, Wilcox, Maggie, Hanby, Andrew, Pinder, Sarah, Speirs, Valerie, Thomas, Jeremy, Ellis, Ian, Lakhani, Sunil, Macartney, James, Tomlinson, Ian, Cheung, Shan, Lawrence, Gill, Ball, Graham, Clements, Karen, Hilton, Bridget, Kearins, Olive, Wheaton, Margot

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Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database von Thompson, Bryony A, Spurdle, Amanda B, Plazzer, John-Paul, Greenblatt, Marc S, Akagi, Kiwamu, Al-Mulla, Fahd, Bapat, Bharati, Bernstein, Inge, Capellá, Gabriel, den Dunnen, Johan T, du Sart, Desiree, Fabre, Aurelie, Farrell, Michael P, Farrington, Susan M, Frayling, Ian M, Frebourg, Thierry, Goldgar, David E, Heinen, Christopher D, Holinski-Feder, Elke, Kohonen-Corish, Maija, Robinson, Kristina Lagerstedt, Leung, Suet Yi, Martins, Alexandra, Moller, Pal, Morak, Monika, Nystrom, Minna, Peltomaki, Paivi, Pineda, Marta, Qi, Ming, Ramesar, Rajkumar, Rasmussen, Lene Juel, Royer-Pokora, Brigitte, Scott, Rodney J, Sijmons, Rolf, Tavtigian, Sean V, Tops, Carli M, Weber, Thomas, Wijnen, Juul, Woods, Michael O, Macrae, Finlay, Genuardi, Maurizio

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Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden von Cazier, J. -B., Rao, S. R., McLean, C. M., Walker, A. K., Wright, B. J., Jaeger, E. E. M., Kartsonaki, C., Marsden, L., Yau, C., Camps, C., Kaisaki, P., Taylor, J., Catto, J. W., Tomlinson, I. P. M., Kiltie, A. E., Hamdy, F. C.

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Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers von Zhang, Yan Dora, Hurson, Amber N., Zhang, Haoyu, Choudhury, Parichoy Pal, Easton, Douglas F., Milne, Roger L., Simard, Jacques, Hall, Per, Michailidou, Kyriaki, Dennis, Joe, Schmidt, Marjanka K., Chang-Claude, Jenny, Gharahkhani, Puya, Whiteman, David, Campbell, Peter T., Hoffmeister, Michael, Jenkins, Mark, Peters, Ulrike, Hsu, Li, Gruber, Stephen B., Casey, Graham, Schmit, Stephanie L., O’Mara, Tracy A., Spurdle, Amanda B., Thompson, Deborah J., Tomlinson, Ian, De Vivo, Immaculata, Landi, Maria Teresa, Law, Matthew H., Iles, Mark M., Demenais, Florence, Kumar, Rajiv, MacGregor, Stuart, Bishop, D. Timothy, Ward, Sarah V., Bondy, Melissa L., Houlston, Richard, Wiencke, John K., Melin, Beatrice, Barnholtz-Sloan, Jill, Kinnersley, Ben, Wrensch, Margaret R., Amos, Christopher I., Hung, Rayjean J., Brennan, Paul, McKay, James, Caporaso, Neil E., Berndt, Sonja I., Birmann, Brenda M., Camp, Nicola J., Kraft, Peter, Rothman, Nathaniel, Slager, Susan L., Berchuck, Andrew, Pharoah, Paul D. P., Sellers, Thomas A., Gayther, Simon A., Pearce, Celeste L., Goode, Ellen L., Schildkraut, Joellen M., Moysich, Kirsten B., Amundadottir, Laufey T., Jacobs, Eric J., Klein, Alison P., Petersen, Gloria M., Risch, Harvey A., Stolzenberg-Solomon, Rachel Z., Wolpin, Brian M., Li, Donghui, Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Al Olama, Ali Amin, Purdue, Mark P., Scelo, Ghislaine, Dalgaard, Marlene D., Greene, Mark H., Grotmol, Tom, Kanetsky, Peter A., McGlynn, Katherine A., Nathanson, Katherine L., Turnbull, Clare, Wiklund, Fredrik, Chanock, Stephen J., Chatterjee, Nilanjan, Garcia-Closas, Montserrat

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Signatures of TOP1 transcription-associated mutagenesis in cancer and germline von Reijns, Martin A. M., Parry, David A., Williams, Thomas C., Nadeu, Ferran, Hindshaw, Rebecca L., Rios Szwed, Diana O., Nicholson, Michael D., Carroll, Paula, Boyle, Shelagh, Royo, Romina, Cornish, Alex J., Xiang, Hang, Ridout, Kate, Schuh, Anna, Aden, Konrad, Palles, Claire, Campo, Elias, Stankovic, Tatjana, Taylor, Martin S., Jackson, Andrew P.

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The evolutionary landscape of colorectal tumorigenesis von Cross, William, Kovac, Michal, Mustonen, Ville, Temko, Daniel, Davis, Hayley, Baker, Ann-Marie, Biswas, Sujata, Arnold, Roland, Chegwidden, Laura, Gatenbee, Chandler, Anderson, Alexander R., Koelzer, Viktor H., Martinez, Pierre, Jiang, Xiaowei, Domingo, Enric, Woodcock, Dan J., Feng, Yun, Kovacova, Monika, Maughan, Tim, Jansen, Marnix, Rodriguez-Justo, Manuel, Ashraf, Shazad, Guy, Richard, Cunningham, Christopher, East, James E., Wedge, David C., Wang, Lai Mun, Palles, Claire, Heinimann, Karl, Sottoriva, Andrea, Leedham, Simon J., Graham, Trevor A., Tomlinson, Ian P. M.

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Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis von Frei, Anja L, McGuigan, Anthony, Sinha, Ritik R A K, Jabbar, Faiz, Gneo, Luciana, Tomasevic, Tijana, Harkin, Andrea, Iveson, Tim, Saunders, Mark P, Oien, Karin A, Maka, Noori, Pezzella, Francesco, Campo, Leticia, Browne, Molly, Glaire, Mark, Kildal, Wanja, Danielsen, Havard E, Hay, Jennifer, Edwards, Joanne, Sansom, Owen, Kelly, Caroline, Tomlinson, Ian, Kerr, Rachel, Kerr, David, Domingo, Enric, Church, David N, Domingo, Enric, Edwards, Joanne, Glimelius, Bengt, Gonegur, Ismail, Harkin, Andrea, Hay, Jen, Iveson, Timothy, Jaeger, Emma, Kelly, Caroline, Kerr, Rachel, Maka, Noori, Morgan, Hannah, Oien, Karen, Orange, Clare, Palles, Claire, Roxburgh, Campbell, Sansom, Owen, Saunders, Mark P, Tomlinson, Ian, Church, David N, Koelzer, Viktor H

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Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis von Sharma, Vikram P, Fenwick, Aimée L, Brockop, Mia S, McGowan, Simon J, Goos, Jacqueline A C, Hoogeboom, A Jeannette M, Brady, Angela F, Jeelani, Nu Owase, Lynch, Sally Ann, Mulliken, John B, Murray, Dylan J, Phipps, Julie M, Sweeney, Elizabeth, Tomkins, Susan E, Wilson, Louise C, Bennett, Sophia, Cornall, Richard J, Broxholme, John, Kanapin, Alexander, Johnson, David, Wall, Steven A, van der Spek, Peter J, Mathijssen, Irene M J, Maxson, Robert E, Twigg, Stephen R F, Wilkie, Andrew O M

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Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis von Schoenpflug, Lydia A, Chatzipli, Aikaterini, Sirinukunwattana, Korsuk, Richman, Susan, Blake, Andrew, Robineau, James, Mertz, Kirsten D, Verrill, Clare, Leedham, Simon J, Hardy, Claire, Whalley, Celina, Redmond, Keara, Dunne, Philip, Walker, Steven, Beggs, Andrew D, McDermott, Ultan, Murray, Graeme I, Samuel, Leslie M, Seymour, Matthew, Tomlinson, Ian, Quirke, Philip, Rittscher, Jens, Maughan, Tim, Domingo, Enric, Koelzer, Viktor H

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Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer von Elsayed, Fadwa A., Grolleman, Judith E., Ragunathan, Abiramy, Boot, Arnoud, Stojovska, Marija Staninova, Mahmood, Khalid, Clendenning, Mark, de Miranda, Noel, Dymerska, Dagmara, Egmond, Demi van, Gallinger, Steven, Georgeson, Peter, Hoogerbrugge, Nicoline, Hopper, John L., Jansen, Erik A.M., Jenkins, Mark A., Joo, Jihoon E., Kuiper, Roland P., Ligtenberg, Marjolijn J.L., Lubinski, Jan, Macrae, Finlay A., Morreau, Hans, Newcomb, Polly, Nielsen, Maartje, Palles, Claire, Park, Daniel J., Pope, Bernard J., Rosty, Christophe, Ruiz Ponte, Clara, Schackert, Hans K., Sijmons, Rolf H., Tomlinson, Ian P., Tops, Carli M.J., Vreede, Lilian, Walker, Romy, Win, Aung K., Buchanan, Daniel D., van Wezel, Tom, de Voer, Richarda M.

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Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders von van Schouwenburg, Pauline A, Davenport, Emma E, Kienzler, Anne-Kathrin, Marwah, Ishita, Wright, Benjamin, Lucas, Mary, Malinauskas, Tomas, Martin, Hilary C, Lockstone, Helen E, Cazier, Jean-Baptiste, Chapel, Helen M, Knight, Julian C, Patel, Smita Y

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Congenital myasthenic syndromes due to mutations in ALG2 and ALG14 von COSSINS, Judith, BELAYA, Katsiaryna, LAVAL, Steven, ZAIN SEIDHAMED, Mohammed, DONNELLY, Peter, BENTLEY, David, MCGOWAN, Simon J, MÜLLER, Juliane, PALACE, Jacqueline, LOCHMÜLLER, Hanns, BEESON, David, HICKS, Debbie, SALIH, Mustafa A, FINLAYSON, Sarah, CARBONI, Nicola, WEI WEI LIU, MAXWELL, Susan, ZOLTOWSKA, Katarzyna, TORABI FARSANI, Golara

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Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability von Twigg, Stephen R.F., Forecki, Jennifer, Goos, Jacqueline A.C., Richardson, Ivy C.A., Hoogeboom, A. Jeannette M., van den Ouweland, Ans M.W., Swagemakers, Sigrid M.A., Lequin, Maarten H., Van Antwerp, Daniel, McGowan, Simon J., Westbury, Isabelle, Miller, Kerry A., Wall, Steven A., van der Spek, Peter J., Mathijssen, Irene M.J., Pauws, Erwin, Merzdorf, Christa S., Wilkie, Andrew O.M.

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Publisher Correction: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline von Reijns, Martin A. M., Parry, David A., Williams, Thomas C., Nadeu, Ferran, Hindshaw, Rebecca L., Rios Szwed, Diana O., Nicholson, Michael D., Carroll, Paula, Boyle, Shelagh, Royo, Romina, Cornish, Alex J., Xiang, Hang, Ridout, Kate, Schuh, Anna, Aden, Konrad, Palles, Claire, Campo, Elias, Stankovic, Tatjana, Taylor, Martin S., Jackson, Andrew P.

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Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I von Babbs, C., Roberts, N. A., Sanchez-Pulido, L., McGowan, S. J., Ahmed, M. R., Brown, J. M., Sabry, M. A., Bentley, D. R., McVean, G. A., Donnelly, P., Gileadi, O., Ponting, C. P., Higgs, D. R., Buckle, V. J.

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