Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors von Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

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Structure-Based Design of Novel HIV Protease Inhibitors:  Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors von Thaisrivongs, Suvit, Janakiraman, Musiri N, Chong, Kong-Teck, Tomich, Paul K, Dolak, Lester A, Turner, Steve R, Strohbach, Joseph W, Lynn, Janet C, Horng, Miao-Miao, Hinshaw, Roger R, Watenpaugh, Keith D

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Structure-Based Design of HIV Protease Inhibitors:  5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors von Thaisrivongs, Suvit, Romero, Donna L, Tommasi, Ruben A, Janakiraman, Musiri N, Strohbach, Joseph W, Turner, Steve R, Biles, Carolyn, Morge, Raymond R, Johnson, Paul D, Aristoff, Paul A, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Howe, W. Jeffrey, Finzel, Barry C, Watenpaugh, Keith D

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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors von Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

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Streptomyces cloning: useful recombinant DNA systems and a summation of cloned genes von TOMICH, P. K

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure von Romines, Karen R, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Lovasz, Kristine D, Morris, Jeanette K, Janakiraman, Musiri N, Lynn, Janet C, Horng, Miao-Miao

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Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917 von Clewell, D B, Tomich, P K, Gawron-Burke, M C, Franke, A E, Yagi, Y, An, F Y

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Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis von Tomich, P K, An, F Y, Clewell, D B

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Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors:  Exploring the Impact of Ring Size on Structure−Activity Relationships von Romines, Karen R, Morris, Jeanette K, Howe, W. Jeffrey, Tomich, Paul K, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Anderson, David J, Strohbach, Joseph W, Turner, Steve R, Mizsak, Steve A

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3-arylpiperidines as potentiators of existing antibacterial agents von THORARENSEN, Atli, PRESLEY-BODNAR, Alice L, MAROTTI, Keith R, BOYLE, Timothy P, HECKAMAN, Charlotte L, BOHANON, Michael J, TOMICH, Paul K, ZURENKO, Gary E, SWEENEY, Michael T, YAGI, Betty H

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Streptomyces cloning: possible construction of novel compounds and regulation of antibiotic biosynthetic genes von TOMICH, P. K

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The Ligand Affinity of Proteins Measured by Isothermal Denaturation Kinetics von Epps, Dennis E., Sarver, Ronald W., Rogers, Joseph M., Herberg, John T., Tomich, Paul K.

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Plasmid-Related Transmissibility and Multiple Drug Resistance in Streptococcus faecalis subsp. zymogenes Strain DS16 von Tomich, P K, An, F Y, Damle, S P, Clewell, D B

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A high-throughput resonance energy transfer assay for Staphylococcus aureus DNA ligase von Benson, Ericka L, Tomich, Paul K, Wolfe, Mark L, Choi, Gil H, Hagadorn, Jeanne C, Mutchler, Veronica T, Garlick, Robert L

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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition von Thorarensen, Atli, Douglas, Jr, Martin R., Rohrer, Douglas C., Vosters, Anne F., Yem, Anthony W., Marshall, Vincent D., Lynn, Janet C., Bohanon, Michael J., Tomich, Paul K., Zurenko, Gary E., Sweeney, Michael T., Jensen, Randy M., Nielsen, James W., Seest, Eric P., Dolak, Lester A.

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Non-peptidic HIV protease inhibitors : C2-SYMMETRY-BASED design of bis-sulfonamide dihydropyrones von JANAKIRAMAN, M. N, WATENPAUGH, K. D, TOMICH, P. K, CHONG, K.-T, TURNER, S. R, TOMMASI, R. A, THAISRIVONGS, S, STROHBACH, J. W

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Development of activity assays for high-volume evaluation of human immunodeficiency virus (HIV) protease inhibitors in rat serum : results with ditekiren von WILKINSON, K. F, RUSH, B. D, SHARMA, S. K, EVANS, D. B, RUWART, M. J, FRIIS, J. M, BOHANON, M. J, TOMICH, P. K

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Tipranavir (PNU-140690):  A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class von Turner, Steve R, Strohbach, Joseph W, Tommasi, Ruben A, Aristoff, Paul A, Johnson, Paul D, Skulnick, Harvey I, Dolak, Lester A, Seest, Eric P, Tomich, Paul K, Bohanon, Michael J, Horng, Miao-Miao, Lynn, Janet C, Chong, Kong-Teck, Hinshaw, Roger R, Watenpaugh, Keith D, Janakiraman, Musiri N, Thaisrivongs, Suvit

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Simultaneous Initiation of Synthesis of Bacteriophage T4 DNA and of Deoxyribonucleotides von Chiu, Che-Shen, Tomich, Paul K., Greenberg, G. Robert

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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors von Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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