Repression of viral gene expression and replication by the unfolded protein response effector XBP1u von Hinte, Florian, van Anken, Eelco, Tirosh, Boaz, Brune, Wolfram

Volltext

Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know von Aronov, Michael, Tirosh, Boaz

Volltext

Direct activation of mTOR in B lymphocytes confers impairment in B‐cell maturation andloss of marginal zone B cells von Benhamron, Sandrine, Tirosh, Boaz

Volltext

A slowly cleaved viral signal peptide acts as a protein-integral immune evasion domain von Seidel, Einat, Dassa, Liat, Kahlon, Shira, Tirosh, Boaz, Halenius, Anne, Seidel Malkinson, Tal, Mandelboim, Ofer

Volltext

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress―Induced Diabetes von BACHAR-WIKSTROM, Etty, WIKSTROM, Jakob D, ARIAV, Yafa, TIROSH, Boaz, KAISER, Nurit, CERASI, Erol, LEIBOWITZ, Gil

Volltext

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors von Mahameed, Mohamed, Wilhelm, Thomas, Darawshi, Odai, Obiedat, Akram, Tommy, Weiss-Sadan, Chintha, Chetan, Schubert, Thomas, Samali, Afshin, Chevet, Eric, Eriksson, Leif A., Huber, Michael, Tirosh, Boaz

Volltext

Proximal Tubule mTORC1 Is a Central Player in the Pathophysiology of Diabetic Nephropathy and Its Correction by SGLT2 Inhibitors von Kogot-Levin, Aviram, Hinden, Liad, Riahi, Yael, Israeli, Tal, Tirosh, Boaz, Cerasi, Erol, Mizrachi, Ernesto Bernal, Tam, Joseph, Mosenzon, Ofri, Leibowitz, Gil

Volltext

Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy von Mahameed, Mohamed, Boukeileh, Shatha, Obiedat, Akram, Darawshi, Odai, Dipta, Priya, Rimon, Amit, McLennan, Gordon, Fassler, Rosi, Reichmann, Dana, Karni, Rotem, Preisinger, Christian, Wilhelm, Thomas, Huber, Michael, Tirosh, Boaz

Volltext

mTOR Activation Promotes Plasma Cell Differentiation and Bypasses XBP-1 for Immunoglobulin Secretion von Benhamron, Sandrine, Pattanayak, Shakti P., Berger, Michael, Tirosh, Boaz

Volltext

CHOP is a critical regulator of acetaminophen-induced hepatotoxicity von Uzi, Dotan, Barda, Liran, Scaiewicz, Viviana, Mills, Maya, Mueller, Tobias, Gonzalez-Rodriguez, Agueda, Valverde, Angela M, Iwawaki, Takao, Nahmias, Yaacov, Xavier, Ramnik, Chung, Ray T, Tirosh, Boaz, Shibolet, Oren

Volltext

Towards Enhancing Therapeutic Glycoprotein Bioproduction: Interventions in the PI3K/AKT/mTOR Pathway von Mahameed, Mohamed, Sulieman, Afnan, Alkam, Duah, Tirosh, Boaz

Volltext

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity von Chen, Chien-Wen, Guan, Bo-Jhih, Alzahrani, Mohammed R., Gao, Zhaofeng, Gao, Long, Bracey, Syrena, Wu, Jing, Mbow, Cheikh A., Jobava, Raul, Haataja, Leena, Zalavadia, Ajay H., Schaffer, Ashleigh E., Lee, Hugo, LaFramboise, Thomas, Bederman, Ilya, Arvan, Peter, Mathews, Clayton E., Gerling, Ivan C., Kaestner, Klaus H., Tirosh, Boaz, Engin, Feyza, Hatzoglou, Maria

Volltext

Regulated IRE1‐dependent decay participates in curtailing immunoglobulin secretion from plasma cells von Benhamron, Sandrine, Hadar, Rivka, Iwawaky, Takao, So, Jae‐Seon, Lee, Ann‐Hwee, Tirosh, Boaz

Volltext

The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice von Grajales, Diana, Vázquez, Patricia, Ruíz-Rosario, Mónica, Tudurí, Eva, Mirasierra, Mercedes, Ferreira, Vítor, Hitos, Ana B., Koller, Dora, Zubiaur, Pablo, Cigudosa, Juan C., Abad-Santos, Francisco, Vallejo, Mario, Quesada, Iván, Tirosh, Boaz, Leibowitz, Gil, Valverde, Ángela M.

Volltext

The integrated stress response promotes B7H6 expression von Obiedat, Akram, Charpak-Amikam, Yoav, Tai-Schmiedel, Julie, Seidel, Einat, Mahameed, Mohamed, Avril, Tony, Stern-Ginossar, Noam, Springuel, Lorraine, Bolsée, Jennifer, Gilham, David E., Dipta, Priya, Shmuel, Miriam, Chevet, Eric, Mandelboim, Ofer, Tirosh, Boaz

Volltext

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response von Merquiol, Emmanuelle, Uzi, Dotan, Mueller, Tobias, Goldenberg, Daniel, Nahmias, Yaakov, Xavier, Ramnik J, Tirosh, Boaz, Shibolet, Oren

Volltext

Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling von Goldfinger, Meidan, Shmuel, Miri, Benhamron, Sandrine, Tirosh, Boaz

Volltext

Endoplasmic Reticulum Homeostasis Regulates TLR4 Expression and Signaling in Mast Cells von Boukeileh, Shatha, Darawshi, Odai, Shmuel, Miriam, Mahameed, Mohamed, Wilhelm, Thomas, Dipta, Priya, Forno, Francesca, Praveen, Bellam, Huber, Michael, Levi-Schaffer, Francesca, Tirosh, Boaz

Volltext

CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance von Drori, Adi, Gammal, Asaad, Azar, Shahar, Hinden, Liad, Hadar, Rivka, Wesley, Daniel, Nemirovski, Alina, Szanda, Gergo, Salton, Maayan, Tirosh, Boaz, Tam, Joseph

Volltext

Hepatic Amiodarone Lipotoxicity Is Ameliorated by Genetic and Pharmacological Inhibition of Endoplasmatic Reticulum Stress von Erez, Noam, Hubel, Einav, Avraham, Roy, Cohen, Raya, Fishman, Sigal, Bantel, Heike, Manns, Michael, Tirosh, Boaz, Zvibel, Isabel, Shibolet, Oren

Volltext