Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma von Msaouel, Pavlos, Malouf, Gabriel G., Su, Xiaoping, Yao, Hui, Tripathi, Durga N., Soeung, Melinda, Gao, Jianjun, Rao, Priya, Coarfa, Cristian, Creighton, Chad J., Bertocchio, Jean-Philippe, Kunnimalaiyaan, Selvi, Multani, Asha S., Blando, Jorge, He, Rong, Shapiro, Daniel D., Perelli, Luigi, Srinivasan, Sanjana, Carbone, Federica, Pilié, Patrick G., Karki, Menuka, Seervai, Riyad N.H., Vokshi, Bujamin H., Lopez-Terrada, Dolores, Cheng, Emily H., Tang, Ximing, Lu, Wei, Wistuba, Ignacio I., Thompson, Timothy C., Davidson, Irwin, Giuliani, Virginia, Schlacher, Katharina, Carugo, Alessandro, Heffernan, Timothy P., Sharma, Padmanee, Karam, Jose A., Wood, Christopher G., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M.

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PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy von Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P., Gera, Sonal, Kovacs, Jeffrey J., Marszalek, Joseph R., Bristow, Christopher, Yan, Yuanqing, Garcia-Manero, Guillermo, Kantarjian, Hagop, Vassiliou, George, Futreal, P. Andrew, Donehower, Lawrence A., Takahashi, Koichi, Goodell, Margaret A.

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Crisis and Belonging: Protest Voices and Empathic Solidarity in Post-Economic Collapse Iceland von Heffernan, Timothy

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Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis von Del Poggetto, Edoardo, Ho, I-Lin, Balestrieri, Chiara, Yen, Er-Yen, Zhang, Shaojun, Citron, Francesca, Shah, Rutvi, Corti, Denise, Diaferia, Giuseppe R, Li, Chieh-Yuan, Loponte, Sara, Carbone, Federica, Hayakawa, Yoku, Valenti, Giovanni, Jiang, Shan, Sapio, Luigi, Jiang, Hong, Dey, Prasenjit, Gao, Sisi, Deem, Angela K, Rose-John, Stefan, Yao, Wantong, Ying, Haoqiang, Rhim, Andrew D, Genovese, Giannicola, Heffernan, Timothy P, Maitra, Anirban, Wang, Timothy C, Wang, Linghua, Draetta, Giulio F, Carugo, Alessandro, Natoli, Gioacchino, Viale, Andrea

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc von Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

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Telomere dysfunction induces metabolic and mitochondrial compromise von Sahin, Ergün, Colla, Simona, Liesa, Marc, Moslehi, Javid, Müller, Florian L., Guo, Mira, Cooper, Marcus, Kotton, Darrell, Fabian, Attila J., Walkey, Carl, Maser, Richard S., Tonon, Giovanni, Foerster, Friedrich, Xiong, Robert, Wang, Y. Alan, Shukla, Sachet A., Jaskelioff, Mariela, Martin, Eric S., Heffernan, Timothy P., Protopopov, Alexei, Ivanova, Elena, Mahoney, John E., Kost-Alimova, Maria, Perry, Samuel R., Bronson, Roderick, Liao, Ronglih, Mulligan, Richard, Shirihai, Orian S., Chin, Lynda, DePinho, Ronald A.

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Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis von Kim, Michael P, Li, Xinqun, Deng, Jenying, Zhang, Yun, Dai, Bingbing, Allton, Kendra L, Hughes, Tara G, Siangco, Christian, Augustine, Jithesh J, Kang, Ya'an, McDaniel, Joy M, Xiong, Shunbin, Koay, Eugene J, McAllister, Florencia, Bristow, Christopher A, Heffernan, Timothy P, Maitra, Anirban, Liu, Bin, Barton, Michelle C, Wasylishen, Amanda R, Fleming, Jason B, Lozano, Guillermina

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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer von Echeverria, Gloria V., Powell, Emily, Seth, Sahil, Ge, Zhongqi, Carugo, Alessandro, Bristow, Christopher, Peoples, Michael, Robinson, Frederick, Qiu, Huan, Shao, Jiansu, Jeter-Jones, Sabrina L., Zhang, Xiaomei, Ramamoorthy, Vandhana, Cai, Shirong, Wu, Wenhui, Draetta, Giulio, Moulder, Stacy L., Symmans, William F., Chang, Jeffrey T., Heffernan, Timothy P., Piwnica-Worms, Helen

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Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials von Yap, Timothy A., Daver, Naval, Mahendra, Mikhila, Zhang, Jixiang, Kamiya-Matsuoka, Carlos, Meric-Bernstam, Funda, Kantarjian, Hagop M., Ravandi, Farhad, Collins, Meghan E., Francesco, Maria Emilia Di, Dumbrava, Ecaterina E., Fu, Siqing, Gao, Sisi, Gay, Jason P., Gera, Sonal, Han, Jing, Hong, David S., Jabbour, Elias J., Ju, Zhenlin, Karp, Daniel D., Lodi, Alessia, Molina, Jennifer R., Baran, Natalia, Naing, Aung, Ohanian, Maro, Pant, Shubham, Pemmaraju, Naveen, Bose, Prithviraj, Piha-Paul, Sarina A., Rodon, Jordi, Salguero, Carolina, Sasaki, Koji, Singh, Anand K., Subbiah, Vivek, Tsimberidou, Apostolia M., Xu, Quanyun A., Yilmaz, Musa, Zhang, Qi, Li, Yuan, Bristow, Christopher A., Bhattacharjee, Meenakshi B., Tiziani, Stefano, Heffernan, Timothy P., Vellano, Christopher P., Jones, Philip, Heijnen, Cobi J., Kavelaars, Annemieke, Marszalek, Joseph R., Konopleva, Marina

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition von Hofmann, Marco H, Gmachl, Michael, Ramharter, Juergen, Savarese, Fabio, Gerlach, Daniel, Marszalek, Joseph R, Sanderson, Michael P, Kessler, Dirk, Trapani, Francesca, Arnhof, Heribert, Rumpel, Klaus, Botesteanu, Dana-Adriana, Ettmayer, Peter, Gerstberger, Thomas, Kofink, Christiane, Wunberg, Tobias, Zoephel, Andreas, Fu, Szu-Chin, Teh, Jessica L, Böttcher, Jark, Pototschnig, Nikolai, Schachinger, Franziska, Schipany, Katharina, Lieb, Simone, Vellano, Christopher P, O'Connell, Jonathan C, Mendes, Rachel L, Moll, Jurgen, Petronczki, Mark, Heffernan, Timothy P, Pearson, Mark, McConnell, Darryl B, Kraut, Norbert

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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies von Vangamudi, Bhavatarini, Paul, Thomas A, Shah, Parantu K, Kost-Alimova, Maria, Nottebaum, Lisa, Shi, Xi, Zhan, Yanai, Leo, Elisabetta, Mahadeshwar, Harshad S, Protopopov, Alexei, Futreal, Andrew, Tieu, Trang N, Peoples, Mike, Heffernan, Timothy P, Marszalek, Joseph R, Toniatti, Carlo, Petrocchi, Alessia, Verhelle, Dominique, Owen, Dafydd R, Draetta, Giulio, Jones, Philip, Palmer, Wylie S, Sharma, Shikhar, Andersen, Jannik N

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Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer von Evans, Kurt W, Yuca, Erkan, Scott, Stephen S, Zhao, Ming, Paez Arango, Natalia, Cruz Pico, Christian X, Saridogan, Turcin, Shariati, Maryam, Class, Caleb A, Bristow, Christopher A, Vellano, Christopher P, Zheng, Xiaofeng, Gonzalez-Angulo, Ana Maria, Su, Xiaoping, Tapia, Coya, Chen, Ken, Akcakanat, Argun, Lim, Bora, Tripathy, Debu, Yap, Timothy A, Francesco, Maria Emilia Di, Draetta, Giulio F, Jones, Philip, Heffernan, Timothy P, Marszalek, Joseph R, Meric-Bernstam, Funda

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function von Viale, Andrea, Pettazzoni, Piergiorgio, Lyssiotis, Costas A., Ying, Haoqiang, Sánchez, Nora, Marchesini, Matteo, Carugo, Alessandro, Green, Tessa, Seth, Sahil, Giuliani, Virginia, Kost-Alimova, Maria, Muller, Florian, Colla, Simona, Nezi, Luigi, Genovese, Giannicola, Deem, Angela K., Kapoor, Avnish, Yao, Wantong, Brunetto, Emanuela, Kang, Ya’an, Yuan, Min, Asara, John M., Wang, Y. Alan, Heffernan, Timothy P., Kimmelman, Alec C., Wang, Huamin, Fleming, Jason B., Cantley, Lewis C., DePinho, Ronald A., Draetta, Giulio F.

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Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy von Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

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Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition von Yan, Liang, Tu, Bo, Yao, Jun, Gong, Jing, Carugo, Alessandro, Bristow, Christopher A, Wang, Qiuyun, Zhu, Cihui, Dai, Bingbing, Kang, Ya'an, Han, Leng, Feng, Ningping, Jin, Yanqing, Fleming, Jason, Heffernan, Timothy P, Yao, Wantong, Ying, Haoqiang

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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells von Mahadevan, Krishnan K., McAndrews, Kathleen M., LeBleu, Valerie S., Yang, Sujuan, Lyu, Hengyu, Li, Bingrui, Sockwell, Amari M., Kirtley, Michelle L., Morse, Sami J., Moreno Diaz, Barbara A., Kim, Michael P., Feng, Ningping, Lopez, Anastasia M., Guerrero, Paola A., Paradiso, Francesca, Sugimoto, Hikaru, Arian, Kent A., Ying, Haoqiang, Barekatain, Yasaman, Sthanam, Lakshmi Kavitha, Kelly, Patience J., Maitra, Anirban, Heffernan, Timothy P., Kalluri, Raghu

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Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy von Peng, Weiyi, Chen, Jie Qing, Liu, Chengwen, Malu, Shruti, Creasy, Caitlin, Tetzlaff, Michael T, Xu, Chunyu, McKenzie, Jodi A, Zhang, Chunlei, Liang, Xiaoxuan, Williams, Leila J, Deng, Wanleng, Chen, Guo, Mbofung, Rina, Lazar, Alexander J, Torres-Cabala, Carlos A, Cooper, Zachary A, Chen, Pei-Ling, Tieu, Trang N, Spranger, Stefani, Yu, Xiaoxing, Bernatchez, Chantale, Forget, Marie-Andree, Haymaker, Cara, Amaria, Rodabe, McQuade, Jennifer L, Glitza, Isabella C, Cascone, Tina, Li, Haiyan S, Kwong, Lawrence N, Heffernan, Timothy P, Hu, Jianhua, Bassett, Jr, Roland L, Bosenberg, Marcus W, Woodman, Scott E, Overwijk, Willem W, Lizée, Gregory, Roszik, Jason, Gajewski, Thomas F, Wargo, Jennifer A, Gershenwald, Jeffrey E, Radvanyi, Laszlo, Davies, Michael A, Hwu, Patrick

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Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities von Skoulidis, Ferdinandos, Byers, Lauren A, Diao, Lixia, Papadimitrakopoulou, Vassiliki A, Tong, Pan, Izzo, Julie, Behrens, Carmen, Kadara, Humam, Parra, Edwin R, Canales, Jaime Rodriguez, Zhang, Jianjun, Giri, Uma, Gudikote, Jayanthi, Cortez, Maria A, Yang, Chao, Fan, Youhong, Peyton, Michael, Girard, Luc, Coombes, Kevin R, Toniatti, Carlo, Heffernan, Timothy P, Choi, Murim, Frampton, Garrett M, Miller, Vincent, Weinstein, John N, Herbst, Roy S, Wong, Kwok-Kin, Zhang, Jianhua, Sharma, Padmanee, Mills, Gordon B, Hong, Waun K, Minna, John D, Allison, James P, Futreal, Andrew, Wang, Jing, Wistuba, Ignacio I, Heymach, John V

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors von Carugo, Alessandro, Minelli, Rosalba, Sapio, Luigi, Soeung, Melinda, Carbone, Federica, Robinson, Frederick S., Tepper, James, Chen, Ziheng, Lovisa, Sara, Svelto, Maria, Amin, Samirkumar, Srinivasan, Sanjana, Del Poggetto, Edoardo, Loponte, Sara, Puca, Francesca, Dey, Prasenjit, Malouf, Gabriel G., Su, Xiaoping, Li, Liren, Lopez-Terrada, Dolores, Rakheja, Dinesh, Lazar, Alexander J., Netto, George J., Rao, Priya, Sgambato, Alessandro, Maitra, Anirban, Tripathi, Durga N., Walker, Cheryl L., Karam, Jose A., Heffernan, Timothy P., Viale, Andrea, Roberts, Charles W.M., Msaouel, Pavlos, Tannir, Nizar M., Draetta, Giulio F., Genovese, Giannicola

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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer von Genovese, Giannicola, Carugo, Alessandro, Tepper, James, Robinson, Frederick Scott, Li, Liren, Svelto, Maria, Nezi, Luigi, Corti, Denise, Minelli, Rosalba, Pettazzoni, Piergiorgio, Gutschner, Tony, Wu, Chia-Chin, Seth, Sahil, Akdemir, Kadir Caner, Leo, Elisabetta, Amin, Samirkumar, Molin, Marco Dal, Ying, Haoqiang, Kwong, Lawrence N., Colla, Simona, Takahashi, Koichi, Ghosh, Papia, Giuliani, Virginia, Muller, Florian, Dey, Prasenjit, Jiang, Shan, Garvey, Jill, Liu, Chang-Gong, Zhang, Jianhua, Heffernan, Timothy P., Toniatti, Carlo, Fleming, Jason B., Goggins, Michael G., Wood, Laura D., Sgambato, Alessandro, Agaimy, Abbas, Maitra, Anirban, Roberts, Charles W. M., Wang, Huamin, Viale, Andrea, DePinho, Ronald A., Draetta, Giulio F., Chin, Lynda

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