The importance of synthetic chemistry in the pharmaceutical industry von Campos, Kevin R, Coleman, Paul J, Alvarez, Juan C, Dreher, Spencer D, Garbaccio, Robert M, Terrett, Nicholas K, Tillyer, Richard D, Truppo, Matthew D, Parmee, Emma R

Volltext

Correction to “A General Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones” von Campos, Kevin R, Woo, Jacqueline C. S, Lee, Sandra, Tillyer, Richard D

Volltext

Synthesis of Substituted Imidazoles via Organocatalysis von Frantz, Doug E, Morency, Louis, Soheili, Arash, Murry, Jerry A, Grabowski, Edward J. J, Tillyer, Richard D

Volltext

Highly Regioselective Synthesis of 1-Aryl-3,4,5-Substituted Pyrazoles von Gosselin, Francis, O’Shea, Paul D., Webster, Robert A., Reamer, Robert A., Tillyer, Richard D., Grabowski, Edward J.

Volltext

Highly Efficient Synthesis of β-Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines von Hsiao, Yi, Rivera, Nelo R, Rosner, Thorsten, Krska, Shane W, Njolito, Eugenia, Wang, Fang, Sun, Yongkui, Armstrong, Joseph D, Grabowski, Edward J. J, Tillyer, Richard D, Spindler, Felix, Malan, Christophe

Volltext

A General Synthesis of Substituted Indoles from Cyclic Enol Ethers and Enol Lactones von Campos, Kevin R, Woo, Jacqueline C. S, Lee, Sandra, Tillyer, Richard D

Volltext

A Novel, Highly Enantioselective Ketone Alkynylation Reaction Mediated by Chiral Zinc Aminoalkoxides von Tan, Lushi, Chen, Cheng-yi, Tillyer, Richard D., Grabowski, Edward J. J., Reider, Paul J.

Volltext

Stereoselective Formation of Carbon−Carbon Bonds via SN2-Displacement:  Synthesis of Substituted Cycloalkyl[b]indoles von Hillier, Michael C, Marcoux, Jean-François, Zhao, Dalian, Grabowski, Edward J. J, McKeown, Arlene E, Tillyer, Richard D

Volltext

Nucleophilic Displacement at Benzhydryl Centers:  Asymmetric Synthesis of 1,1-Diarylalkyl Derivatives von Bolshan, Yuri, Chen, Cheng-yi, Chilenski, Jennifer R, Gosselin, Francis, Mathre, David J, O'Shea, Paul D, Roy, Amélie, Tillyer, Richard D

Volltext

Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor von Pierce, Michael E, Parsons, Rodney L, Radesca, Lilian A, Lo, Young S, Silverman, Stuart, Moore, James R, Islam, Qamrul, Choudhury, Anusuya, Fortunak, Joseph M. D, Nguyen, Dieu, Luo, Chi, Morgan, Susan J, Davis, Wayne P, Confalone, Pat N, Chen, Cheng-yi, Tillyer, Richard D, Frey, Lisa, Tan, Lushi, Xu, Feng, Zhao, Dalian, Thompson, Andrew S, Corley, Edward G, Grabowski, Edward J. J, Reamer, Robert, Reider, Paul J

Volltext

Practical Asymmetric Synthesis of a Potent PDE4 Inhibitor via Stereoselective Enolate Alkylation of a Chiral Aryl−Heteroaryl Secondary Tosylate von O'Shea, Paul D, Chen, Cheng-yi, Chen, Weirong, Dagneau, Philippe, Frey, Lisa F, Grabowski, Edward J. J, Marcantonio, Karen M, Reamer, Robert A, Tan, Lushi, Tillyer, Richard D, Roy, Amélie, Wang, Xin, Zhao, Dalian

Volltext

Asymmetric Synthesis of a Prostaglandin D2 Receptor Antagonist von Campos, Kevin R, Journet, Michel, Lee, Sandra, Grabowski, Edward J. J, Tillyer, Richard D

Volltext

On the Mechanism of an Asymmetric α,β-Unsaturated Carboxylic Acid Hydrogenation:  Application to the Synthesis of a PGD2 Receptor Antagonist von Tellers, David M, McWilliams, J. Christopher, Humphrey, Guy, Journet, Michel, DiMichele, Lisa, Hinksmon, Joseph, McKeown, Arlene E, Rosner, Thorsten, Sun, Yongkui, Tillyer, Richard D

Volltext

Highly Enantioselective 1,2-Addition of Lithium Acetylide-Ephedrate Complexes:  Spectroscopic Evidence for Reaction Proceeding via a 2:2 Tetramer, and X-ray Characterization of Rel... von Xu, Feng, Reamer, Robert A, Tillyer, Richard, Cummins, Jordan M, Grabowski, Edward J. J, Reider, Paul J, Collum, David B, Huffman, John C

Volltext

Highly Diastereoselective Heterogeneously Catalyzed Hydrogenation of Enamines for the Synthesis of Chiral β-Amino Acid Derivatives von Ikemoto, Norihiro, Tellers, David M, Dreher, Spencer D, Liu, Jinchu, Huang, Angie, Rivera, Nelo R, Njolito, Eugenia, Hsiao, Yi, McWilliams, J. Christopher, Williams, J. Michael, Armstrong, Joseph D, Sun, Yongkui, Mathre, David J, Grabowski, Edward J. J, Tillyer, Richard D

Volltext

Stereoselective Syntheses of Highly Functionalized Bicyclo[3.1.0]hexanes:  A General Methodology for the Synthesis of Potent and Selective mGluR2/3 Agonists von Tan, Lushi, Yasuda, Nobuyoshi, Yoshikawa, Naoki, Hartner, Frederick W, Eng, Kan Kaung, Leonard, William R, Tsay, Fuh-Rong, Volante, Ralph P, Tillyer, Richard D

Volltext

Practical Asymmetric Synthesis of an Endothelin Receptor Antagonist von Song, Zhiguo J, Zhao, Mangzhu, Desmond, Richard, Devine, Paul, Tschaen, David M, Tillyer, Richard, Frey, Lisa, Heid, Richard, Xu, Feng, Foster, Bruce, Li, Jing, Reamer, Robert, Volante, Ralph, Dolling, Ulf H, Reider, Paul J, Okada, Shigemitsu, Kato, Yoshiaki, Mano, Eiichi

Volltext

An Efficient Asymmetric Synthesis of an Estrogen Receptor Modulator by Sulfoxide-Directed Borane Reduction von Song, Zhiguo J., King, Anthony O., Waters, Marjorie S., Lang, Fengrui, Zewge, Daniel, Bio, Matthew, Leazer, Johnnie L., Javadi, Gary, Kassim, Amude, Tschaen, David M., Reamer, Robert A., Rosner, Thorsten, Chilenski, Jennifer R., Mathre, David J., Volante, R. P., Tillyer, Richard, Trost, Barry M.

Volltext

Practical Asymmetric Synthesis of a Selective Endothelin A Receptor (ETA) Antagonist von Song, Zhiguo J, Zhao, Matthew, Frey, Lisa, Li, Jing, Tan, Lushi, Chen, Cheng Y, Tschaen, David M, Tillyer, Richard, Grabowski, Edward J. J, Volante, Ralph, Reider, Paul J, Kato, Yoshiaki, Okada, Shigemitsu, Nemoto, Takayuki, Sato, Hiroki, Akao, Atsushi, Mase, Toshiaki

Volltext

Practical enantioselective synthesis of a COX-2 specific inhibitor von Tan, Lushi, Chen, Cheng-yi, Chen, Weirong, Frey, Lisa, King, Anthony O, Tillyer, Richard D, Xu, Feng, Zhao, Dalian, Grabowski, Edward J.J, Reider, Paul J, O'Shea, Paul, Dagneau, Philippe, Wang, Xin

Volltext