Antibody-Drug Conjugates: Future Directions in Clinical and Translational Strategies to Improve the Therapeutic Index von Coats, Steven, Williams, Marna, Kebble, Benjamin, Dixit, Rakesh, Tseng, Leo, Yao, Nai-Shun, Tice, David A, Soria, Jean-Charles

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MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgro... von Greer, Yoshimi Endo, Gilbert, Samuel F, Gril, Brunilde, Narwal, Rajesh, Peacock Brooks, Danielle L, Tice, David A, Steeg, Patricia S, Lipkowitz, Stanley

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SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads von Kinneer, Krista, Meekin, John, Tiberghien, Arnaud C, Tai, Yu-Tzu, Phipps, Sandrina, Kiefer, Christine Mione, Rebelatto, Marlon C, Dimasi, Nazzareno, Moriarty, Alyssa, Papadopoulos, Kyriakos P, Sridhar, Sriram, Gregson, Stephen J, Wick, Michael J, Masterson, Luke, Anderson, Kenneth C, Herbst, Ronald, Howard, Philip W, Tice, David A

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A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors von Zhong, Haihong, Davis, April, Ouzounova, Maria, Carrasco, Rosa A, Chen, Cui, Breen, Shannon, Chang, Yong S, Huang, Jiaqi, Liu, Zheng, Yao, Yihong, Hurt, Elaine, Moisan, Jacques, Fung, Michael, Tice, David A, Clouthier, Shawn G, Xiao, Zhan, Wicha, Max S, Korkaya, Hasan, Hollingsworth, Robert E

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Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 von Kinneer, Krista, Wortmann, Philipp, Cooper, Zachary A, Dickinson, Niall J, Masterson, Luke, Cailleau, Thais, Hutchinson, Ian, Vijayakrishnan, Balakumar, McFarlane, Mary, Ball, Kathryn, Davies, Michael, Lewis, Arthur, Huang, Yue, Rosenbaum, Anton I, Yuan, Jiaqi, Chesebrough, Jon, Anderton, Judith, Monks, Noel, Novick, Steven, Wang, Jixin, Dimasi, Nazzareno, Christie, R James, Sabol, Darrin, Tosto, Frances Anne, Wallez, Yann, Leo, Elisabetta, Albertella, Mark R, Staniszewska, Anna D, Tice, David A, Howard, Philip W, Luheshi, Nadia, Sapra, Puja

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Controlling CAR-T cell activity and specificity with synthetic SparX adapters von Edwards, Justin P., Swers, Jeffrey S., Buonato, Janine M., Zaritskaya, Liubov, Mu, C. Jenny, Gupta, Ankit, Shachar, Sigal, LaFleur, David W., Richman, Laura K., Tice, David A., Hilbert, David M.

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Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer von Jiang, Liyan, Huang, Jiaqi, Higgs, Brandon W, Hu, Zhibin, Xiao, Zhan, Yao, Xin, Conley, Sarah, Zhong, Haihong, Liu, Zheng, Brohawn, Philip, Shen, Dong, Wu, Song, Ge, Xiaoxiao, Jiang, Yue, Zhao, Yizhuo, Lou, Yuqing, Morehouse, Chris, Zhu, Wei, Sebastian, Yinong, Czapiga, Meggan, Oganesyan, Vaheh, Fu, Haihua, Niu, Yanjie, Zhang, Wei, Streicher, Katie, Tice, David, Zhao, Heng, Zhu, Meng, Xu, Lin, Herbst, Ronald, Su, Xinying, Gu, Yi, Li, Shyoung, Huang, Lihua, Gu, Jianren, Han, Baohui, Jallal, Bahija, Shen, Hongbing, Yao, Yihong

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Preclinical assessment of an antibody–PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells von Kinneer, Krista, Flynn, Matt, Thomas, Suneetha B., Meekin, John, Varkey, Reena, Xiao, Xiaodong, Zhong, Haihong, Breen, Shannon, Hynes, Paul G., Fleming, Ryan, Bezabeh, Binyam, Chen, Cui (Tracy), Wetzel, Leslie, Chen, Ruoyan, Dimasi, Nazzareno, Tai, Yu-Tzu, Anderson, Kenneth C., Herbst, Ronald, Howard, Philip W., Hurt, Elaine M., Tice, David A.

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Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain von Buonato, Janine M, Edwards, Justin P, Zaritskaya, Liubov, Witter, Alexandra R, Gupta, Ankit, LaFleur, David W, Tice, David A, Richman, Laura K, Hilbert, David M

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Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR von Mao, Shenlan, Chaerkady, Raghothama, Yu, Wen, D'Angelo, Gina, Garcia, Andrew, Chen, Hong, Barrett, Allison M, Phipps, Sandrina, Fleming, Ryan, Hess, Sonja, Koopmann, Jens-Oliver, Dimasi, Nazzareno, Wilson, Susan, Pugh, Kathryn, Cook, Kimberly, Masterson, Luke A, Gao, Changshou, Wu, Herren, Herbst, Ronald, Howard, Philip W, Tice, David A, Cobbold, Mark, Harper, Jay

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Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression von Sungalee, Stéphanie, Mamessier, Emilie, Morgado, Ester, Grégoire, Emilie, Brohawn, Philip Z, Morehouse, Christopher A, Jouve, Nathalie, Monvoisin, Céline, Menard, Cédric, Debroas, Guilhaume, Faroudi, Mustapha, Mechin, Violaine, Navarro, Jean-Marc, Drevet, Charlotte, Eberle, Franziska C, Chasson, Lionel, Baudimont, Fannie, Mancini, Stéphane J, Tellier, Julie, Picquenot, Jean-Michel, Kelly, Rachel, Vineis, Paolo, Ruminy, Philippe, Chetaille, Bruno, Jaffe, Elaine S, Schiff, Claudine, Hardwigsen, Jean, Tice, David A, Higgs, Brandon W, Tarte, Karin, Nadel, Bertrand, Roulland, Sandrine

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Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells von Yang, Nai-Ying, Fernandez, Carlos, Richter, Melanie, Xiao, Zhan, Valencia, Fatima, Tice, David A., Pasquale, Elena B.

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EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target von Xiao, Zhan, Carrasco, Rosa, Kinneer, Krista, Sabol, Darrin, Jallal, Bahija, Coats, Steve, Tice, David A.

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A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways von Rios-Doria, Jonathan, Sabol, Darrin, Chesebrough, Jon, Stewart, Dave, Xu, Linda, Tammali, Ravinder, Cheng, Li, Du, Qun, Schifferli, Kevin, Rothstein, Ray, Leow, Ching Ching, Heidbrink-Thompson, Jenny, Jin, Xiaofang, Gao, Changshou, Friedman, Jay, Wilkinson, Brandy, Damschroder, Melissa, Pierce, Andrew J, Hollingsworth, Robert E, Tice, David A, Michelotti, Emil F

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Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis von Swers, Jeffery S, Grinberg, Luba, Wang, Lin, Feng, Hui, Lekstrom, Kristen, Carrasco, Rosa, Xiao, Zhan, Inigo, Ivan, Leow, Ching Ching, Wu, Herren, Tice, David A, Baca, Manuel

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Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists von Grinkevitch, Vera, Wappett, Mark, Crawford, Nyree, Price, Stacey, Lees, Andrea, McCann, Christopher, McAllister, Katherine, Prehn, Jochen, Young, Jamie, Bateson, Jess, Gallagher, Lewis, Michaut, Magali, Iyer, Vivek, Chatzipli, Aikaterini, Barthorpe, Syd, Ciznadija, Daniel, Sloma, Ido, Wesa, Amy, Tice, David A, Wessels, Lodewyk, Garnett, Mathew, Longley, Daniel B, McDermott, Ultan, McDade, Simon S

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Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer von Cho, Song, Zammarchi, Francesca, Williams, David G, Havenith, Carin E G, Monks, Noel R, Tyrer, Peter, D'Hooge, Francois, Fleming, Ryan, Vashisht, Kapil, Dimasi, Nazzareno, Bertelli, Francois, Corbett, Simon, Adams, Lauren, Reinert, Halla W, Dissanayake, Sandamali, Britten, Charles E, King, Wanda, Dacosta, Karma, Tammali, Ravinder, Schifferli, Kevin, Strout, Patrick, Korade, 3rd, Martin, Masson Hinrichs, Mary Jane, Chivers, Simon, Corey, Eva, Liu, He, Kim, Sae, Bander, Neil H, Howard, Philip W, Hartley, John A, Coats, Steve, Tice, David A, Herbst, Ronald, van Berkel, Patrick H

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5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma von Kerk, Samuel A, Finkel, Kelsey A, Pearson, Alexander T, Warner, Kristy A, Zhang, Zhaocheng, Nör, Felipe, Wagner, Vivian P, Vargas, Pablo A, Wicha, Max S, Hurt, Elaine M, Hollingsworth, Robert E, Tice, David A, Nör, Jacques E

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Improved Therapeutic Window in BRCA -mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition von Zhong, Haihong, Chen, Cui, Tammali, Ravinder, Breen, Shannon, Zhang, Jing, Fazenbaker, Christine, Kennedy, Maureen, Conway, James, Higgs, Brandon W, Holoweckyj, Nicholas, Raja, Rajiv, Harper, Jay, Pierce, Andrew J, Herbst, Ronald, Tice, David A

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Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody-Drug Conjugate Targeting 5T4 von Harper, Jay, Lloyd, Christopher, Dimasi, Nazzareno, Toader, Dorin, Marwood, Rose, Lewis, Leeanne, Bannister, David, Jovanovic, Jelena, Fleming, Ryan, D'Hooge, Francois, Mao, Shenlan, Marrero, Allison M, Korade, 3rd, Martin, Strout, Patrick, Xu, Linda, Chen, Cui, Wetzel, Leslie, Breen, Shannon, van Vlerken-Ysla, Lilian, Jalla, Sanjoo, Rebelatto, Marlon, Zhong, Haihong, Hurt, Elaine M, Hinrichs, Mary Jane, Huang, Keven, Howard, Philip W, Tice, David A, Hollingsworth, Robert E, Herbst, Ronald, Kamal, Adeela

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