SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads von Kinneer, Krista, Meekin, John, Tiberghien, Arnaud C, Tai, Yu-Tzu, Phipps, Sandrina, Kiefer, Christine Mione, Rebelatto, Marlon C, Dimasi, Nazzareno, Moriarty, Alyssa, Papadopoulos, Kyriakos P, Sridhar, Sriram, Gregson, Stephen J, Wick, Michael J, Masterson, Luke, Anderson, Kenneth C, Herbst, Ronald, Howard, Philip W, Tice, David A

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ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies von Zammarchi, Francesca, Corbett, Simon, Adams, Lauren, Tyrer, Peter C., Kiakos, Konstantinos, Janghra, Narinder, Marafioti, Teresa, Britten, Charles E., Havenith, Carin E.G., Chivers, Simon, D'Hooge, Francois, Williams, David G., Tiberghien, Arnaud, Howard, Philip W., Hartley, John A., van Berkel, Patrick H.

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Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload von Tiberghien, Arnaud C, Levy, Jean-Noel, Masterson, Luke A, Patel, Neki V, Adams, Lauren R, Corbett, Simon, Williams, David G, Hartley, John A, Howard, Philip W

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A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology von Jeffrey, Scott C, Burke, Patrick J, Lyon, Robert P, Meyer, David W, Sussman, Django, Anderson, Martha, Hunter, Joshua H, Leiske, Chris I, Miyamoto, Jamie B, Nicholas, Nicole D, Okeley, Nicole M, Sanderson, Russell J, Stone, Ivan J, Zeng, Weiping, Gregson, Stephen J, Masterson, Luke, Tiberghien, Arnaud C, Howard, Philip W, Thurston, David E, Law, Che-Leung, Senter, Peter D

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Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine von Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.

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Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody–Drug Conjugates Using Click Cycloaddition Chemistry von VanBrunt, Michael P, Shanebeck, Kurt, Caldwell, Zachary, Johnson, Jeffrey, Thompson, Pamela, Martin, Thomas, Dong, Huifang, Li, Gary, Xu, Hengyu, D’Hooge, Francois, Masterson, Luke, Bariola, Pauline, Tiberghien, Arnaud, Ezeadi, Ebele, Williams, David G, Hartley, John A, Howard, Philip W, Grabstein, Kenneth H, Bowen, Michael A, Marelli, Marcello

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An Isomerization Approach to Tesirine and Pyrrolobenzodiazepines von Campbell, Andrew D, Tomasi, Simone, Tiberghien, Arnaud C, Parker, Jeremy S

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Comparison of pyrrolobenzodiazepine dimer bis-imine versus mono-imine: DNA interstrand cross-linking, cytotoxicity, and antibody-drug conjugate efficacy and toxicity von Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W

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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity von Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W

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ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies von Flynn, Michael J, Zammarchi, Francesca, Tyrer, Peter C, Akarca, Ayse U, Janghra, Narinder, Britten, Charles E, Havenith, Carin E G, Levy, Jean-Noel, Tiberghien, Arnaud, Masterson, Luke A, Barry, Conor, D'Hooge, Francois, Marafioti, Teresa, Parren, Paul W H I, Williams, David G, Howard, Philip W, van Berkel, Patrick H, Hartley, John A

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Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates von Hinrichs, Mary Jane Masson, Ryan, Pauline M, Zheng, Bo, Afif-Rider, Shameen, Yu, Xiang Qing, Gunsior, Michele, Zhong, Haihong, Harper, Jay, Bezabeh, Binyam, Vashisht, Kapil, Rebelatto, Marlon, Reed, Molly, Ryan, Patricia C, Breen, Shannon, Patel, Neki, Chen, Cui, Masterson, Luke, Tiberghien, Arnaud, Howard, Phillip W, Dimasi, Nazzareno, Dixit, Rakesh

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An Alternative Focus for Route Design for the Synthesis of Antibody–Drug Conjugate Payloads von Tiberghien, Arnaud C, Howard, Philip W, Goundry, William R. F, McCormick, Marc, Parker, Jeremy S

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Scale-up Synthesis of Tesirine von Tiberghien, Arnaud C, von Bulow, Christina, Barry, Conor, Ge, Huajun, Noti, Christian, Collet Leiris, Florence, McCormick, Marc, Howard, Philip W, Parker, Jeremy S

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Preclinical characterization of an antibody-drug conjugate targeting CS-1 and the identification of uncharacterized populations of CS-1-positive cells von Chen, Ruoyan, Rajan, Saravanan, Overstreet, Michael G, Hurt, Elaine M, Thomas, Suneetha B, Muniz-Medina, Vanessa, Ward, Christopher, Sadowska, Agnieszka, Fleming, Ryan, Karanth, Subramanya, Breen, Shannon, Zheng, Bo, Wu, Yuling, Iverson, William O, Novick, Steven, O'Day, Terrence, Shah, Dipesha P, Dimasi, Nazzareno, Tiberghien, Arnaud C, Osbourn, Jane, Walker, Jill

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Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin von Kemp, Gary C., Tiberghien, Arnaud C., Patel, Neki V., D'Hooge, Francois, Nilapwar, Sanjay M., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.

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Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation von Christie, R., Tiberghien, Arnaud, Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip, Gao, Changshou

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A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis von MacGregor, Paula, Gonzalez-Munoz, Andrea L, Jobe, Fatoumatta, Taylor, Martin C, Rust, Steven, Sandercock, Alan M, Macleod, Olivia J S, Van Bocxlaer, Katrien, Francisco, Amanda F, D'Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S, Howard, Philip, Higgins, Matthew K, Vaughan, Tristan J, Minter, Ralph, Carrington, Mark

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Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents von Antonow, Dyeison, Kaliszczak, Maciej, Kang, Gyoung-Dong, Coffils, Marissa, Tiberghien, Arnaud C, Cooper, Nectaroula, Barata, Teresa, Heidelberger, Sibylle, James, Colin H, Zloh, Mire, Jenkins, Terence C, Reszka, Anthony P, Neidle, Stephen, Guichard, Sylvie M, Jodrell, Duncan I, Hartley, John A, Howard, Philip W, Thurston, David E

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SG2285, a Novel C2-Aryl-Substituted Pyrrolobenzodiazepine Dimer Prodrug That Cross-links DNA and Exerts Highly Potent Antitumor Activity von HARTLEY, John A, HAMAGUCHI, Anzu, PEPPER, Christopher, THET THET LIN, FEGAN, Christopher, THURSTON, David E, HOWARD, Philip W, COFFILS, Marissa, MARTIN, Christopher R. H, SUGGITT, Marie, ZHIZHI CHEN, GREGSON, Stephen J, MASTERSON, Luke A, TIBERGHIEN, Arnaud C, HARTLEY, Janet M

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Synthesis of a novel C2/C2′-aryl-substituted pyrrolo[2,1- c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate von Howard, Philip W., Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Cooper, Nectaroula, Fang, Min, Coffils, Marissa J., Klee, Sarah, Hartley, John A., Thurston, David E.

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